ID H0YCG5_HUMAN Unreviewed; 244 AA. AC H0YCG5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 22-FEB-2023, entry version 70. DE SubName: Full=P21 (RAC1) activated kinase 1 {ECO:0000313|Ensembl:ENSP00000431541.1}; DE Flags: Fragment; GN Name=PAK1 {ECO:0000313|Ensembl:ENSP00000431541.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431541.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000431541.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000431541.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP000486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455420; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; H0YCG5; -. DR PeptideAtlas; H0YCG5; -. DR ProteomicsDB; 37054; -. DR Antibodypedia; 1132; 1446 antibodies from 50 providers. DR Ensembl; ENST00000533285.1; ENSP00000431541.1; ENSG00000149269.10. DR UCSC; uc058ftc.1; human. DR HGNC; HGNC:8590; PAK1. DR VEuPathDB; HostDB:ENSG00000149269; -. DR GeneTree; ENSGT00950000182988; -. DR HOGENOM; CLU_000288_63_23_1; -. DR ChiTaRS; PAK1; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000149269; Expressed in middle temporal gyrus and 179 other tissues. DR ExpressionAtlas; H0YCG5; baseline and differential. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR48015:SF20; SERINE/THREONINE-PROTEIN KINASE PAK 1; 1. DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1. DR Pfam; PF00069; Pkinase; 1. DR PIRSF; PIRSF000654; Integrin-linked_kinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|MaxQB:H0YCG5, KW ECO:0007829|PeptideAtlas:H0YCG5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 1..242 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000431541.1" SQ SEQUENCE 244 AA; 27205 MW; 17347819B884A069 CRC64; XASGTVYTAM DVATGQEVAI KQMNLQQQPK KELIINEILV MRENKNPNIV NYLDSYLVGD ELWVVMEYLA GGSLTDVVTE TCMDEGQIAA VCRECLQALE FLHSNQVIHR DIKSDNILLG MDGSVKLTDF GFCAQITPEQ SKRSTMVGTP YWMAPEVVTR KAYGPKVDIW SLGIMAIEMI EGEPPYLNEN PLRALYLIAT NGTPELQNPE KLSAIFRDFL NRCLEMDVEK RGSAKELLQA LVSG //