ID H0Z408_TAEGU Unreviewed; 144 AA. AC H0Z408; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 12-SEP-2018, entry version 52. DE SubName: Full=Ubiquitin conjugating enzyme E2 D1 {ECO:0000313|Ensembl:ENSTGUP00000005302}; GN Name=UBE2D1 {ECO:0000313|Ensembl:ENSTGUP00000005302}; OS Taeniopygia guttata (Zebra finch) (Poephila guttata). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; OC Estrildidae; Estrildinae; Taeniopygia. OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000005302, ECO:0000313|Proteomes:UP000007754}; RN [1] {ECO:0000313|Ensembl:ENSTGUP00000005302, ECO:0000313|Proteomes:UP000007754} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20360741; DOI=10.1038/nature08819; RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W., RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A., RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P., RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., RA London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B., RA Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., RA Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M., RA Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P., RA Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T., RA Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A., RA Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E., RA Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D., RA Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H., RA Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J., RA Chinwalla A., Hou S., Mardis E.R., Wilson R.K.; RT "The genome of a songbird."; RL Nature 464:757-762(2010). RN [2] {ECO:0000313|Ensembl:ENSTGUP00000005302} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. CC {ECO:0000256|RuleBase:RU362109, ECO:0000256|SAAS:SAAS00805669}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ABQF01048110; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 59729.ENSTGUP00000005302; -. DR Ensembl; ENSTGUT00000005355; ENSTGUP00000005302; ENSTGUG00000005149. DR eggNOG; KOG0417; Eukaryota. DR eggNOG; COG5078; LUCA. DR GeneTree; ENSGT00910000143990; -. DR InParanoid; H0Z408; -. DR OMA; REWTANW; -. DR OrthoDB; EOG091G0GF8; -. DR TreeFam; TF101108; -. DR Reactome; R-TGU-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. DR Reactome; R-TGU-141430; Inactivation of APC/C via direct inhibition of the APC/C complex. DR Reactome; R-TGU-174048; APC/C:Cdc20 mediated degradation of Cyclin B. DR Reactome; R-TGU-174084; Autodegradation of Cdh1 by Cdh1:APC/C. DR Reactome; R-TGU-174154; APC/C:Cdc20 mediated degradation of Securin. DR Reactome; R-TGU-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1. DR Reactome; R-TGU-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A. DR Reactome; R-TGU-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. DR Reactome; R-TGU-176408; Regulation of APC/C activators between G1/S and early anaphase. DR Reactome; R-TGU-176409; APC/C:Cdc20 mediated degradation of mitotic proteins. DR Reactome; R-TGU-176412; Phosphorylation of the APC/C. DR Reactome; R-TGU-179409; APC-Cdc20 mediated degradation of Nek2A. DR Reactome; R-TGU-2467813; Separation of Sister Chromatids. DR Reactome; R-TGU-2559582; Senescence-Associated Secretory Phenotype (SASP). DR Reactome; R-TGU-69017; CDK-mediated phosphorylation and removal of Cdc6. DR Reactome; R-TGU-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes. DR Reactome; R-TGU-8866654; E3 ubiquitin ligases ubiquitinate target proteins. DR Reactome; R-TGU-9033241; Peroxisomal protein import. DR Reactome; R-TGU-937041; IKK complex recruitment mediated by RIP1. DR Reactome; R-TGU-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR Proteomes; UP000007754; Chromosome 6. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0061631; F:ubiquitin conjugating enzyme activity; IEA:Ensembl. DR GO; GO:1902916; P:positive regulation of protein polyubiquitination; IEA:Ensembl. DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR CDD; cd00195; UBCc; 1. DR Gene3D; 3.10.110.10; -; 1. DR InterPro; IPR000608; UBQ-conjugat_E2. DR InterPro; IPR023313; UBQ-conjugating_AS. DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD. DR Pfam; PF00179; UQ_con; 1. DR SUPFAM; SSF54495; SSF54495; 1. DR PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1. DR PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU362109}; KW Complete proteome {ECO:0000313|Proteomes:UP000007754}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU362109}; KW Reference proteome {ECO:0000313|Proteomes:UP000007754}; KW Transferase {ECO:0000256|SAAS:SAAS01018623}; KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU362109, KW ECO:0000256|SAAS:SAAS00805691}. FT DOMAIN 1 133 UBIQUITIN_CONJUGAT_2. FT {ECO:0000259|PROSITE:PS50127}. FT ACT_SITE 82 82 Glycyl thioester intermediate. FT {ECO:0000256|PROSITE-ProRule:PRU10133}. SQ SEQUENCE 144 AA; 16287 MW; 388FF758ED2F5E80 CRC64; KRIQKELSDL QRDPPAHCSA GPVGDDLFHW QATIMGPPDS AYQGGVFFLT VHFPTDYPFK PPKIAFTTKI YHPNINSNGS ICLDILRSQW SPALTVSKVL LSICSLLCDP NPDDPLVPDI AQIYKSDKEK YNRHAREWTQ KYAM //