ID H0Y3M3_HUMAN Unreviewed; 911 AA. AC H0Y3M3; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 13-NOV-2013, sequence version 2. DT 08-MAY-2019, entry version 57. DE SubName: Full=Echinoderm microtubule-associated protein-like 3 {ECO:0000313|Ensembl:ENSP00000378256}; DE Flags: Fragment; GN Name=EML3 {ECO:0000313|Ensembl:ENSP00000378256}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378256, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000213|PubMed:16964243} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein RT phosphorylation analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000378256, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [3] {ECO:0000213|PubMed:18669648} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [4] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [5] {ECO:0000213|PubMed:20068231} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., RA Mann M.; RT "Quantitative phosphoproteomics reveals widespread full RT phosphorylation site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [6] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [7] {ECO:0000213|PubMed:21406692} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., RA Blagoev B.; RT "System-wide temporal characterization of the proteome and RT phosphoproteome of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [8] {ECO:0000313|Ensembl:ENSP00000378256} RP IDENTIFICATION. RG Ensembl; RL Submitted (JAN-2012) to UniProtKB. RN [9] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP001458; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EPD; H0Y3M3; -. DR jPOST; H0Y3M3; -. DR MaxQB; H0Y3M3; -. DR PeptideAtlas; H0Y3M3; -. DR PRIDE; H0Y3M3; -. DR Ensembl; ENST00000394776; ENSP00000378256; ENSG00000149499. DR UCSC; uc001ntr.2; human. DR HGNC; HGNC:26666; EML3. DR OpenTargets; ENSG00000149499; -. DR eggNOG; KOG2106; Eukaryota. DR eggNOG; ENOG410XNTQ; LUCA. DR GeneTree; ENSGT00940000159589; -. DR SignaLink; H0Y3M3; -. DR ChiTaRS; EML3; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000149499; Expressed in 196 organ(s), highest expression level in left lobe of thyroid gland. DR ExpressionAtlas; H0Y3M3; baseline and differential. DR Gene3D; 2.130.10.10; -; 2. DR InterPro; IPR005108; HELP. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR001680; WD40_repeat. DR InterPro; IPR017986; WD40_repeat_dom. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR Pfam; PF03451; HELP; 1. DR Pfam; PF00400; WD40; 3. DR SMART; SM00320; WD40; 7. DR SUPFAM; SSF50978; SSF50978; 1. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:H0Y3M3, KW ECO:0000213|MaxQB:H0Y3M3, ECO:0000213|PeptideAtlas:H0Y3M3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}. FT DOMAIN 587 757 WD_REPEATS_REGION. {ECO:0000259|PROSITE: FT PS50294}. FT REPEAT 587 619 WD. {ECO:0000256|PROSITE-ProRule: FT PRU00221}. FT REPEAT 716 749 WD. {ECO:0000256|PROSITE-ProRule: FT PRU00221}. FT COILED 9 36 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000378256}. SQ SEQUENCE 911 AA; 97529 MW; D6A867FDE15EB316 CRC64; XDGPAREALQ SLSQRLRVQE QEMELVKAAL AEALRLLRLQ VPPSSLQGSG TPAPPGDSSL AAPPGLPPTC TPSLVSRGTQ TETEVELKSS PGPPGLSNGP PAPQGASEEP SGTQSEGGGS SSSGAGSPGP PGILRPLQPP QRADTPRRNS SSSSSPSERP RQKLSRKAIS SANLLVRSGS TESRGGKDPL SSPGGPGSRR SNYNLEGISV KMFLRGRPIT MYIPSGIRSL EELPSGPPPE TLSLDWVYGY RGRDSRSNLF VLRSGEVVYF IACVVVLYRP GGGPGGPGGG GQRHYRGHTD CVRCLAVHPD GVRVASGQTA GVDKDGKPLQ PVVHIWDSET LLKLQEIGLG AFERGVGALA FSAADQGAFL CVVDDSNEHM LSVWDCSRGM KLAEIKSTND SVLAVGFNPR DSSCIVTSGK SHVHFWNWSG GVGVPGNGTL TRKQGVFGKY KKPKFIPCFV FLPDGDILTG DSEGNILTWG RSPSDSKTPG RGGAKETYGI VAQAHAHEGS IFALCLRRDG TVLSGGGRDR RLVQWGPGLV ALQEAEIPEH FGAVRAIAEG LGSELLVGTT KNALLRGDLA QGFSPVIQGH TDELWGLCTH PSQNRFLTCG HDRQLCLWDG ESHALAWSID LKETGLCADF HPSGAVVAVG LNTGRWLVLD TETREIVSDV IDGNEQLSVV RYSPDGLYLA IGSHDNVIYI YSVSSDGAKS SRFGRCMGHS SFITHLDWSK DGNFIMSNSG DYEILYWDVA GGCKQLKNRY ESRDREWATY TCVLGFHVYV PVRSCQGAEP HVRGPRQPRD QRPIHARRLA PRLAGRQGRQ HLPVASAGRW GRGAGARHAL SNPLPVPRLL PRRLIAAWRD RLARRRGPAP PCPSLAQSPT TRGRLFPGLT SRHSRSRIFL EGANGAPAHT V //