ID G9M5W5_MOUSE Unreviewed; 288 AA. AC G9M5W5; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 24-JUL-2024, entry version 46. DE SubName: Full=Forkhead box E3 {ECO:0000313|EMBL:BAL15371.1}; GN Name=Foxe3 {ECO:0000313|EMBL:BAL15371.1, ECO:0000313|MGI:MGI:1353569}; OS Mus musculus domesticus (western European house mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10092 {ECO:0000313|EMBL:BAL15371.1}; RN [1] {ECO:0000313|EMBL:BAL15371.1} RP NUCLEOTIDE SEQUENCE. RA Wada K., Maeda Y.Y., Watanabe K., Oshio T., Ueda T., Takahashi G., RA Yokohama M., Saito J., Seki Y., Takahama S., Ishii R., Shitara H., Taya C., RA Yonekawa H., Kikkawa Y.; RT "A deletion in a cis element of Foxe3 causes cataracts and microphthalmia RT in rct mice."; RL Mamm. Genome 22:693-702(2012). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00089}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB601886; BAL15371.1; -; mRNA. DR AlphaFoldDB; G9M5W5; -. DR AGR; MGI:1353569; -. DR MGI; MGI:1353569; Foxe3. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter. DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:TreeGrafter. DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter. DR CDD; cd20019; FH_FOXE; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR001766; Fork_head_dom. DR InterPro; IPR050211; FOX_domain-containing. DR InterPro; IPR018122; TF_fork_head_CS_1. DR InterPro; IPR030456; TF_fork_head_CS_2. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1. DR PANTHER; PTHR11829:SF156; FORKHEAD BOX PROTEIN E3; 1. DR Pfam; PF00250; Forkhead; 1. DR PRINTS; PR00053; FORKHEAD. DR SMART; SM00339; FH; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00657; FORK_HEAD_1; 1. DR PROSITE; PS00658; FORK_HEAD_2; 1. DR PROSITE; PS50039; FORK_HEAD_3; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}. FT DOMAIN 64..158 FT /note="Fork-head" FT /evidence="ECO:0000259|PROSITE:PS50039" FT DNA_BIND 64..158 FT /note="Fork-head" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089" FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 163..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 165..189 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 288 AA; 30542 MW; 1642593AEE25A6C5 CRC64; MDAQVAFSGF PALPSLTPSG PQLPTLAGAE PGREPEEVVG GGDAEPTAVP GPGKRRRRPL QRGKPPYSYI ALIAMALAHA PGRRLTLAAI YRFITERFAF YRDSPRKWQN SIRHNLTLND CFVKVPREPG NPGKGNYWTL DPAAADMFDN GSFLRRRKRF KRAELPAPPP PPPPFPYAPF PPPPAPASAP PARLFRLDSL LGLQPEPPGP VAPEPPCCAA PDAAFPPCAA AASPPLYSPA SERLGLPAPL PAEPLLALAG SAGALGPLGA GEAYLRQPGF APGLERYL //