ID   G5EBK4_CAEEL            Unreviewed;       647 AA.
AC   G5EBK4;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   08-NOV-2023, entry version 87.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7 {ECO:0000256|ARBA:ARBA00017647, ECO:0000256|RuleBase:RU366022};
DE   AltName: Full=Autophagy-related protein 7 {ECO:0000256|RuleBase:RU366022};
GN   Name=atg-7 {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|WormBase:M7.5};
GN   ORFNames=CELE_M7.5 {ECO:0000313|EMBL:CAA92753.1}, M7.5
GN   {ECO:0000313|WormBase:M7.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92753.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like
CC       systems required for autophagy. {ECO:0000256|RuleBase:RU366022}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366022}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU366022}.
CC       Preautophagosomal structure {ECO:0000256|RuleBase:RU366022}.
CC   -!- SIMILARITY: Belongs to the ATG7 family. {ECO:0000256|ARBA:ARBA00010931,
CC       ECO:0000256|RuleBase:RU366022}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284604; CAA92753.1; -; Genomic_DNA.
DR   PIR; T23829; T23829.
DR   RefSeq; NP_502064.1; NM_069663.3.
DR   AlphaFoldDB; G5EBK4; -.
DR   SMR; G5EBK4; -.
DR   IntAct; G5EBK4; 3.
DR   STRING; 6239.M7.5; -.
DR   EPD; G5EBK4; -.
DR   PaxDb; 6239-M7-5; -.
DR   PeptideAtlas; G5EBK4; -.
DR   EnsemblMetazoa; M7.5.1; M7.5.1; WBGene00010882.
DR   GeneID; 178005; -.
DR   KEGG; cel:CELE_M7.5; -.
DR   AGR; WB:WBGene00010882; -.
DR   CTD; 178005; -.
DR   WormBase; M7.5; CE18887; WBGene00010882; atg-7.
DR   eggNOG; KOG2337; Eukaryota.
DR   GeneTree; ENSGT00390000017509; -.
DR   HOGENOM; CLU_012998_1_0_1; -.
DR   InParanoid; G5EBK4; -.
DR   OMA; RQIWDAI; -.
DR   OrthoDB; 1128973at2759; -.
DR   PhylomeDB; G5EBK4; -.
DR   Reactome; R-CEL-1632852; Macroautophagy.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010882; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0019778; F:Atg12 activating enzyme activity; IBA:GO_Central.
DR   GO; GO:0019779; F:Atg8 activating enzyme activity; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IGI:WormBase.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
DR   GO; GO:0040024; P:dauer larval development; IGI:WormBase.
DR   GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase.
DR   GO; GO:0044805; P:late nucleophagy; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; IMP:UniProtKB.
DR   GO; GO:0030163; P:protein catabolic process; IMP:WormBase.
DR   GO; GO:0032446; P:protein modification by small protein conjugation; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   CDD; cd01486; Apg7; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.140.100; Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain; 1.
DR   Gene3D; 3.40.140.70; Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain; 1.
DR   InterPro; IPR006285; Atg7.
DR   InterPro; IPR032197; Atg7_N.
DR   InterPro; IPR042522; Atg7_N_1.
DR   InterPro; IPR042523; Atg7_N_2.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   NCBIfam; TIGR01381; E1_like_apg7; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR   Pfam; PF16420; ATG7_N; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   1: Evidence at protein level;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006, ECO:0000256|RuleBase:RU366022};
KW   Cytoplasm {ECO:0000256|RuleBase:RU366022};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU366022};
KW   Proteomics identification {ECO:0007829|EPD:G5EBK4,
KW   ECO:0007829|PeptideAtlas:G5EBK4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366022};
KW   Ubl conjugation pathway {ECO:0000256|RuleBase:RU366022}.
FT   DOMAIN          4..290
FT                   /note="Ubiquitin-like modifier-activating enzyme Atg7 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16420"
FT   DOMAIN          309..571
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   ACT_SITE        523
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606285-1"
SQ   SEQUENCE   647 AA;  72371 MW;  06F54D409996D236 CRC64;
     MATFVPFVTC LDTGFWNEVN KKKLNDWKLD ETPKCISSQL SLHQTEGFKC HLSLSYDSLS
     SLESTTGLSM SGTLLLYNTI ESFKMVDKSD LIRSEAEKIW ESITTRKWLQ NPRLLSQFFI
     IAFADLKKFK YYYWTCVPAL VYPSEIKQEI TPLSSLGADH KILFDFYRKN NFPIFLYSKQ
     SSKMLELSEL ENNTNPDEIC VVVADPSPVA YSAGWMVRNV LAAVAHLHPT WKHCHIISLR
     SADSIGIKYT WTLPSAECSA DGAQNAVPKA VGWERNANDK LQPISVDLSK EFDPKILMER
     SVDLNLSLIK WRLHPDIQLE RYSQLKVLIL GAGTLGCNIA RCLIGWGVRH ISFLDNSTVS
     YNNPVRQSLS EFEDARLGRG KAETAQAAIQ RIFPSIQATA HRLTVPMPGH SIDEKDVPEL
     EKDIAKLEQL VKDHDVVFLA LDSREARWLP TVLASRHKKI AISVAIGFDT YVIIRHGIGS
     RSESVSDVSS SDSVPYSQLS CYFCSDVTAP GNSTFDRTLD QQCTVARPGT SMIASGIAVE
     LLSSVLQYPD PLKTPASHDD NTTVLGAAPH QIRGFLGRFQ QILPSVKRFD QCVACGDAIA
     AQFQQNGWKF VRDVMNSPGR LEEVTGLDEL QNSVNAIDID FEDDEDF
//