ID   H0ZSW6_TAEGU            Unreviewed;       159 AA.
AC   H0ZSW6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   03-OCT-2012, entry version 7.
DE   RecName: Full=Peptide methionine sulfoxide reductase MsrA;
DE            Short=Protein-methionine-S-oxide reductase;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
GN   Name=MSRA; Synonyms=msrA;
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Passeriformes; Passeroidea; Estrildidae; Estrildinae;
OC   Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2]
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data.
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DR   Ensembl; ENSTGUT00000013870; ENSTGUP00000013712; ENSTGUG00000013321.
DR   GeneTree; ENSGT00390000003823; -.
DR   OMA; TEISEAK; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:Compara.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase activity; IEA:Compara.
DR   GO; GO:0019538; P:protein metabolic process; IEA:InterPro.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   HAMAP; MF_01401; MsrA; 1; -.
DR   InterPro; IPR002569; Peptide_Met_Sox_Rdtase_MsrA.
DR   Pfam; PF01625; PMSR; 1.
DR   SUPFAM; SSF55068; MsrA; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase; Reference proteome.
FT   ACT_SITE     52     52       By similarity.
SQ   SEQUENCE   159 AA;  18018 MW;  EF57AE5D988EE290 CRC64;
     MGDQASRLPQ AGEALPGRTQ RMAVPDKHHV NGNRMVEPFP EGTQMALFGM GCFWGAERKF
     WRQKGVYSTQ VGYAGGHTPN PTYKEVCSGR TGHTEAVRVV FEPQNISFEQ LLKVFWENHD
     PTQGMRQGND VGTQYRSAIY TFSQEQMEAA LRSKEEYQK
//