ID G7YP97_CLOSI Unreviewed; 3016 AA. AC G7YP97; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 16-MAY-2012, entry version 5. DE SubName: Full=Carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase; GN ORFNames=CLF_105410; OS Clonorchis sinensis (Chinese liver fluke). OC Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; OC Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis. OX NCBI_TaxID=79923; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., RA Lv X., Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., RA Hu X., Xu J., Yu X.; RT "The draft genome of the carcinogenic human liver fluke Clonorchis RT sinensis."; RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Henan; RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W., RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L., RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., RA Xu J., Wu Z., Yu X.; RT "The genome and transcriptome sequence of Clonorchis sinensis provide RT insights into the carcinogenic liver fluke."; RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DF143923; GAA54778.1; -; Genomic_DNA. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro. DR GO; GO:0016874; F:ligase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro. DR GO; GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro. DR GO; GO:0006543; P:glutamine catabolic process; IEA:InterPro. DR Gene3D; G3DSA:3.30.1490.20; ATP_grasp_subdomain_1; 2. DR Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 2. DR Gene3D; G3DSA:1.10.1030.10; CarbamoylP_synth_lsu_oligo; 1. DR Gene3D; G3DSA:3.50.30.20; G3DSA:3.50.30.20; 1. DR Gene3D; G3DSA:3.40.50.1380; MGS-like_dom; 1. DR Gene3D; G3DSA:3.40.50.20; Pre-ATP_grasp; 2. DR HAMAP; MF_01209; CPSase_S_chain; 1; -. DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR InterPro; IPR002082; Asp_carbamoyltransf_euk. DR InterPro; IPR011761; ATP-grasp. DR InterPro; IPR013815; ATP_grasp_subdomain_1. DR InterPro; IPR013816; ATP_grasp_subdomain_2. DR InterPro; IPR006275; CarbamoylP_synth_lsu. DR InterPro; IPR005479; CarbamoylP_synth_lsu_ATP-bd. DR InterPro; IPR005483; CarbamoylP_synth_lsu_CPS-dom. DR InterPro; IPR005481; CarbamoylP_synth_lsu_N. DR InterPro; IPR005480; CarbamoylP_synth_lsu_oligo. DR InterPro; IPR006274; CarbamoylP_synth_ssu. DR InterPro; IPR002474; CarbamoylP_synth_ssu_N. DR InterPro; IPR002195; Dihydroorotase_CS. DR