ID G5EEG9_CAEEL Unreviewed; 399 AA. AC G5EEG9; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 05-JUN-2019, entry version 65. DE SubName: Full=Helix Loop Helix {ECO:0000313|EMBL:CAA95837.1}; GN Name=hlh-2 {ECO:0000313|EMBL:CAA95837.1, GN ECO:0000313|WormBase:M05B5.5a}; GN ORFNames=CELE_M05B5.5 {ECO:0000313|EMBL:CAA95837.1}, M05B5.5 GN {ECO:0000313|WormBase:M05B5.5a}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA95837.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CAA95837.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA95837.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CAA95837.1; -; Genomic_DNA. DR PIR; T18853; T18853. DR RefSeq; NP_001021581.1; NM_001026410.3. DR SMR; G5EEG9; -. DR IntAct; G5EEG9; 16. DR STRING; 6239.M05B5.5a; -. DR EPD; G5EEG9; -. DR PaxDb; G5EEG9; -. DR PeptideAtlas; G5EEG9; -. DR EnsemblMetazoa; M05B5.5a; M05B5.5a; WBGene00001949. DR GeneID; 172458; -. DR KEGG; cel:CELE_M05B5.5; -. DR CTD; 172458; -. DR WormBase; M05B5.5a; CE06191; WBGene00001949; hlh-2. DR eggNOG; KOG3910; Eukaryota. DR eggNOG; ENOG410XYUA; LUCA. DR GeneTree; ENSGT00940000168822; -. DR InParanoid; G5EEG9; -. DR KO; K15603; -. DR OMA; DAMSSMY; -. DR OrthoDB; 1442255at2759; -. DR Reactome; R-CEL-525793; Myogenesis. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00001949; Expressed in 5 organ(s), highest expression level in multi-cellular organism. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0005634; C:nucleus; IDA:WormBase. DR GO; GO:0090575; C:RNA polymerase II transcription factor complex; IDA:WormBase. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0043425; F:bHLH transcription factor binding; IPI:WormBase. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:WormBase. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:WormBase. DR GO; GO:0042803; F:protein homodimerization activity; IPI:WormBase. DR GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:WormBase. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase. DR GO; GO:0010171; P:body morphogenesis; IMP:WormBase. DR GO; GO:0001708; P:cell fate specification; IMP:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase. DR GO; GO:0008406; P:gonad development; IMP:WormBase. DR GO; GO:0035262; P:gonad morphogenesis; IMP:WormBase. DR GO; GO:0002119; P:nematode larval development; IMP:WormBase. DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase. DR GO; GO:0014018; P:neuroblast fate specification; IMP:WormBase. DR GO; GO:0048666; P:neuron development; IGI:WormBase. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0043068; P:positive regulation of programmed cell death; IMP:WormBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase. DR GO; GO:0000003; P:reproduction; IMP:WormBase. DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:WormBase. DR GO; GO:0040025; P:vulval development; IMP:WormBase. DR CDD; cd00083; HLH; 1. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW Proteomics identification {ECO:0000213|PeptideAtlas:G5EEG9}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. FT DOMAIN 302 356 BHLH. {ECO:0000259|PROSITE:PS50888}. FT REGION 66 119 Disordered. {ECO:0000256|MobiDB-lite: FT G5EEG9}. FT REGION 208 315 Disordered. {ECO:0000256|MobiDB-lite: FT G5EEG9}. FT REGION 371 399 Disordered. {ECO:0000256|MobiDB-lite: FT G5EEG9}. FT COMPBIAS 248 291 Polar. {ECO:0000256|MobiDB-lite:G5EEG9}. FT COMPBIAS 292 315 Polyampholyte. {ECO:0000256|MobiDB-lite: FT G5EEG9}. FT COMPBIAS 372 386 Polyampholyte. {ECO:0000256|MobiDB-lite: FT G5EEG9}. SQ SEQUENCE 399 AA; 43193 MW; 8E139D03E597863B CRC64; MADPNSQLTS ATTVATAAIA QPQVMLPNAY DYPYNIDPTT IQMPDYWSGY HLNPYPPMQT TDIDYSSAFL PTHPPTETPA SVAAPTSATS DIKPIHATSS TSTTAPSTAP APTSTTDVLE LKPTTAPATN SAETSAIVAP QPLTNLTAPI DAMSSMYTWP QTYPGYLPPS EDNKASEAVN PYISIPPTYT FGADPSVADF SSYQQQLAGQ PNGLGGDTNL VDYNHQFPPA GMSPHFDPNG YPGMTGMPPG SSASSVRNDK SASRATSRRR VQGPPSSGIP TRHSSSSRLS DNESMSDDKD TDRRSQNNAR ERVRVRDINS AFKELGRMCT QHNQNTERNQ TKLGILHNAV SVITQLEEQV RQRNMNPKVM AGMKRKPDDD KMKMLDDNAP SAQFGHPRF //