ID G5EES3_CAEEL Unreviewed; 1023 AA. AC G5EES3; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 07-NOV-2018, entry version 57. DE SubName: Full=Protein argonaute {ECO:0000313|EMBL:CAR97837.1}; GN Name=alg-1 {ECO:0000313|EMBL:CAR97837.1, GN ECO:0000313|WormBase:F48F7.1b}; GN ORFNames=CELE_F48F7.1 {ECO:0000313|EMBL:CAR97837.1}, F48F7.1 GN {ECO:0000313|WormBase:F48F7.1b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAR97837.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CAR97837.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAR97837.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- SIMILARITY: Belongs to the argonaute family. CC {ECO:0000256|RuleBase:RU361178}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284606; CAR97837.1; -; Genomic_DNA. DR RefSeq; NP_001257239.1; NM_001270310.1. DR UniGene; Cel.5579; -. DR ProteinModelPortal; G5EES3; -. DR SMR; G5EES3; -. DR STRING; 6239.F48F7.1b; -. DR EPD; G5EES3; -. DR PaxDb; G5EES3; -. DR PeptideAtlas; G5EES3; -. DR EnsemblMetazoa; F48F7.1b; F48F7.1b; WBGene00000105. DR GeneID; 181504; -. DR KEGG; cel:CELE_F48F7.1; -. DR CTD; 181504; -. DR WormBase; F48F7.1b; CE43299; WBGene00000105; alg-1. DR eggNOG; KOG1041; Eukaryota. DR eggNOG; ENOG410XP07; LUCA. DR GeneTree; ENSGT00760000119148; -. DR InParanoid; G5EES3; -. DR KO; K11593; -. DR OMA; SPDGYYH; -. DR OrthoDB; EOG091G020J; -. DR Reactome; R-CEL-426486; Small interfering RNA (siRNA) biogenesis. DR Reactome; R-CEL-426496; Post-transcriptional silencing by small RNAs. DR Proteomes; UP000001940; Chromosome X. DR Bgee; WBGene00000105; Expressed in 5 organ(s), highest expression level in multi-cellular organism. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0035068; C:micro-ribonucleoprotein complex; IPI:WormBase. DR GO; GO:0000932; C:P-body; IDA:WormBase. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:WormBase. DR GO; GO:0016892; F:endoribonuclease activity, producing 3'-phosphomonoesters; IDA:WormBase. DR GO; GO:0035198; F:miRNA binding; IPI:WormBase. DR GO; GO:0003727; F:single-stranded RNA binding; IDA:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase. DR GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase. DR GO; GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; IDA:WormBase. DR GO; GO:0002119; P:nematode larval development; IGI:WormBase. DR GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IMP:WormBase. DR GO; GO:0042659; P:regulation of cell fate specification; IGI:UniProtKB. DR GO; GO:0040034; P:regulation of development, heterochronic; IGI:UniProtKB. DR GO; GO:0070922; P:small RNA loading onto RISC; IMP:WormBase. DR GO; GO:0040025; P:vulval development; IMP:WormBase. DR Gene3D; 3.30.420.10; -; 1. DR InterPro; IPR014811; ArgoL1. DR InterPro; IPR032472; ArgoL2. DR InterPro; IPR032473; Argonaute_Mid_dom. DR InterPro; IPR032474; Argonaute_N. DR InterPro; IPR003100; PAZ_dom. DR InterPro; IPR036085; PAZ_dom_sf. DR InterPro; IPR003165; Piwi. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR Pfam; PF08699; ArgoL1; 1. DR Pfam; PF16488; ArgoL2; 1. DR Pfam; PF16487; ArgoMid; 1. DR Pfam; PF16486; ArgoN; 1. DR Pfam; PF02170; PAZ; 1. DR Pfam; PF02171; Piwi; 1. DR SMART; SM01163; DUF1785; 1. DR SMART; SM00949; PAZ; 1. DR SMART; SM00950; Piwi; 1. DR SUPFAM; SSF101690; SSF101690; 1. DR SUPFAM; SSF53098; SSF53098; 1. DR PROSITE; PS50821; PAZ; 1. DR PROSITE; PS50822; PIWI; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW Proteomics identification {ECO:0000213|EPD:G5EES3, KW ECO:0000213|PeptideAtlas:G5EES3}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}. FT DOMAIN 395 512 PAZ. {ECO:0000259|PROSITE:PS50821}. FT DOMAIN 681 982 Piwi. {ECO:0000259|PROSITE:PS50822}. SQ SEQUENCE 1023 AA; 113110 MW; 9CC5DBDC4D104358 CRC64; MAAELNNTNT NESSNVASND PMSGGPQYLP GVMNSTIQQQ PQSATSSFLP SGPISSTSTS SQVVPTSGAT QQPPFPSAQA AASTALQNDL EEIFNSPPTQ PQTFSDVPQR QAGSLAPGVP IGNTSVSIGE PANTLGGGLP GGAPGQLPGG NQSGIQFQCP RRPNHGVEGR SILLRANHFA VRIPGGTIQH YQVDVTPDKC PRRVNREIIS CLISAFSKYF TNIRPVYDGK RNMYTREPLP IGRERMDFDV TLPGDSAVER QFSVSLKWVG QVSLSTLEDA MEGRVRQVPF EAVQAMDVIL RHLPSLKYTP VGRSFFSPPV PNASGVMAGS CPPQASGAVA GGAHSAGQYH AESKLGGGRE VWFGFHQSVR PSQWKMMLNI DVSATAFYRS MPVIEFIAEV LELPVQALAE RRALSDAQRV KFTKEIRGLK IEITHCGQMR RKYRVCNVTR RPAQTQTFPL QLETGQTIEC TVAKYFYDKY RIQLKYPHLP CLQVGQEQKH TYLPPEVCNI VPGQRCIKKL TDVQTSTMIK ATARSAPERE REISNLVRKA EFSADPFAHE FGITINPAMT EVKGRVLSAP KLLYGGRTRA TALPNQGVWD MRGKQFHTGI DVRVWAIACF AQQQHVKEND LRMFTNQLQR ISNDAGMPIV GNPCFCKYAV GVEQVEPMFK YLKQNYSGIQ LVVVVLPGKT PVYAEVKRVG DTVLGIATQC VQAKNAIRTT PQTLSNLCLK MNVKLGGVNS ILLPNVRPRI FNEPVIFFGC DITHPPAGDS RKPSIAAVVG SMDAHPSRYA ATVRVQQHRQ EIISDLTYMV RELLVQFYRN TRFKPARIVV YRDGVSEGQF FNVLQYELRA IREACMMLER GYQPGITFIA VQKRHHTRLF AVDKKDQVGK AYNIPPGTTV DVGITHPTEF DFYLCSHAGI QGTSRPSHYH VLWDDNNLTA DELQQLTYQM CHTYVRCTRS VSIPAPAYYA HLVAFRARYH LVDREHDSGE GSQPSGTSED TTLSNMARAV QVHPDANNVM YFA //