InterPro; IPR017926; GATASE_1. DR InterPro; IPR011059; Metal-dep_hydrolase_composite. DR InterPro; IPR011607; MGS-like_dom. DR InterPro; IPR016185; PreATP-grasp_fold. DR Pfam; PF00289; CPSase_L_chain; 2. DR Pfam; PF02786; CPSase_L_D2; 2. DR Pfam; PF02787; CPSase_L_D3; 1. DR Pfam; PF00988; CPSase_sm_chain; 1. DR Pfam; PF00117; GATase; 1. DR Pfam; PF02142; MGS; 1. DR Pfam; PF00185; OTCace; 1. DR Pfam; PF02729; OTCace_N; 1. DR PRINTS; PR00100; AOTCASE. DR PRINTS; PR00101; ATCASE. DR PRINTS; PR00098; CPSASE. DR SMART; SM01096; CPSase_L_D3; 1. DR SMART; SM01097; CPSase_sm_chain; 1. DR SMART; SM00851; MGS; 1. DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1. DR SUPFAM; SSF48108; CarbamoylP_synth_lsu_oligo; 1. DR SUPFAM; SSF52021; CP_synthsmall; 1. DR SUPFAM; SSF51338; Metalo_hydrolase; 1. DR SUPFAM; SSF52335; MGS-like_dom; 1. DR SUPFAM; SSF52440; PreATP-grasp-like; 2. DR TIGRFAMs; TIGR00670; Asp_carb_tr; 1. DR TIGRFAMs; TIGR01369; CPSaseII_lrg; 1. DR TIGRFAMs; TIGR01368; CPSaseIIsmall; 1. DR PROSITE; PS50975; ATP_GRASP; 2. DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1. DR PROSITE; PS00866; CPSASE_1; 2. DR PROSITE; PS00867; CPSASE_2; 2. DR PROSITE; PS00483; DIHYDROOROTASE_2; 1. DR PROSITE; PS51273; GATASE_TYPE_1; 1. PE 3: Inferred from homology; KW Complete proteome; Transferase. SQ SEQUENCE 3016 AA; 333210 MW; 4620F7501D4BD25A CRC64; MMSPRIATKR LQANCRARRT DQQPSDQQPI GVQTSAIDIR IIYVYIMRPR ASSSNPQLAP GCTLGRILFL LCINDVYGAI SHDERPVFSS SVVYGVARYK TQLRRAQHQQ QQTEVSGTTL KGCGRDFEEN SCGSVITLGM TVPCHHCTDM LRFMDSPVTV VKGAAIGEGI RSSVGAGSGK YGSESLPKRG NPHRSRSINT SESTPSISRY EQKNYTVTGL WVTWKIQKSN DDQRINGSRG RIPRNTRPLN QPIKETNPDL KATRKRPNNN RTITHKTVEL NTPNEENQTK ILRPATRCCF RSFISSDRSG GFHPLNPALT MSPRLVKKRL QFNCQAQRTD QQSISAPELP IFHDTARQIH ILQTHASFDC IQVDGIGQSS LQLNSNALYG QILIHKESGK ITPSNRRDRG NETNEKTRVI TPDATQSEVT QKASAGDQAF AQEREETAAD ETRLLSKLSP ERLVGDVPLH GEHTSLFGYR DRHGSMASVF NTDASLPRNR DLFETLIMKE KSRMDLVLPY YNHSKGCDIR KCLPPPNLTH WIITFQLWST FDFSCFAVKK LLLLFRNRNF RKSMNQCDVK QAEERSFGDS RPLGRLELHD GTVYDGFLYG SCGEAAGEVV FQTGMVGYIE SLTDPSYHSQ LLVLTYPSIG NYGVPSSQEA DEFGLPKWFE SNTIYARALI VSELCCDYSH FAAKRSLHEW LAENRVTCLS NIDTRELTLK LRQHGTVLGR IYPLPRGEPV PDWFDPASHN LVSHVSCRQE KIFNANGDVH VAVVDCGVKF NQIRCFCRKG AKVTLLPSSS DLSTRINEFD ALFISNGPGD PSHCTHLVDQ IRQWMKSNKP LFGICLGHQL VARAVGLETY KMKYGNRGHN QPCIHLETKR