ID G9KL43_MUSPF Unreviewed; 560 AA. AC G9KL43; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 07-OCT-2020, entry version 33. DE SubName: Full=Ras-like protein family, member T1 {ECO:0000313|EMBL:AES05622.1}; DE Flags: Fragment; OS Mustela putorius furo (European domestic ferret) (Mustela furo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae; OC Mustela. OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES05622.1}; RN [1] {ECO:0000313|EMBL:AES05622.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Lungs {ECO:0000313|EMBL:AES05622.1}; RX PubMed=23236062; DOI=10.1128/JVI.02476-12; RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F., RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M., RA Farooqui A., Kelvin D.J.; RT "Sequencing, annotation, and characterization of the influenza ferret RT infectome."; RL J. Virol. 87:1957-1966(2013). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single- CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}. CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single- CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}. CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family. CC {ECO:0000256|ARBA:ARBA00007981}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JP017024; AES05622.1; -; mRNA. DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR013566; EF_hand_assoc_1. DR InterPro; IPR013567; EF_hand_assoc_2. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR021181; Miro. DR InterPro; IPR020860; MIRO_dom. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001806; Small_GTPase. DR Pfam; PF08355; EF_assoc_1; 1. DR Pfam; PF08356; EF_assoc_2; 1. DR Pfam; PF00071; Ras; 1. DR PIRSF; PIRSF037488; Mt_Rho_GTPase; 1. DR SMART; SM00054; EFh; 2. DR SUPFAM; SSF47473; SSF47473; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR PROSITE; PS00018; EF_HAND_1; 1. DR PROSITE; PS50222; EF_HAND_2; 2. DR PROSITE; PS51423; MIRO; 2. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE- KW ProRule:PRU00448}; GTP-binding {ECO:0000256|ARBA:ARBA00023134}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}; KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT DOMAIN 1..158 FT /note="Miro" FT /evidence="ECO:0000259|PROSITE:PS51423" FT DOMAIN 165..200 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 285..320 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 393..560 FT /note="Miro" FT /evidence="ECO:0000259|PROSITE:PS51423" FT CA_BIND 178..189 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00448" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AES05622.1" FT NON_TER 560 FT /evidence="ECO:0000313|EMBL:AES05622.1" SQ SEQUENCE 560 AA; 64338 MW; 4091079F232D4A95 CRC64; LIMSLVSEEF PEEVPPRAEE ITIPADVTPE RVPTHIVDYS EAEQSDEQLH QEISQANVIC IVYAVNNKHS IDKVTSRWIP LINERTDKDS RLPLILVGNK SDLVEYSSME TILPIMNQYT EIETCVECSA KNLKNISELF YYAQKAVLHP TGPLYCPEEK EMKPACIKAL TRIFKISDQD NDGTLNDAEL NFFQRICFNT PLAPQALEDV KNVVRKHISD GVADSGLTLK GFLFLHTLFI QRGRHETTWT VLRRFGYDDD LDLTPEYLFP LLKIPPDCTT ELNHHAYLFL QSTFDKHDLD RDCALSPDEL KDLFKVFPYI PWGPDVNNTV CTNERGWITY QGFLSQWTLT TYLDVQRCLE YLGYLGYSIL TEQESQASAI TVTRDKKIDL QKKQTQRNVF RCNVIGMKNC GKSGVLQALL GRNLMRQKKI RDDHKSYYAI NTVYVYGQEK YLLLHDISES EFLTEAEIIC DVVCLVYDVS NPKSFEYCAR IFKQHFMDSR IPCLIIAAKS DLHEVKQDYS ISPADFCRKH KMPPPQAFTC NTADAPSKDI FVKLTTMAMY //