ID H0YJG0_HUMAN Unreviewed; 179 AA. AC H0YJG0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 19-JAN-2022, entry version 57. DE RecName: Full=Creatine kinase {ECO:0000256|ARBA:ARBA00012231}; DE EC=2.7.3.2 {ECO:0000256|ARBA:ARBA00012231}; DE Flags: Fragment; GN Name=CKB {ECO:0000313|Ensembl:ENSP00000451426}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451426, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000451426, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., RA Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0007829|PubMed:22905912} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22905912; DOI=10.1021/pr300539b; RA Rosenow A., Noben J.P., Jocken J., Kallendrusch S., Fischer-Posovszky P., RA Mariman E.C., Renes J.; RT "Resveratrol-induced changes of the human adipocyte secretion profile."; RL J. Proteome Res. 11:4733-4743(2012). RN [4] {ECO:0000313|Ensembl:ENSP00000451426} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family. CC {ECO:0000256|PROSITE-ProRule:PRU00843, ECO:0000256|RuleBase:RU000505}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00843}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL133367; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; H0YJG0; -. DR MaxQB; H0YJG0; -. DR PeptideAtlas; H0YJG0; -. DR PRIDE; H0YJG0; -. DR ProteomicsDB; 39321; -. DR Antibodypedia; 28; 833 antibodies from 39 providers. DR Ensembl; ENST00000553610; ENSP00000451426; ENSG00000166165. DR UCSC; uc059fqz.1; human. DR HGNC; HGNC:1991; CKB. DR OpenTargets; ENSG00000166165; -. DR VEuPathDB; HostDB:ENSG00000166165; -. DR GeneTree; ENSGT00950000182772; -. DR HOGENOM; CLU_019868_3_0_1; -. DR ChiTaRS; CKB; human. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000166165; Expressed in ventricular zone and 131 other tissues. DR ExpressionAtlas; H0YJG0; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004111; F:creatine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt. DR GO; GO:0046314; P:phosphocreatine biosynthetic process; IEA:InterPro. DR InterPro; IPR000749; ATP-guanido_PTrfase. DR InterPro; IPR022415; ATP-guanido_PTrfase_AS. DR InterPro; IPR022414; ATP-guanido_PTrfase_cat. DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom. DR PANTHER; PTHR11547; PTHR11547; 2. DR Pfam; PF00217; ATP-gua_Ptrans; 1. DR SUPFAM; SSF55931; SSF55931; 1. DR PROSITE; PS00112; PHOSPHAGEN_KINASE; 1. DR PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00843}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PROSITE- KW ProRule:PRU00843}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00843}; KW Proteomics identification {ECO:0007829|EPD:H0YJG0, KW ECO:0007829|MaxQB:H0YJG0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE- KW ProRule:PRU00843}. FT DOMAIN 1..165 FT /note="Phosphagen kinase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51510" FT NP_BIND 90..94 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843" FT NP_BIND 118..123 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843" FT BINDING 45 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00843" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000451426" SQ SEQUENCE 179 AA; 20147 MW; FB58305BFD2956AA CRC64; FLFDKPVSPL LLASGMARDW PDARGIWHND NKTFLVWVNE EDHLRVISMQ KGGNMKEIET LFKSKDYEFM WNPHLGYILT CPSNLGTGLR AGVHIKLPNL GKHEKFSEVL KRLRLQKRGT GGVDTAAVGG VFDVSNADRL GFSEVELVQM VVDGVKLLIE MEQRLEQGQA IDDLMPAQK //