CFITSQNHGY SVDVSNLPEG WYELFRNVND HSNEGLAHRQ KPWMTVQFHP EHMAGPQDLE FLFDVFLDQV RSPSDMTLSE RLTKTITYDQ LRFEQLLAVR PNRPQKILLL GSGGLSIGQA GEFDYSGSQA LKALREEGVQ TLLINPNVAT VQTTSGMADK IFLLPVTPDC VARIIEAERP DGILIGFGGQ TGLTCGLALA YPDLNNKTDE TLTAPDDNDA PPLSILEQYD CRILGTPAAT IEITENRQMF ADAMHSIGEK VAPAAAATTV PATVDVANRL GFPVLIRAAF ALGGMGSGFA ENVEELEQLA TRALSQTPQI FIDKSLKGWK EVEYEVVRDA YNNCITVCNM ENIDPVGIHT GESIVVAPSQ TLSNVEYNML RSVAIKVACH LHIVGECNIQ FALDPNSLTY YIIEVNARLS RSSALASKAT GYPLAYIAAK LCLGRSLPEL SNVVTGGRTT ACFEPSLDYC VVKVPRWDLS KFTRVSRNIG SSMKSVGEVM AISRCFEEAI QKALRMSKPS VLGFTSGDHQ ADADILADPT DQRIFVLAAA LKDGWSVDKI HTLTQIDKWF LYRFAAIAEC EKELKTLRDG VLTKIVRLFE DPVTQSVSSS VLPSLHTLIR AKRLGFSDQQ IGEALHSSAL SVRETREKIY LGPLVRRVDT VAGEWPATTN YLYLSYADIP LAGVLQLGHS NELDRFPNKL QCRLNPSGKH DVSFEPQTQI MVLGSGVYRI GSSVEFDWCA VGCVRELRRL GWSSIMLNCN PETVSTDFDM CDRLYFDELS LERVLDIYKL ESAVGVIVSM GGQTPNNIAM PMHRLGVPIL GTSAESIDSA ENRFKFSRLL DCMGISQPRW RELTDVESAK SFCQQVGYPV LVRPSYVLSG AAMNVAYDPQ DLATYLSAAQ AISPEHPVVI SQFILDAKEI DVDAIAQAGR VVAIAVSEHV ENAGVHSGDA TLVTPPQDLN AETLDRIKQI VHSLADELQV SGPFNLQVIA KDNRLQIIEA NLRVSRSFPF VSKTLKYDFV AAATRCILGS ARDSICPPVT GSRTEAAYRH SSSRGFLEPT VDVLNGVPGY VGVKVPVFSF SRLLGADVLL GVEMVSTGEV ACFGRDRYEA YLLAQEAALF NTNGRLPRPK ESIFLSIGSY RHKKELLTSV SQLSRLGYKL YGSTGTADYY QTQGVPVIPV EWPYEDSDVA KQMYVHFGGA QNSDTDVRDR TVQEYLAEKQ FGLIVSLTMR KTGYRRPSAF VTRGYMTRRL AVETNVPLIT DVKLFKLLAE ALYRHYRGRT LPGKSKDSLL PLRRPDQPGV ECRLLPLHCI SSSQILYLPG LIDIHVHTRD PGHEYKEDWC TATVAALAGG IVAVLAMPNT NPAVVDEASL QFAMERAASR AYCDYGLFVG ATADNAGSVG QLGGHVVGLK MYLNETFSTL SLSGKLNIWK KHFETWPISK PICCHAEGET MAAVLLLAEL TGRSVHICHV ARKAEIELIR DAKARGLKVT CEVSPHHLFL TEDDLPDCGG WREVRPRLGT REDVQALWAN LDSIDCFATD HAPHLASEKA TSNAPPGFPG LESMLPLFLT AMCEGRLTLT DLIERLHVNP RRIFNLASDT NLLNAGDTLD RCMFDDTWVE VDMGAEWSLP GSYRVNSPYA EPPVTAPTLY TRAGWSPFAG RRVRGRVRRV VLRGELAFVD GRLLVKPGFG INLASQMTTV IASKAVLQEL PRVEVAEHAM ISSPVSPVPR TRFESYSERV QDDSVCIGGP SALVDVRSFG PSVPPTSGAP PSVNVSSWIE GISGHHLLSC EGFPKNALHR LFNLAHSFRQ AVLKNKPLDD ICRGKVMACL FFEPSTRTAN SFSVAMQRLG GSVIHFNESV SSLSKGETLS DTLRILASYC DCLVIRHPGK GEVQLAANSV LNRPIINAGD GVGEHPTQAM LDVFTIREEI GTVNGLTVTM VGDLANGRTV HSLARLLCLY NVRLRYVTHC EQLRMPEEVK QYVAARGIPQ EEMSSLEEAL PDTDVLYMTR VQAERIQSTD SMAVGQFVVT PELMTLAKKS GMIVMHPLPR VGEISPSFDS DPRAAYFRQA EYGITGLGEN SSAGQTVFWH AEYVPTSAAF EALGQPSSIP TLVLPVGGMA AWYRKGVTAE RLYGTT //