ID G5EDF4_CAEEL Unreviewed; 1161 AA. AC G5EDF4; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 07-APR-2021, entry version 87. DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035}; GN Name=abts-1 {ECO:0000313|EMBL:CAQ76479.1, GN ECO:0000313|WormBase:F52B5.1b}; GN ORFNames=1I874 {ECO:0000313|EMBL:ABA18179.1}, CELE_F52B5.1 GN {ECO:0000313|EMBL:CAQ76479.1}, F52B5.1 GN {ECO:0000313|WormBase:F52B5.1b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:ABA18179.1}; RN [1] {ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). RN [2] {ECO:0000313|EMBL:CAQ76479.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAQ76479.1}; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science, e1252229 282:2012-2018(1998). RN [3] {ECO:0000313|EMBL:CAQ76479.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAQ76479.1}; RA Sulson J.E., Waterston R.; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ABA18179.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15814591; DOI=10.1152/ajpcell.00071.2005; RA Sherman T., Chernova M.N., Clark J.S., Jiang L., Alper S.L., Nehrke K.; RT "The abts and sulp families of anion transporters from Caenorhabditis RT elegans."; RL Am. J. Physiol. 289:C341-C351(2005). RN [5] {ECO:0000313|EMBL:ABA18179.1} RP NUCLEOTIDE SEQUENCE. RA Kohara Y., Shin-i T., Suzuki Y., Sugano S., Thierry-Mieg D., RA Thierry-Mieg J.; RT "The Caenorhabditis elegans transcriptome project, a complementary view of RT the genome."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:CAQ76479.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAQ76479.1}; RG WormBase Consortium; RA WormBase; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU362035}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}. CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family. CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ178237; ABA18179.1; -; mRNA. DR EMBL; BX284601; CAQ76479.1; -; Genomic_DNA. DR RefSeq; NP_001129776.1; NM_001136304.2. DR EnsemblMetazoa; F52B5.1b.1; F52B5.1b.1; WBGene00009920. DR GeneID; 172613; -. DR CTD; 172613; -. DR WormBase; F52B5.1b; CE42722; WBGene00009920; abts-1. DR GeneTree; ENSGT00940000168946; -. DR HOGENOM; CLU_002289_5_2_1; -. DR OMA; WSPIIAV; -. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00009920; Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues. DR GO; GO:0005887; C:integral component of plasma membrane; IC:WormBase. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0045202; C:synapse; IEA:GOC. DR GO; GO:0015301; F:anion:anion antiporter activity; IDA:WormBase. DR GO; GO:0015108; F:chloride transmembrane transporter activity; IDA:WormBase. DR GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. DR GO; GO:0008510; F:sodium:bicarbonate symporter activity; IBA:GO_Central. DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0015701; P:bicarbonate transport; IBA:GO_Central. DR GO; GO:0050801; P:ion homeostasis; IBA:GO_Central. DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central. DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:WormBase. DR GO; GO:0046685; P:response to arsenic-containing substance; IMP:WormBase. DR GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:WormBase. DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central. DR Gene3D; 3.40.930.10; -; 1. DR InterPro; IPR013769; Band3_cytoplasmic_dom. DR InterPro; IPR011531; HCO3_transpt_C. DR InterPro; IPR003020; HCO3_transpt_euk. DR InterPro; IPR003024; Na/HCO3_transpt. DR InterPro; IPR016152; PTrfase/Anion_transptr. DR PANTHER; PTHR11453; PTHR11453; 1. DR Pfam; PF07565; Band_3_cyto; 1. DR Pfam; PF00955; HCO3_cotransp; 1. DR PRINTS; PR01231; HCO3TRNSPORT. DR PRINTS; PR01232; NAHCO3TRSPRT. DR SUPFAM; SSF55804; SSF55804; 1. DR TIGRFAMs; TIGR00834; ae; 1. PE 1: Evidence at protein level; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU362035}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035}; KW Proteomics identification {ECO:0007829|EPD:G5EDF4, KW ECO:0007829|PeptideAtlas:G5EDF4}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU362035}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU362035}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}. FT TRANSMEM 471..492 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 501..519 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 556..581 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 588..606 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 690..707 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 727..745 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 775..794 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 815..841 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 875..894 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT TRANSMEM 901..920 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU362035" FT DOMAIN 109..387 FT /note="Band_3_cyto" FT /evidence="ECO:0000259|Pfam:PF07565" FT DOMAIN 437..952 FT /note="HCO3_cotransp" FT /evidence="ECO:0000259|Pfam:PF00955" FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 221..265 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1093..1161 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 19..33 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 43..57 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 236..260 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1093..1109 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1129..1144 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1146..1161 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1161 AA; 129328 MW; 5DE73288A79FFE5F CRC64; MEEETDEESP AKIARSRSCE PPGSSSRSRE SRGSLWMSMG VHVENSRRRR MSKARRESQS IELSSLAPGT RVMFLLKEKE NTPALFTEMG ELNNEEWRET ARWVKFEEDV EQGGNRWSKP HVATLSLHSL FQLRSCIMNG HFMNDLAETD IPSIFNAVIE NLEKSGDLPS ENREELREIL LRKHVHQYEQ AKKNGAGGEK GGFLSTVRSI SDIGKSFSHG KNLSKIEEKP EGPVTSQTAG APSGSSNQLT LPTVESVPKD ISSEESSKGN LHFLKKLPAG VEASNVLIGE VDFLTRHICC FIRLKNANQL GDLTEVPVPT RFIFLLLGPT GHGQQYREIG RAIATLMADE IFHDVAYGAR DVDDLLDGID EFLDQVTVLP PGEWDPNIRI EPPSKLPSQE KRKQIGQELL VEPSSHKHVK KVVEEEEIHS HGDDPALKRT GKLFGGLILD IKRKAPHFVS DFTDAFNLQC LASICFMYFG LLAPIVTFGG LLEEATHQRM AAMENLFGGA LCGVIYHFFA GQPLTIVGST GPVLVFETIV FDFCHRFGIV YLSFRFWVHV WTAVIIFLMV VTDASALVSF ITRFTEESFA TLIAVIFIYE AIMKLVKIKG QLDMINYSRD FVEGGFCSCV PPIGKPSVSP DHARLVIKST GLPIAFNDTF IDYTAANLTD CRTIGGSFDG TTCFPLYDKL LMSILLTVGT FFLATTLKKM RNSCYFPSSV RQLLSDFAVM IAIASMTFVD IFVGVNTPKL NVPSTFRPTW EGRGWFIPPF DANEWWTAPL AILPALLACI LIFMDQQITT VIVNRKENKL KKGCGYHLDL LVLSVSILMV GFLGLPIYVA ATVLSINHIN SLKVESECKA PGEVAQFVGV REQRVTGIVT FLIIGLSVLA TNILGRIPMP VLYGVFLYMG ISALGGIQLF DRTLLLFMPM KYQPDTIYIR HVPIRKIHLF TAFQIGCLAL LWVIKSIKST SILFPIMLVV MVAIRKMMEK AFTTTDLKYL DDPMPDFHLR KKEDAKRRQS EGEAVEIEFD NENQATIHAV KTEAHLHIPM ASGNVIKIPL AAIQEPSHSI NLTKEVNNSG MWKHITSVDS KNSLVRDVPA SSDPTSSRDA PIEQPEDDDD PIMIKVIRPS PHTSTSNLTT ENTPLLKDEE PPKTNPDEPK V //