ID H0ZSW6_TAEGU Unreviewed; 235 AA. AC H0ZSW6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 17-JUN-2020, sequence version 2. DT 27-NOV-2024, entry version 67. DE RecName: Full=peptide-methionine (S)-S-oxide reductase {ECO:0000256|ARBA:ARBA00012502}; DE EC=1.8.4.11 {ECO:0000256|ARBA:ARBA00012502}; DE AltName: Full=Peptide-methionine (S)-S-oxide reductase {ECO:0000256|ARBA:ARBA00030643}; DE AltName: Full=Protein-methionine-S-oxide reductase {ECO:0000256|ARBA:ARBA00030273}; GN Name=MSRA {ECO:0000313|Ensembl:ENSTGUP00000013712.2}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; OC Passeriformes; Passeroidea; Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000013712.2, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000013712.2, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E., RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P., RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O., RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L., RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C., RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K., RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A., RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000013712.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=[thioredoxin]-disulfide + L-methionine + H2O = L-methionine CC (S)-S-oxide + [thioredoxin]-dithiol; Xref=Rhea:RHEA:19993, Rhea:RHEA- CC COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, CC ChEBI:CHEBI:58772; EC=1.8.4.11; CC Evidence={ECO:0000256|ARBA:ARBA00001063}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L- CC methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol; CC Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, CC Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120, CC ChEBI:CHEBI:50058; EC=1.8.4.11; CC Evidence={ECO:0000256|ARBA:ARBA00001497}; CC -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family. CC {ECO:0000256|ARBA:ARBA00005591}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_002188026.1; XM_002187990.2. DR AlphaFoldDB; H0ZSW6; -. DR STRING; 59729.ENSTGUP00000013712; -. DR Ensembl; ENSTGUT00000013870.2; ENSTGUP00000013712.2; ENSTGUG00000013321.2. DR GeneID; 100221414; -. DR KEGG; tgu:100221414; -. DR CTD; 4482; -. DR GeneTree; ENSGT00390000003823; -. DR HOGENOM; CLU_031040_10_3_1; -. DR InParanoid; H0ZSW6; -. DR OMA; YCPVHAT; -. DR OrthoDB; 1120959at2759; -. DR TreeFam; TF353884; -. DR Proteomes; UP000007754; Chromosome 3. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0030496; C:midbody; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0036456; F:L-methionine-(S)-S-oxide reductase activity; IEA:TreeGrafter. DR GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:UniProtKB-EC. DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:TreeGrafter. DR FunFam; 3.30.1060.10:FF:000001; Peptide methionine sulfoxide reductase MsrA; 1. DR Gene3D; 3.30.1060.10; Peptide methionine sulphoxide reductase MsrA; 1. DR HAMAP; MF_01401; MsrA; 1. DR InterPro; IPR002569; Met_Sox_Rdtase_MsrA_dom. DR InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf. DR InterPro; IPR050162; MsrA_MetSO_reductase. DR NCBIfam; TIGR00401; msrA; 1. DR PANTHER; PTHR42799; MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE; 1. DR PANTHER; PTHR42799:SF2; MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE; 1. DR Pfam; PF01625; PMSR; 1. DR SUPFAM; SSF55068; Peptide methionine sulfoxide reductase; 1. PE 3: Inferred from homology; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..235 FT /note="peptide-methionine (S)-S-oxide reductase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5025589477" FT DOMAIN 68..220 FT /note="Peptide methionine sulphoxide reductase MsrA" FT /evidence="ECO:0000259|Pfam:PF01625" SQ SEQUENCE 235 AA; 26474 MW; 8FAE673C3C3BB88D CRC64; MSPRHRLHLL LFLRTLHGSA FGMGDQASRL PQAGEALPGR TQRMAVPDKH HVNGNRMVEP FPEGTQMALF GMGCFWGAER KFWRQKGVYS TQVGYAGGHT PNPTYKEVCS GRTGHTEAVR VVFEPQNISF EQLLKVFWEN HDPTQGMRQG NDVGTQYRSA IYTFSQEQME AALRSKEEYQ KVLTEEGFGP ITTEIREAPE FYYAEEYHQQ YLSKNPGGYC GLGGTGVSCP MGVRK //