ID H0YN42_HUMAN Unreviewed; 256 AA. AC H0YN42; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 19-MAR-2014, entry version 16. DE RecName: Full=Annexin; DE Flags: Fragment; GN Name=ANXA2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- DOMAIN: A pair of annexin repeats may form one binding site for CC calcium and phospholipid (By similarity). CC -!- SIMILARITY: Belongs to the annexin family. CC -!- SIMILARITY: Contains 3 annexin repeats. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC087385; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H0YN42; -. DR PRIDE; H0YN42; -. DR Ensembl; ENST00000559818; ENSP00000453859; ENSG00000182718. DR HGNC; HGNC:537; ANXA2. DR ChiTaRS; ANXA2; human. DR NextBio; 35524931; -. DR ArrayExpress; H0YN42; -. DR Bgee; H0YN42; -. DR GO; GO:0005938; C:cell cortex; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl. DR GO; GO:0044354; C:macropinosome; IEA:Ensembl. DR GO; GO:0035749; C:myelin sheath adaxonal region; IEA:Ensembl. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl. DR GO; GO:0043234; C:protein complex; IEA:Ensembl. DR GO; GO:0001726; C:ruffle; IEA:Ensembl. DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl. DR GO; GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl. DR GO; GO:0031982; C:vesicle; IEA:Ensembl. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW. DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl. DR GO; GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro. DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl. DR GO; GO:0007589; P:body fluid secretion; IEA:Ensembl. DR GO; GO:0071229; P:cellular response to acid; IEA:Ensembl. DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl. DR GO; GO:0042730; P:fibrinolysis; IEA:Ensembl. DR GO; GO:0043086; P:negative regulation of catalytic activity; IEA:GOC. DR GO; GO:0051099; P:positive regulation of binding; IEA:Ensembl. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0072661; P:protein targeting to plasma membrane; IEA:Ensembl. DR Gene3D; 1.10.220.10; -; 3. DR InterPro; IPR001464; Annexin. DR InterPro; IPR018502; Annexin_repeat. DR InterPro; IPR018252; Annexin_repeat_CS. DR InterPro; IPR002389; AnnexinII. DR PANTHER; PTHR10502:SF18; PTHR10502:SF18; 1. DR Pfam; PF00191; Annexin; 3. DR PRINTS; PR00196; ANNEXIN. DR PRINTS; PR00198; ANNEXINII. DR SMART; SM00335; ANX; 3. DR PROSITE; PS00223; ANNEXIN; 2. PE 2: Evidence at transcript level; KW Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; KW Reference proteome; Repeat. FT NON_TER 256 256 SQ SEQUENCE 256 AA; 28825 MW; 9AAF40EE90AD53AF CRC64; MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG DLENAF //