ID H0YCG5_HUMAN Unreviewed; 244 AA. AC H0YCG5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 24-JUN-2015, entry version 23. DE SubName: Full=Serine/threonine-protein kinase PAK 1 {ECO:0000313|Ensembl:ENSP00000431541}; DE Flags: Fragment; GN Name=PAK1 {ECO:0000313|Ensembl:ENSP00000431541}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000431541, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000431541, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000431541} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000431541}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP000486; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP003680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877441; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877442; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877443; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455420; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9606.ENSP00000278568; -. DR BindingDB; H0YCG5; -. DR Ensembl; ENST00000533285; ENSP00000431541; ENSG00000149269. DR HGNC; HGNC:8590; PAK1. DR GeneTree; ENSGT00790000122964; -. DR SignaLink; H0YCG5; -. DR ChiTaRS; PAK1; human. DR NextBio; 35521737; -. DR Proteomes; UP000005640; Chromosome 11. DR ExpressionAtlas; H0YCG5; baseline and differential. DR GO; GO:0005622; C:intracellular; IBA:GOC. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. DR GO; GO:0048365; F:Rac GTPase binding; IBA:GO_Central. DR GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central. DR GO; GO:0016477; P:cell migration; IBA:GO_Central. DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central. DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro. DR GO; GO:0007266; P:Rho protein signal transduction; IBA:GO_Central. DR GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:H0YCG5, KW ECO:0000213|PeptideAtlas:H0YCG5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000431541}. SQ SEQUENCE 244 AA; 27205 MW; 17347819B884A069 CRC64; XASGTVYTAM DVATGQEVAI KQMNLQQQPK KELIINEILV MRENKNPNIV NYLDSYLVGD ELWVVMEYLA GGSLTDVVTE TCMDEGQIAA VCRECLQALE FLHSNQVIHR DIKSDNILLG MDGSVKLTDF GFCAQITPEQ SKRSTMVGTP YWMAPEVVTR KAYGPKVDIW SLGIMAIEMI EGEPPYLNEN PLRALYLIAT NGTPELQNPE KLSAIFRDFL NRCLEMDVEK RGSAKELLQA LVSG //