ID H0YCM0_HUMAN Unreviewed; 167 AA. AC H0YCM0; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 28-JUN-2023, entry version 75. DE SubName: Full=P21 (RAC1) activated kinase 1 {ECO:0000313|Ensembl:ENSP00000431906.1}; DE Flags: Fragment; GN Name=PAK1 {ECO:0000313|Ensembl:ENSP00000431906.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431906.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0007829|PubMed:16964243} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein phosphorylation RT analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000431906.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] {ECO:0007829|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [4] {ECO:0007829|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [5] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [6] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] {ECO:0007829|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [8] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [9] {ECO:0007829|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] {ECO:0000313|Ensembl:ENSP00000431906.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP000486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455420; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; H0YCM0; -. DR PeptideAtlas; H0YCM0; -. DR ProteomicsDB; 37108; -. DR Ensembl; ENST00000527457.5; ENSP00000431906.1; ENSG00000149269.10. DR UCSC; uc058fta.1; human. DR HGNC; HGNC:8590; PAK1. DR VEuPathDB; HostDB:ENSG00000149269; -. DR GeneTree; ENSGT00950000182988; -. DR HOGENOM; CLU_1606427_0_0_1; -. DR ChiTaRS; PAK1; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000149269; Expressed in middle temporal gyrus and 179 other tissues. DR ExpressionAtlas; H0YCM0; baseline and differential. DR Gene3D; 3.90.810.10; CRIB domain; 1. DR InterPro; IPR036936; CRIB_dom_sf. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:H0YCM0, KW ECO:0007829|MaxQB:H0YCM0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REGION 27..141 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 27..54 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 107..127 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000431906.1" SQ SEQUENCE 167 AA; 18633 MW; 1AF564B2B8275DC6 CRC64; XNITKSEQKK NPQAVLDVLE FYNSKKTSNS QKYMSFTDKS AEDYNSSNAL NVKAVSETPA VPPVSEDEDD DDDDATPPPV IAPRPEHTKS VYTRSVIEPL PVTPTRDVAT SPISPTENNT TPPDALTRNT EKQKKKPKMS DEEILEKLLT SWEMSCGLLW NTWLEAP //