ID G5EES3_CAEEL Unreviewed; 1023 AA. AC G5EES3; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 01-APR-2015, entry version 29. DE RecName: Full=Protein argonaute {ECO:0000256|RuleBase:RU361178}; GN Name=alg-1 {ECO:0000313|EMBL:CAR97837.1, GN ECO:0000313|WormBase:F48F7.1b}; GN ORFNames=CELE_F48F7.1 {ECO:0000313|EMBL:CAR97837.1}, F48F7.1 GN {ECO:0000313|WormBase:F48F7.1b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAR97837.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- FUNCTION: Probably involved in the RNA silencing pathway. CC {ECO:0000256|RuleBase:RU361178}. CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily. CC {ECO:0000256|RuleBase:RU361178}. CC -!- SIMILARITY: Contains 1 PAZ domain. CC {ECO:0000256|RuleBase:RU361178}. CC -!- SIMILARITY: Contains 1 PIWI domain. CC {ECO:0000256|RuleBase:RU361178}. CC -!- SIMILARITY: Contains Piwi domain. {ECO:0000256|SAAS:SAAS00097270}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284606; CAR97837.1; -; Genomic_DNA. DR RefSeq; NP_001257239.1; NM_001270310.1. DR UniGene; Cel.5579; -. DR ProteinModelPortal; G5EES3; -. DR SMR; G5EES3; 157-1023. DR EnsemblMetazoa; F48F7.1b; F48F7.1b; WBGene00000105. DR GeneID; 181504; -. DR KEGG; cel:CELE_F48F7.1; -. DR CTD; 181504; -. DR WormBase; F48F7.1b; CE43299; WBGene00000105; alg-1. DR GeneTree; ENSGT00760000119148; -. DR InParanoid; G5EES3; -. DR KO; K11593; -. DR OMA; FKHLKYT; -. DR Reactome; REACT_289839; Post-transcriptional silencing by small RNAs. DR Reactome; REACT_321514; MicroRNA (miRNA) biogenesis. DR Reactome; REACT_352724; Small interfering RNA (siRNA) biogenesis. DR Proteomes; UP000001940; Chromosome X. DR ExpressionAtlas; G5EES3; baseline. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0000932; C:cytoplasmic mRNA processing body; IDA:WormBase. DR GO; GO:0035068; C:micro-ribonucleoprotein complex; IPI:WormBase. DR GO; GO:0003725; F:double-stranded RNA binding; IDA:WormBase. DR GO; GO:0016892; F:endoribonuclease activity, producing 3'-phosphomonoesters; IDA:WormBase. DR GO; GO:0035198; F:miRNA binding; IPI:WormBase. DR GO; GO:0003727; F:single-stranded RNA binding; IDA:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase. DR GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase. DR GO; GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; IDA:WormBase. DR GO; GO:0002119; P:nematode larval development; IGI:WormBase. DR GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IMP:WormBase. DR GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IDA:GOC. DR GO; GO:0070922; P:small RNA loading onto RISC; IMP:WormBase. DR GO; GO:0040025; P:vulval development; IMP:WormBase. DR Gene3D; 3.30.420.10; -; 1. DR InterPro; IPR014811; DUF1785. DR InterPro; IPR003100; PAZ_dom. DR InterPro; IPR003165; Piwi. DR InterPro; IPR012337; RNaseH-like_dom. DR Pfam; PF08699; DUF1785; 1. DR Pfam; PF02170; PAZ; 1. DR Pfam; PF02171; Piwi; 1. DR SMART; SM00949; PAZ; 1. DR SMART; SM00950; Piwi; 1. DR SUPFAM; SSF101690; SSF101690; 2. DR SUPFAM; SSF53098; SSF53098; 1. DR PROSITE; PS50821; PAZ; 1. DR PROSITE; PS50822; PIWI; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU361178}. SQ SEQUENCE 1023 AA; 113110 MW; 9CC5DBDC4D104358 CRC64; MAAELNNTNT NESSNVASND PMSGGPQYLP GVMNSTIQQQ PQSATSSFLP SGPISSTSTS SQVVPTSGAT QQPPFPSAQA AASTALQNDL EEIFNSPPTQ PQTFSDVPQR QAGSLAPGVP IGNTSVSIGE PANTLGGGLP GGAPGQLPGG NQSGIQFQCP RRPNHGVEGR SILLRANHFA VRIPGGTIQH YQVDVTPDKC PRRVNREIIS CLISAFSKYF TNIRPVYDGK RNMYTREPLP IGRERMDFDV TLPGDSAVER QFSVSLKWVG QVSLSTLEDA MEGRVRQVPF EAVQAMDVIL RHLPSLKYTP VGRSFFSPPV PNASGVMAGS CPPQASGAVA GGAHSAGQYH AESKLGGGRE VWFGFHQSVR PSQWKMMLNI DVSATAFYRS MPVIEFIAEV LELPVQALAE RRALSDAQRV KFTKEIRGLK IEITHCGQMR RKYRVCNVTR RPAQTQTFPL QLETGQTIEC TVAKYFYDKY RIQLKYPHLP CLQVGQEQKH TYLPPEVCNI VPGQRCIKKL TDVQTSTMIK ATARSAPERE REISNLVRKA EFSADPFAHE FGITINPAMT EVKGRVLSAP KLLYGGRTRA TALPNQGVWD MRGKQFHTGI DVRVWAIACF AQQQHVKEND LRMFTNQLQR ISNDAGMPIV GNPCFCKYAV GVEQVEPMFK YLKQNYSGIQ LVVVVLPGKT PVYAEVKRVG DTVLGIATQC VQAKNAIRTT PQTLSNLCLK MNVKLGGVNS ILLPNVRPRI FNEPVIFFGC DITHPPAGDS RKPSIAAVVG SMDAHPSRYA ATVRVQQHRQ EIISDLTYMV RELLVQFYRN TRFKPARIVV YRDGVSEGQF FNVLQYELRA IREACMMLER GYQPGITFIA VQKRHHTRLF AVDKKDQVGK AYNIPPGTTV DVGITHPTEF DFYLCSHAGI QGTSRPSHYH VLWDDNNLTA DELQQLTYQM CHTYVRCTRS VSIPAPAYYA HLVAFRARYH LVDREHDSGE GSQPSGTSED TTLSNMARAV QVHPDANNVM YFA //