ID G5EBK4_CAEEL Unreviewed; 647 AA. AC G5EBK4; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 12-AUG-2020, entry version 75. DE RecName: Full=Ubiquitin-like modifier-activating enzyme ATG7 {ECO:0000256|RuleBase:RU366022}; DE AltName: Full=Autophagy-related protein 7 {ECO:0000256|RuleBase:RU366022}; GN Name=atg-7 {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|WormBase:M7.5}; GN ORFNames=CELE_M7.5 {ECO:0000313|EMBL:CAA92753.1}, M7.5 GN {ECO:0000313|WormBase:M7.5}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CAA92753.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA92753.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like CC systems required for autophagy. {ECO:0000256|RuleBase:RU366022}. CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366022}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU366022}. CC Preautophagosomal structure {ECO:0000256|RuleBase:RU366022}. CC -!- SIMILARITY: Belongs to the ATG7 family. {ECO:0000256|ARBA:ARBA00010931, CC ECO:0000256|RuleBase:RU366022}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284604; CAA92753.1; -; Genomic_DNA. DR PIR; T23829; T23829. DR RefSeq; NP_502064.1; NM_069663.3. DR SMR; G5EBK4; -. DR IntAct; G5EBK4; 3. DR STRING; 6239.M7.5; -. DR EPD; G5EBK4; -. DR PaxDb; G5EBK4; -. DR PeptideAtlas; G5EBK4; -. DR EnsemblMetazoa; M7.5.1; M7.5.1; WBGene00010882. DR GeneID; 178005; -. DR KEGG; cel:CELE_M7.5; -. DR CTD; 178005; -. DR WormBase; M7.5; CE18887; WBGene00010882; atg-7. DR eggNOG; KOG2337; Eukaryota. DR GeneTree; ENSGT00390000017509; -. DR HOGENOM; CLU_012998_1_0_1; -. DR InParanoid; G5EBK4; -. DR KO; K08337; -. DR OMA; PMAGHPI; -. DR OrthoDB; 549762at2759; -. DR PhylomeDB; G5EBK4; -. DR Reactome; R-CEL-1632852; Macroautophagy. DR Reactome; R-CEL-6798695; Neutrophil degranulation. DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR Proteomes; UP000001940; Chromosome IV. DR Bgee; WBGene00010882; Expressed in multi-cellular organism and 5 other tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central. DR GO; GO:0019778; F:Atg12 activating enzyme activity; IBA:GO_Central. DR GO; GO:0019779; F:Atg8 activating enzyme activity; IBA:GO_Central. DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central. DR GO; GO:0006914; P:autophagy; IGI:WormBase. DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central. DR GO; GO:0006501; P:C-terminal protein lipidation; IBA:GO_Central. DR GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central. DR GO; GO:0040024; P:dauer larval development; IGI:WormBase. DR GO; GO:0008340; P:determination of adult lifespan; IGI:WormBase. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase. DR GO; GO:0044805; P:late nucleophagy; IBA:GO_Central. DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central. DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IMP:UniProtKB. DR GO; GO:0030163; P:protein catabolic process; IMP:WormBase. DR GO; GO:0032446; P:protein modification by small protein conjugation; IBA:GO_Central. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.140.100; -; 1. DR Gene3D; 3.40.140.70; -; 1. DR InterPro; IPR006285; Atg7. DR InterPro; IPR032197; Atg7_N. DR InterPro; IPR042522; Atg7_N_1. DR InterPro; IPR042523; Atg7_N_2. DR InterPro; IPR000594; ThiF_NAD_FAD-bd. DR InterPro; IPR035985; Ubiquitin-activating_enz. DR PANTHER; PTHR10953:SF3; PTHR10953:SF3; 1. DR Pfam; PF16420; ATG7_N; 1. DR Pfam; PF00899; ThiF; 1. DR SUPFAM; SSF69572; SSF69572; 1. DR TIGRFAMs; TIGR01381; E1_like_apg7; 1. PE 1: Evidence at protein level; KW Autophagy {ECO:0000256|ARBA:ARBA00023006, ECO:0000256|RuleBase:RU366022}; KW Cytoplasm {ECO:0000256|RuleBase:RU366022}; KW Protein transport {ECO:0000256|ARBA:ARBA00022927, KW ECO:0000256|RuleBase:RU366022}; KW Proteomics identification {ECO:0000213|EPD:G5EBK4, KW ECO:0000213|PeptideAtlas:G5EBK4}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366022}; KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366022}. FT DOMAIN 4..290 FT /note="ATG7_N" FT /evidence="ECO:0000259|Pfam:PF16420" FT DOMAIN 319..592 FT /note="ThiF" FT /evidence="ECO:0000259|Pfam:PF00899" FT ACT_SITE 523 FT /note="Glycyl thioester intermediate" FT /evidence="ECO:0000256|PIRSR:PIRSR606285-1" SQ SEQUENCE 647 AA; 72371 MW; 06F54D409996D236 CRC64; MATFVPFVTC LDTGFWNEVN KKKLNDWKLD ETPKCISSQL SLHQTEGFKC HLSLSYDSLS SLESTTGLSM SGTLLLYNTI ESFKMVDKSD LIRSEAEKIW ESITTRKWLQ NPRLLSQFFI IAFADLKKFK YYYWTCVPAL VYPSEIKQEI TPLSSLGADH KILFDFYRKN NFPIFLYSKQ SSKMLELSEL ENNTNPDEIC VVVADPSPVA YSAGWMVRNV LAAVAHLHPT WKHCHIISLR SADSIGIKYT WTLPSAECSA DGAQNAVPKA VGWERNANDK LQPISVDLSK EFDPKILMER SVDLNLSLIK WRLHPDIQLE RYSQLKVLIL GAGTLGCNIA RCLIGWGVRH ISFLDNSTVS YNNPVRQSLS EFEDARLGRG KAETAQAAIQ RIFPSIQATA HRLTVPMPGH SIDEKDVPEL EKDIAKLEQL VKDHDVVFLA LDSREARWLP TVLASRHKKI AISVAIGFDT YVIIRHGIGS RSESVSDVSS SDSVPYSQLS CYFCSDVTAP GNSTFDRTLD QQCTVARPGT SMIASGIAVE LLSSVLQYPD PLKTPASHDD NTTVLGAAPH QIRGFLGRFQ QILPSVKRFD QCVACGDAIA AQFQQNGWKF VRDVMNSPGR LEEVTGLDEL QNSVNAIDID FEDDEDF //