ID   H0YCG5_HUMAN            Unreviewed;       244 AA.
AC   H0YCG5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-SEP-2015, entry version 25.
DE   SubName: Full=Serine/threonine-protein kinase PAK 1 {ECO:0000313|Ensembl:ENSP00000431541};
DE   Flags: Fragment;
GN   Name=PAK1 {ECO:0000313|Ensembl:ENSP00000431541};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431541, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000431541, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000431541}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000431541}.
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DR   EMBL; AP000486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9606.ENSP00000278568; -.
DR   BindingDB; H0YCG5; -.
DR   Ensembl; ENST00000533285; ENSP00000431541; ENSG00000149269.
DR   HGNC; HGNC:8590; PAK1.
DR   GeneTree; ENSGT00800000124030; -.
DR   SignaLink; H0YCG5; -.
DR   ChiTaRS; PAK1; human.
DR   NextBio; 35521737; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; H0YCG5; baseline and differential.
DR   GO; GO:0005622; C:intracellular; IBA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0048365; F:Rac GTPase binding; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central.
DR   GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR002290; Ser/Thr_dual-sp_kinase.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H0YCG5,
KW   ECO:0000213|PeptideAtlas:H0YCG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000431541}.
SQ   SEQUENCE   244 AA;  27205 MW;  17347819B884A069 CRC64;
     XASGTVYTAM DVATGQEVAI KQMNLQQQPK KELIINEILV MRENKNPNIV NYLDSYLVGD
     ELWVVMEYLA GGSLTDVVTE TCMDEGQIAA VCRECLQALE FLHSNQVIHR DIKSDNILLG
     MDGSVKLTDF GFCAQITPEQ SKRSTMVGTP YWMAPEVVTR KAYGPKVDIW SLGIMAIEMI
     EGEPPYLNEN PLRALYLIAT NGTPELQNPE KLSAIFRDFL NRCLEMDVEK RGSAKELLQA
     LVSG
//