ID G5EFI9_CAEEL Unreviewed; 277 AA. AC G5EFI9; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 22-FEB-2023, entry version 99. DE RecName: Full=Checkpoint protein {ECO:0000256|PIRNR:PIRNR011312}; GN Name=hus-1 {ECO:0000313|EMBL:CCD68357.1, GN ECO:0000313|WormBase:H26D21.1}; GN ORFNames=CELE_H26D21.1 {ECO:0000313|EMBL:CCD68357.1}, H26D21.1 GN {ECO:0000313|WormBase:H26D21.1}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:AAD22029.1}; RN [1] {ECO:0000313|EMBL:CCD68357.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68357.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). RN [2] {ECO:0000313|EMBL:AAD22029.1} RP NUCLEOTIDE SEQUENCE. RA Dean F.B., O'Donnell M.; RT "cDNA Cloning of a Homolog for Schizosaccharomyces pombe hus1 from C. RT elegans."; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CCD68357.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68357.1}; RA Sulson J.E., Waterston R.; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CCD68357.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68357.1}; RG WormBase Consortium; RA WormBase; RL Submitted (APR-2022) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the HUS1 family. {ECO:0000256|ARBA:ARBA00005563, CC ECO:0000256|PIRNR:PIRNR011312}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF117337; AAD22029.1; -; mRNA. DR EMBL; BX284601; CCD68357.1; -; Genomic_DNA. DR PIR; B87740; B87740. DR RefSeq; NP_491203.1; NM_058802.6. DR AlphaFoldDB; G5EFI9; -. DR SMR; G5EFI9; -. DR ComplexPortal; CPX-1615; Checkpoint clamp complex. DR IntAct; G5EFI9; 5. DR MINT; G5EFI9; -. DR STRING; 6239.H26D21.1; -. DR EnsemblMetazoa; H26D21.1.1; H26D21.1.1; WBGene00002042. DR GeneID; 171939; -. DR KEGG; cel:CELE_H26D21.1; -. DR AGR; WB:WBGene00002042; -. DR CTD; 171939; -. DR WormBase; H26D21.1; CE20999; WBGene00002042; hus-1. DR eggNOG; KOG3999; Eukaryota. DR GeneTree; ENSGT00390000000706; -. DR HOGENOM; CLU_087716_0_0_1; -. DR OMA; IIPASDW; -. DR OrthoDB; 5094542at2759; -. DR Reactome; R-CEL-176187; Activation of ATR in response to replication stress. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00002042; Expressed in germ line (C elegans) and 4 other tissues. DR GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central. DR GO; GO:0000785; C:chromatin; IDA:WormBase. DR GO; GO:0043073; C:germ cell nucleus; IDA:WormBase. DR GO; GO:0005730; C:nucleolus; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IDA:WormBase. DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central. DR GO; GO:0007059; P:chromosome segregation; IMP:WormBase. DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase. DR GO; GO:0000077; P:DNA damage checkpoint signaling; NAS:ComplexPortal. DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase. DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:WormBase. DR GO; GO:0044778; P:meiotic DNA integrity checkpoint signaling; IBA:GO_Central. DR GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central. DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central. DR GO; GO:0006289; P:nucleotide-excision repair; IMP:WormBase. DR GO; GO:0000723; P:telomere maintenance; IMP:WormBase. DR Gene3D; 3.70.10.10; -; 1. DR InterPro; IPR016580; Cell_cycle_HUS1. DR InterPro; IPR007150; Hus1/Mec3. DR PANTHER; PTHR12900:SF0; CHECKPOINT PROTEIN; 1. DR PANTHER; PTHR12900; MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1; 1. DR Pfam; PF04005; Hus1; 1. DR PIRSF; PIRSF011312; Cell_cycle_HUS1; 1. PE 2: Evidence at transcript level; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. SQ SEQUENCE 277 AA; 31449 MW; C0FB432742FEE292 CRC64; MKFSSLLQDT AAIDVFIKIL TSVSKLSKKR CCVKIEKNAL NFICCSGLHD GGSWFSLSIP YSSQIFRKFD MVGMNPRNEE QNLIYFELEI DSLVRVLPGG HCYLKLKLSK SQKDEPMLSV EVRNPEADIV SHQIPITIIL SKYWNSYSRP SIGHRKMSIS MPPPKMMSRF LHVFKNMNTR VVKLTASTSG DLRISTKIET GEIDVSFSDL QTNPSETDSQ EDTAKVQLMI RNISPLFQSF ANTRTRAKMN IISNRMAEFN FHNEDCVLSY IVGNVSD //