ID H0Y3M3_HUMAN Unreviewed; 911 AA. AC H0Y3M3; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 26-FEB-2020, entry version 62. DE SubName: Full=Echinoderm microtubule-associated protein-like 3 {ECO:0000313|Ensembl:ENSP00000378256}; DE Flags: Fragment; GN Name=EML3 {ECO:0000313|Ensembl:ENSP00000378256}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378256, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000213|PubMed:16964243} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein phosphorylation RT analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000378256, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [4] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [5] {ECO:0000213|PubMed:20068231} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [6] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [8] {ECO:0000313|Ensembl:ENSP00000378256} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [9] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP001458; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; H0Y3M3; -. DR MaxQB; H0Y3M3; -. DR PeptideAtlas; H0Y3M3; -. DR PRIDE; H0Y3M3; -. DR ProteomicsDB; 34548; -. DR Ensembl; ENST00000394776; ENSP00000378256; ENSG00000149499. DR UCSC; uc001ntr.2; human. DR HGNC; HGNC:26666; EML3. DR OpenTargets; ENSG00000149499; -. DR eggNOG; KOG2106; Eukaryota. DR eggNOG; ENOG410XNTQ; LUCA. DR GeneTree; ENSGT00940000159589; -. DR SignaLink; H0Y3M3; -. DR ChiTaRS; EML3; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000149499; Expressed in left lobe of thyroid gland and 195 other tissues. DR ExpressionAtlas; H0Y3M3; baseline and differential. DR Gene3D; 2.130.10.10; -; 2. DR InterPro; IPR005108; HELP. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR017986; WD40_repeat_dom. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR Pfam; PF03451; HELP; 1. DR Pfam; PF00400; WD40; 3. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 1. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Proteomics identification {ECO:0000213|EPD:H0Y3M3, KW ECO:0000213|MaxQB:H0Y3M3, ECO:0000213|PeptideAtlas:H0Y3M3, KW ECO:0000213|ProteomicsDB:H0Y3M3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}. FT DOMAIN 587..757 FT /note="WD_REPEATS_REGION" FT /evidence="ECO:0000259|PROSITE:PS50294" FT REPEAT 587..619 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT REPEAT 716..749 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT REGION 39..203 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 787..823 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 865..890 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 9..36 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 72..87 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 107..127 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 143..159 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 166..187 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 793..807 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSP00000378256" SQ SEQUENCE 911 AA; 97529 MW; D6A867FDE15EB316 CRC64; XDGPAREALQ SLSQRLRVQE QEMELVKAAL AEALRLLRLQ VPPSSLQGSG TPAPPGDSSL AAPPGLPPTC TPSLVSRGTQ TETEVELKSS PGPPGLSNGP PAPQGASEEP SGTQSEGGGS SSSGAGSPGP PGILRPLQPP QRADTPRRNS SSSSSPSERP RQKLSRKAIS SANLLVRSGS TESRGGKDPL SSPGGPGSRR SNYNLEGISV KMFLRGRPIT MYIPSGIRSL EELPSGPPPE TLSLDWVYGY RGRDSRSNLF VLRSGEVVYF IACVVVLYRP GGGPGGPGGG GQRHYRGHTD CVRCLAVHPD GVRVASGQTA GVDKDGKPLQ PVVHIWDSET LLKLQEIGLG AFERGVGALA FSAADQGAFL CVVDDSNEHM LSVWDCSRGM KLAEIKSTND SVLAVGFNPR DSSCIVTSGK SHVHFWNWSG GVGVPGNGTL TRKQGVFGKY KKPKFIPCFV FLPDGDILTG DSEGNILTWG RSPSDSKTPG RGGAKETYGI VAQAHAHEGS IFALCLRRDG TVLSGGGRDR RLVQWGPGLV ALQEAEIPEH FGAVRAIAEG LGSELLVGTT KNALLRGDLA QGFSPVIQGH TDELWGLCTH PSQNRFLTCG HDRQLCLWDG ESHALAWSID LKETGLCADF HPSGAVVAVG LNTGRWLVLD TETREIVSDV IDGNEQLSVV RYSPDGLYLA IGSHDNVIYI YSVSSDGAKS SRFGRCMGHS SFITHLDWSK DGNFIMSNSG DYEILYWDVA GGCKQLKNRY ESRDREWATY TCVLGFHVYV PVRSCQGAEP HVRGPRQPRD QRPIHARRLA PRLAGRQGRQ HLPVASAGRW GRGAGARHAL SNPLPVPRLL PRRLIAAWRD RLARRRGPAP PCPSLAQSPT TRGRLFPGLT SRHSRSRIFL EGANGAPAHT V //