ID G7Z069_ACISI Unreviewed; 499 AA. AC G7Z069; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 11-DEC-2019, entry version 33. DE SubName: Full=Hepatic lipase {ECO:0000313|EMBL:ACT22637.1}; GN Name=HL {ECO:0000313|EMBL:ACT22637.1}; OS Acipenser sinensis (Chinese sturgeon). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser. OX NCBI_TaxID=61970 {ECO:0000313|EMBL:ACT22637.1}; RN [1] {ECO:0000313|EMBL:ACT22637.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=20672411; DOI=10.3724/SP.J.1141.2010.03239; RA Huang Y., Liang X.F., Wang L., Li G.Z., Liu X.X., Yao Y.; RT "Molecular characterization and evolutional analysis of liportein lipase RT and hepatic lipase gene in Chinese Sturgeon and other six freshwater RT fishes."; RL Dong Wu Xue Yan Jiu 31:239-249(2010). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family. CC {ECO:0000256|RuleBase:RU004262, ECO:0000256|SAAS:SAAS00591292}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ436062; ACT22637.1; -; mRNA. DR ESTHER; acibe-a0a075ekg6; Hepatic_Lipase. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR CDD; cd00707; Pancreat_lipase_like; 1. DR Gene3D; 3.40.50.1820; -; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase/vitellogenin. DR InterPro; IPR002333; Lipase_hep. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR033906; Lipase_N. DR InterPro; IPR001024; PLAT/LH2_dom. DR InterPro; IPR036392; PLAT/LH2_dom_sf. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; PTHR11610; 1. DR PANTHER; PTHR11610:SF2; PTHR11610:SF2; 1. DR Pfam; PF00151; Lipase; 1. DR Pfam; PF01477; PLAT; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1. DR PRINTS; PR00824; HEPLIPASE. DR PRINTS; PR00821; TAGLIPASE. DR SMART; SM00308; LH2; 1. DR SUPFAM; SSF49723; SSF49723; 1. DR SUPFAM; SSF53474; SSF53474; 1. DR PROSITE; PS50095; PLAT; 1. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Secreted {ECO:0000256|SAAS:SAAS00288740}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..499 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003506593" FT DOMAIN 351..484 FT /note="PLAT" FT /evidence="ECO:0000259|PROSITE:PS50095" FT ACT_SITE 167 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT ACT_SITE 193 FT /note="Charge relay system" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT ACT_SITE 278 FT /note="Charge relay system" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-1" FT METAL 207 FT /note="Calcium; via carbonyl oxygen" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2" FT METAL 212 FT /note="Calcium" FT /evidence="ECO:0000256|PIRSR:PIRSR000865-2" SQ SEQUENCE 499 AA; 56318 MW; 6FE046C7CF76C8F1 CRC64; MGIVRGLVFI LFIYHISDAK RLLVNKTDTK DKSQPILKQK VHYVPKSNFR LYTSGDAMDD TCTILPFDSG TLDRCSFNST APLVIIVHGW SVDGMLESWV TKLAAALKSK LRYSNVVIAD WLSLAHQHYA IAVQNTRLVG QEIADLLEWL EESHQFSTEN VHLIGYSLGA HVSGFAGSYV SGSRNIGRIT GLDPAGPLFE GMSYTDRLSP DDANFVDAIH TFTQQHMGLS VGIKQPVAHY DFYPNGAPFQ PGCHIKNLYD HLSQYGLSGF QQNVKCAHER SVHLFIDSLL NDDKQSMAYW CNDNKSFDKG ICLDCRKNRC NTLGYNIKKV RTGTSKRLYL KTRSHMPYKV YHYQFKIQFI NQIAQLEPML TISLMGTKED VQNLPITLVE EITGNKTYTL LITLDTDIGD LMVLKFKWEG SAVWANIWNK VQTIMPWRKG GKGPELTVGR IRVKAGETQK KTSFCSQSDD STHILPAQEK TFVRCERNSN RGKKKTTLA //