ID H0YJG0_HUMAN Unreviewed; 179 AA. AC H0YJG0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 18-SEP-2019, entry version 45. DE SubName: Full=Creatine kinase B-type {ECO:0000313|Ensembl:ENSP00000451426}; DE Flags: Fragment; GN Name=CKB {ECO:0000313|Ensembl:ENSP00000451426}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000451426, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000451426, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000213|PubMed:22905912} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22905912; DOI=10.1021/pr300539b; RA Rosenow A., Noben J.P., Jocken J., Kallendrusch S., RA Fischer-Posovszky P., Mariman E.C., Renes J.; RT "Resveratrol-induced changes of the human adipocyte secretion RT profile."; RL J. Proteome Res. 11:4733-4743(2012). RN [4] {ECO:0000313|Ensembl:ENSP00000451426} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family. CC {ECO:0000256|PROSITE-ProRule:PRU00843, CC ECO:0000256|RuleBase:RU000505}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00843}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL133367; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; H0YJG0; -. DR MaxQB; H0YJG0; -. DR PeptideAtlas; H0YJG0; -. DR PRIDE; H0YJG0; -. DR ProteomicsDB; 39321; -. DR Ensembl; ENST00000553610; ENSP00000451426; ENSG00000166165. DR UCSC; uc059fqz.1; human. DR HGNC; HGNC:1991; CKB. DR OpenTargets; ENSG00000166165; -. DR GeneTree; ENSGT00950000182772; -. DR ChiTaRS; CKB; human. DR Proteomes; UP000005640; Chromosome 14. DR Bgee; ENSG00000166165; Expressed in 109 organ(s), highest expression level in right hemisphere of cerebellum. DR ExpressionAtlas; H0YJG0; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004111; F:creatine kinase activity; IEA:InterPro. DR GO; GO:0046314; P:phosphocreatine biosynthetic process; IEA:InterPro. DR InterPro; IPR000749; ATP-guanido_PTrfase. DR InterPro; IPR022415; ATP-guanido_PTrfase_AS. DR InterPro; IPR022414; ATP-guanido_PTrfase_cat. DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom. DR PANTHER; PTHR11547; PTHR11547; 1. DR Pfam; PF00217; ATP-gua_Ptrans; 1. DR SUPFAM; SSF55931; SSF55931; 1. DR PROSITE; PS00112; PHOSPHAGEN_KINASE; 1. DR PROSITE; PS51510; PHOSPHAGEN_KINASE_C; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00843}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Kinase {ECO:0000256|PROSITE-ProRule:PRU00843, KW ECO:0000256|RuleBase:RU000505}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00843}; KW Proteomics identification {ECO:0000213|EPD:H0YJG0, KW ECO:0000213|MaxQB:H0YJG0, ECO:0000213|PeptideAtlas:H0YJG0, KW ECO:0000213|ProteomicsDB:H0YJG0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transferase {ECO:0000256|PROSITE-ProRule:PRU00843, KW ECO:0000256|RuleBase:RU000505}. FT DOMAIN 1 165 Phosphagen kinase C-terminal. FT {ECO:0000259|PROSITE:PS51510}. FT NP_BIND 90 94 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00843}. FT NP_BIND 118 123 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00843}. FT BINDING 45 45 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00843}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000451426}. SQ SEQUENCE 179 AA; 20147 MW; FB58305BFD2956AA CRC64; FLFDKPVSPL LLASGMARDW PDARGIWHND NKTFLVWVNE EDHLRVISMQ KGGNMKEIET LFKSKDYEFM WNPHLGYILT CPSNLGTGLR AGVHIKLPNL GKHEKFSEVL KRLRLQKRGT GGVDTAAVGG VFDVSNADRL GFSEVELVQM VVDGVKLLIE MEQRLEQGQA IDDLMPAQK //