ID G9HPR6_NOTEU Unreviewed; 298 AA. AC G9HPR6; DT 22-FEB-2012, integrated into UniProtKB/TrEMBL. DT 22-FEB-2012, sequence version 1. DT 27-MAR-2024, entry version 43. DE RecName: Full=Homeobox protein Hox-B1 {ECO:0000256|ARBA:ARBA00040112}; GN Name=HOXB1 {ECO:0000313|EMBL:AEV59517.1}; OS Notamacropus eugenii (Tammar wallaby) (Macropus eugenii). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Diprotodontia; Macropodidae; Notamacropus. OX NCBI_TaxID=9315 {ECO:0000313|EMBL:AEV59517.1}; RN [1] {ECO:0000313|EMBL:AEV59517.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22708672; DOI=10.1186/1471-2164-13-251; RA Yu H., Lindsay J., Feng Z.P., Frankenberg S., Hu Y., Carone D., Shaw G., RA Pask A.J., O'Neill R., Papenfuss A.T., Renfree M.B.; RT "Evolution of coding and non-coding genes in HOX clusters of a marsupial."; RL BMC Genomics 13:251-251(2012). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. Acts on the CC anterior body structures. {ECO:0000256|ARBA:ARBA00037473}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily. CC {ECO:0000256|ARBA:ARBA00029448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN378719; AEV59517.1; -; Genomic_DNA. DR AlphaFoldDB; G9HPR6; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR046327; HXA1/B1/D1. DR PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1. DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}. FT DOMAIN 203..257 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 205..258 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 21..75 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 251..298 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..75 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 276..298 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 298 AA; 31921 MW; 42FED61765941C47 CRC64; MDYNRMNSFL EYALCNRGPG AYSSPTSYPP CSSSPGDSYG GEPRYGSGLP SPVLQQNPGY PTQTPSALGV PFTNSSPSGY TAPTCSPGYG PSQYYSLGQH DGDGGYFQQS GYGSQLGSLS ETYITGGTGA GPYPPPQPTY GTEQPSAFGP SYGDLLAEDK EPPCPSELSM PTTQTFDWMK VKRNPPKTAK VSDMGLGPAG GIRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR RMKQKKRERE GGLAPAVPPG SNKEAAGDAS SDQSACTSPE ASPNSVNS //