ID G5EFW8_CAEEL Unreviewed; 313 AA. AC G5EFW8; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 14-DEC-2022, entry version 95. DE RecName: Full=ADP/ATP translocase {ECO:0000256|RuleBase:RU368008}; DE AltName: Full=ADP,ATP carrier protein {ECO:0000256|RuleBase:RU368008}; GN Name=ant-1.3 {ECO:0000313|EMBL:CAA92472.1, GN ECO:0000313|WormBase:K01H12.2}; GN ORFNames=CELE_K01H12.2 {ECO:0000313|EMBL:CAA92472.1}, K01H12.2 GN {ECO:0000313|WormBase:K01H12.2}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA92472.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CAA92472.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92472.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). RN [2] {ECO:0000313|EMBL:CAA92472.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92472.1}; RA Sulson J.E., Waterston R.; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ACD12515.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18498090; DOI=10.1002/dvdy.21578; RA Farina F., Alberti A., Breuil N., Bolotin-Fukuhara M., Pinto M., RA Culetto E.; RT "Differential expression pattern of the four mitochondrial adenine RT nucleotide transporter ant genes and their roles during the development of RT Caenorhabditis elegans."; RL Dev. Dyn. 237:1668-1681(2008). RN [4] {ECO:0000313|EMBL:CAA92472.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92472.1}; RG WormBase Consortium; RA WormBase; RL Submitted (APR-2022) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. CC {ECO:0000256|RuleBase:RU368008}. CC -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU368008}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU368008}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368008}. CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family. CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU368008}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU512895; ACD12515.1; -; mRNA. DR EMBL; BX284604; CAA92472.1; -; Genomic_DNA. DR PIR; T23207; T23207. DR RefSeq; NP_501727.1; NM_069326.3. DR AlphaFoldDB; G5EFW8; -. DR SMR; G5EFW8; -. DR STRING; 6239.K01H12.2; -. DR PeptideAtlas; G5EFW8; -. DR EnsemblMetazoa; K01H12.2.1; K01H12.2.1; WBGene00010485. DR GeneID; 186855; -. DR KEGG; cel:CELE_K01H12.2; -. DR AGR; WB:WBGene00010485; -. DR CTD; 186855; -. DR WormBase; K01H12.2; CE03454; WBGene00010485; ant-1.3. DR eggNOG; KOG0749; Eukaryota. DR GeneTree; ENSGT00970000196037; -. DR HOGENOM; CLU_015166_12_0_1; -. DR OMA; NTHIMIS; -. DR OrthoDB; 870903at2759; -. DR Proteomes; UP000001940; Chromosome IV. DR Bgee; WBGene00010485; Expressed in adult organism and 3 other tissues. DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central. DR GO; GO:0005471; F:ATP:ADP antiporter activity; IBA:GO_Central. DR GO; GO:0140021; P:mitochondrial ADP transmembrane transport; IEA:InterPro. DR GO; GO:1990544; P:mitochondrial ATP transmembrane transport; IBA:GO_Central. DR GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IBA:GO_Central. DR Gene3D; 1.50.40.10; -; 1. DR InterPro; IPR002113; ADT_euk_type. DR InterPro; IPR002067; Mit_carrier. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR InterPro; IPR023395; Mt_carrier_dom_sf. DR PANTHER; PTHR45635; ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED; 1. DR Pfam; PF00153; Mito_carr; 3. DR PRINTS; PR00927; ADPTRNSLCASE. DR PRINTS; PR00926; MITOCARRIER. DR SUPFAM; SSF103506; Mitochondrial carrier; 1. DR PROSITE; PS50920; SOLCAR; 3. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368008}; KW Proteomics identification {ECO:0007829|EPD:G5EFW8, KW ECO:0007829|PeptideAtlas:G5EFW8}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000488}; KW Transmembrane helix {ECO:0000256|RuleBase:RU368008}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}. FT TRANSMEM 189..208 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368008" FT TRANSMEM 228..248 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU368008" SQ SEQUENCE 313 AA; 34384 MW; D1E455DDB463C984 CRC64; MTGGGDSKPI EKKKEDKKGF DTRKFLIDLA SGGTAAAVSK TAVAPIERVK LLLQVQDASL TIAADKRYKG IVDVLVRVPK EQGYAALWRG NLANVIRYFP TQALNFAFKD TYKNIFQKGL DKKKDFWKFF AGNLASGGAA GATSLCFVYP LDFARTRLAA DVGKANEREF KGLADCLVKI AKSDGPIGLY RGFFVSVQGI IIYRAAYFGM FDTAKMVFTA DGKKLNFFAA WAIAQVVTVG SGIISYPWDT VRRRMMMQSG RKDVLYKNTL DCAVKIIKNE GMSAMFKGAL SNVFRGTGGA LVLAIYDEIQ KFI //