ID G5EES3_CAEEL Unreviewed; 1023 AA. AC G5EES3; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 13-SEP-2023, entry version 83. DE SubName: Full=Protein argonaute-2 {ECO:0000313|EMBL:CAR97837.1}; GN Name=alg-1 {ECO:0000313|EMBL:CAR97837.1, GN ECO:0000313|WormBase:F48F7.1b}; GN ORFNames=CELE_F48F7.1 {ECO:0000313|EMBL:CAR97837.1}, F48F7.1 GN {ECO:0000313|WormBase:F48F7.1b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAR97837.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CAR97837.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAR97837.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- SIMILARITY: Belongs to the argonaute family. CC {ECO:0000256|RuleBase:RU361178}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284606; CAR97837.1; -; Genomic_DNA. DR AlphaFoldDB; G5EES3; -. DR SMR; G5EES3; -. DR STRING; 6239.F48F7.1b; -. DR EPD; G5EES3; -. DR PaxDb; G5EES3; -. DR PeptideAtlas; G5EES3; -. DR EnsemblMetazoa; F48F7.1b.1; F48F7.1b.1; WBGene00000105. DR AGR; WB:WBGene00000105; -. DR WormBase; F48F7.1b; CE43299; WBGene00000105; alg-1. DR eggNOG; KOG1041; Eukaryota. DR InParanoid; G5EES3; -. DR OMA; CFAQQQH; -. DR OrthoDB; 3060088at2759; -. DR PhylomeDB; G5EES3; -. DR Reactome; R-CEL-203927; MicroRNA (miRNA) biogenesis. DR Reactome; R-CEL-426486; Small interfering RNA (siRNA) biogenesis. DR Reactome; R-CEL-426496; Post-transcriptional silencing by small RNAs. DR Proteomes; UP000001940; Chromosome X. DR Bgee; WBGene00000105; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues. DR ExpressionAtlas; G5EES3; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0000932; C:P-body; IDA:WormBase. DR GO; GO:0016442; C:RISC complex; IPI:WormBase. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:WormBase. DR GO; GO:0070551; F:endoribonuclease activity, cleaving siRNA-paired mRNA; IDA:WormBase. DR GO; GO:0035198; F:miRNA binding; IPI:WormBase. DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central. DR GO; GO:0016892; F:RNA endonuclease activity, producing 3'-phosphomonoesters; IDA:WormBase. DR GO; GO:0003727; F:single-stranded RNA binding; IDA:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase. DR GO; GO:0035196; P:miRNA processing; IMP:WormBase. DR GO; GO:0035279; P:miRNA-mediated gene silencing by mRNA destabilization; IDA:WormBase. DR GO; GO:0002119; P:nematode larval development; IGI:WormBase. DR GO; GO:0042659; P:regulation of cell fate specification; IGI:UniProtKB. DR GO; GO:0040034; P:regulation of development, heterochronic; IGI:UniProtKB. DR GO; GO:0070922; P:RISC complex assembly; IMP:WormBase. DR GO; GO:0090625; P:siRNA-mediated gene silencing by mRNA destabilization; IDA:WormBase. DR GO; GO:0040025; P:vulval development; IMP:WormBase. DR CDD; cd02846; PAZ_argonaute_like; 1. DR CDD; cd04657; Piwi_ago-like; 1. DR Gene3D; 3.40.50.2300; -; 1. DR Gene3D; 2.170.260.10; paz domain; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR014811; ArgoL1. DR InterPro; IPR032472; ArgoL2. DR InterPro; IPR032473; Argonaute_Mid_dom. DR InterPro; IPR032474; Argonaute_N. DR InterPro; IPR003100; PAZ_dom. DR InterPro; IPR036085; PAZ_dom_sf. DR InterPro; IPR003165; Piwi. DR InterPro; IPR045246; Piwi_ago-like. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR PANTHER; PTHR22891:SF174; ARGONAUTE-1, ISOFORM A; 1. DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1. DR Pfam; PF08699; ArgoL1; 1. DR Pfam; PF16488; ArgoL2; 1. DR Pfam; PF16487; ArgoMid; 1. DR Pfam; PF16486; ArgoN; 1. DR Pfam; PF02170; PAZ; 1. DR Pfam; PF02171; Piwi; 1. DR SMART; SM01163; DUF1785; 1. DR SMART; SM00949; PAZ; 1. DR SMART; SM00950; Piwi; 1. DR SUPFAM; SSF101690; PAZ domain; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS50821; PAZ; 1. DR PROSITE; PS50822; PIWI; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:G5EES3, KW ECO:0007829|PeptideAtlas:G5EES3}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. FT DOMAIN 395..512 FT /note="PAZ" FT /evidence="ECO:0000259|PROSITE:PS50821" FT DOMAIN 681..982 FT /note="Piwi" FT /evidence="ECO:0000259|PROSITE:PS50822" FT REGION 1..155 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..22 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 29..110 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1023 AA; 113110 MW; 9CC5DBDC4D104358 CRC64; MAAELNNTNT NESSNVASND PMSGGPQYLP GVMNSTIQQQ PQSATSSFLP SGPISSTSTS SQVVPTSGAT QQPPFPSAQA AASTALQNDL EEIFNSPPTQ PQTFSDVPQR QAGSLAPGVP IGNTSVSIGE PANTLGGGLP GGAPGQLPGG NQSGIQFQCP RRPNHGVEGR SILLRANHFA VRIPGGTIQH YQVDVTPDKC PRRVNREIIS CLISAFSKYF TNIRPVYDGK RNMYTREPLP IGRERMDFDV TLPGDSAVER QFSVSLKWVG QVSLSTLEDA MEGRVRQVPF EAVQAMDVIL RHLPSLKYTP VGRSFFSPPV PNASGVMAGS CPPQASGAVA GGAHSAGQYH AESKLGGGRE VWFGFHQSVR PSQWKMMLNI DVSATAFYRS MPVIEFIAEV LELPVQALAE RRALSDAQRV KFTKEIRGLK IEITHCGQMR RKYRVCNVTR RPAQTQTFPL QLETGQTIEC TVAKYFYDKY RIQLKYPHLP CLQVGQEQKH TYLPPEVCNI VPGQRCIKKL TDVQTSTMIK ATARSAPERE REISNLVRKA EFSADPFAHE FGITINPAMT EVKGRVLSAP KLLYGGRTRA TALPNQGVWD MRGKQFHTGI DVRVWAIACF AQQQHVKEND LRMFTNQLQR ISNDAGMPIV GNPCFCKYAV GVEQVEPMFK YLKQNYSGIQ LVVVVLPGKT PVYAEVKRVG DTVLGIATQC VQAKNAIRTT PQTLSNLCLK MNVKLGGVNS ILLPNVRPRI FNEPVIFFGC DITHPPAGDS RKPSIAAVVG SMDAHPSRYA ATVRVQQHRQ EIISDLTYMV RELLVQFYRN TRFKPARIVV YRDGVSEGQF FNVLQYELRA IREACMMLER GYQPGITFIA VQKRHHTRLF AVDKKDQVGK AYNIPPGTTV DVGITHPTEF DFYLCSHAGI QGTSRPSHYH VLWDDNNLTA DELQQLTYQM CHTYVRCTRS VSIPAPAYYA HLVAFRARYH LVDREHDSGE GSQPSGTSED TTLSNMARAV QVHPDANNVM YFA //