ID G5EEG9_CAEEL Unreviewed; 399 AA. AC G5EEG9; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 16-SEP-2015, entry version 34. DE SubName: Full=HLH-2, isoform a {ECO:0000313|EMBL:CAA95837.1}; GN Name=hlh-2 {ECO:0000313|EMBL:CAA95837.1, GN ECO:0000313|WormBase:M05B5.5a}; GN ORFNames=CELE_M05B5.5 {ECO:0000313|EMBL:CAA95837.1}, M05B5.5 GN {ECO:0000313|WormBase:M05B5.5a}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA95837.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC {ECO:0000256|RuleBase:RU000367}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CAA95837.1; -; Genomic_DNA. DR PIR; T18853; T18853. DR RefSeq; NP_001021581.1; NM_001026410.3. DR UniGene; Cel.5062; -. DR ProteinModelPortal; G5EEG9; -. DR SMR; G5EEG9; 303-363. DR IntAct; G5EEG9; 17. DR STRING; 6239.M05B5.5a; -. DR PRIDE; G5EEG9; -. DR EnsemblMetazoa; M05B5.5a; M05B5.5a; WBGene00001949. DR GeneID; 172458; -. DR KEGG; cel:CELE_M05B5.5; -. DR CTD; 172458; -. DR WormBase; M05B5.5a; CE06191; WBGene00001949; hlh-2. DR GeneTree; ENSGT00510000046438; -. DR InParanoid; G5EEG9; -. DR KO; K15603; -. DR OMA; DAMSSMY; -. DR OrthoDB; EOG71ZP1Z; -. DR Reactome; R-CEL-375170; CDO in myogenesis. DR NextBio; 875589; -. DR Proteomes; UP000001940; Chromosome I. DR ExpressionAtlas; G5EEG9; baseline. DR GO; GO:0005737; C:cytoplasm; IDA:WormBase. DR GO; GO:0005634; C:nucleus; IDA:WormBase. DR GO; GO:0090575; C:RNA polymerase II transcription factor complex; IDA:WormBase. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0043425; F:bHLH transcription factor binding; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:WormBase. DR GO; GO:0042803; F:protein homodimerization activity; IPI:WormBase. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:WormBase. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:WormBase. DR GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:WormBase. DR GO; GO:0010171; P:body morphogenesis; IMP:WormBase. DR GO; GO:0001708; P:cell fate specification; IMP:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase. DR GO; GO:0008406; P:gonad development; IMP:WormBase. DR GO; GO:0035262; P:gonad morphogenesis; IMP:WormBase. DR GO; GO:0002119; P:nematode larval development; IMP:WormBase. DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase. DR GO; GO:0014018; P:neuroblast fate specification; IMP:WormBase. DR GO; GO:0048666; P:neuron development; IGI:WormBase. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0043068; P:positive regulation of programmed cell death; IMP:WormBase. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:WormBase. DR GO; GO:0000003; P:reproduction; IMP:WormBase. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; IDA:WormBase. DR GO; GO:0040025; P:vulval development; IMP:WormBase. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW Proteomics identification {ECO:0000213|PeptideAtlas:G5EEG9}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. SQ SEQUENCE 399 AA; 43193 MW; 8E139D03E597863B CRC64; MADPNSQLTS ATTVATAAIA QPQVMLPNAY DYPYNIDPTT IQMPDYWSGY HLNPYPPMQT TDIDYSSAFL PTHPPTETPA SVAAPTSATS DIKPIHATSS TSTTAPSTAP APTSTTDVLE LKPTTAPATN SAETSAIVAP QPLTNLTAPI DAMSSMYTWP QTYPGYLPPS EDNKASEAVN PYISIPPTYT FGADPSVADF SSYQQQLAGQ PNGLGGDTNL VDYNHQFPPA GMSPHFDPNG YPGMTGMPPG SSASSVRNDK SASRATSRRR VQGPPSSGIP TRHSSSSRLS DNESMSDDKD TDRRSQNNAR ERVRVRDINS AFKELGRMCT QHNQNTERNQ TKLGILHNAV SVITQLEEQV RQRNMNPKVM AGMKRKPDDD KMKMLDDNAP SAQFGHPRF //