ID G8GPR3_HELAM Unreviewed; 140 AA. AC G8GPR3; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 24-JUL-2024, entry version 33. DE RecName: Full=unspecific monooxygenase {ECO:0000256|ARBA:ARBA00012109}; DE EC=1.14.14.1 {ECO:0000256|ARBA:ARBA00012109}; DE Flags: Fragment; OS Helicoverpa armigera (Cotton bollworm) (Heliothis armigera). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; OC Noctuidae; Heliothinae; Helicoverpa. OX NCBI_TaxID=29058 {ECO:0000313|EMBL:AET11928.1}; RN [1] {ECO:0000313|EMBL:AET11928.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=00429 {ECO:0000313|EMBL:AET11928.1}; RA Tao X.-Y., Mao Y.-B., Xue X.-Y., Chen X.-Y.; RT "Gossypol enhance herbivore insecticide tolerance involved multiple RT cytochrome P450."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein CC reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein CC reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA- CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, CC ChEBI:CHEBI:142491; EC=1.14.14.1; CC Evidence={ECO:0000256|ARBA:ARBA00001025}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004406}. Membrane CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004174}. CC -!- SIMILARITY: Belongs to the cytochrome P450 family. CC {ECO:0000256|ARBA:ARBA00010617}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN176571; AET11928.1; -; mRNA. DR AlphaFoldDB; G8GPR3; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro. DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. DR GO; GO:0046701; P:insecticide catabolic process; IEA:TreeGrafter. DR GO; GO:0046680; P:response to DDT; IEA:TreeGrafter. DR Gene3D; 1.10.630.10; Cytochrome P450; 1. DR InterPro; IPR001128; Cyt_P450. DR InterPro; IPR036396; Cyt_P450_sf. DR InterPro; IPR050476; Insect_CytP450_Detox. DR PANTHER; PTHR24292; CYTOCHROME P450; 1. DR PANTHER; PTHR24292:SF45; CYTOCHROME P450 6G1-RELATED; 1. DR Pfam; PF00067; p450; 1. DR SUPFAM; SSF48264; Cytochrome P450; 1. PE 2: Evidence at transcript level; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..140 FT /note="unspecific monooxygenase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003509937" FT NON_TER 140 FT /evidence="ECO:0000313|EMBL:AET11928.1" SQ SEQUENCE 140 AA; 16597 MW; 88A5E641864D14FD CRC64; MIFLLLLPIT LVLLYKYTTR NHDYWEKHNV KHEKPIPVFG TLYDNVFAKK SIIEVAADLY RQYPNEKVVG MFRGNTPELV IRDLEIVRKI LNVDFAYFYP RGIGRNPKYE PLFMNLFHAE GDSWKLLRQR LTSTFTTAKL //