ID G5E882_MOUSE Unreviewed; 233 AA. AC G5E882; DT 14-DEC-2011, integrated into UniProtKB/TrEMBL. DT 14-DEC-2011, sequence version 1. DT 27-NOV-2024, entry version 85. DE SubName: Full=Killer cell lectin-like receptor subfamily B member 1A {ECO:0000313|Ensembl:ENSMUSP00000032512.9}; GN Name=Klrb1a {ECO:0000313|Ensembl:ENSMUSP00000032512.9, GN ECO:0000313|MGI:MGI:107540}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000032512.9, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000032512.9, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000032512.9, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000032512.9} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000032512.9}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0007829|PDB:2MTI} RP STRUCTURE BY NMR OF 95-233, AND DISULFIDE BONDS. RX PubMed=27238500; DOI=10.1002/prot.25078; RA Rozbesky D., Adamek D., Pospisilova E., Novak P., Chmelik J.; RT "Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct RT conformation of the long loop region as compared to in the crystal RT structure."; RL Proteins 84:1304-1311(2016). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000032512.9} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000032512.9}; RG Ensembl; RL Submitted (AUG-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single- CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_034867.3; NM_010737.3. DR PDB; 2MTI; NMR; -; A=95-233. DR PDBsum; 2MTI; -. DR AlphaFoldDB; G5E882; -. DR SMR; G5E882; -. DR DNASU; 17057; -. DR Ensembl; ENSMUST00000032512.15; ENSMUSP00000032512.9; ENSMUSG00000030361.18. DR GeneID; 17057; -. DR KEGG; mmu:17057; -. DR UCSC; uc009eej.2; mouse. DR AGR; MGI:107540; -. DR CTD; 17057; -. DR MGI; MGI:107540; Klrb1a. DR VEuPathDB; HostDB:ENSMUSG00000030361; -. DR GeneTree; ENSGT00940000154685; -. DR HOGENOM; CLU_049894_8_2_1; -. DR OMA; ASNYIWK; -. DR OrthoDB; 4828219at2759; -. DR PhylomeDB; G5E882; -. DR TreeFam; TF337735; -. DR BioGRID-ORCS; 17057; 3 hits in 75 CRISPR screens. DR EvolutionaryTrace; G5E882; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030361; Expressed in epiblast cell in embryo and 22 other cell types or tissues. DR ExpressionAtlas; G5E882; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd03593; CLECT_NK_receptors_like; 1. DR FunFam; 3.10.100.10:FF:000077; Killer cell lectin-like receptor subfamily B member 1A; 1. DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR051527; KLR_subfamily_B. DR InterPro; IPR033992; NKR-like_CTLD. DR PANTHER; PTHR46784; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1; 1. DR PANTHER; PTHR46784:SF1; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1; 1. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR SUPFAM; SSF56436; C-type lectin-like; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2MTI}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Lectin {ECO:0000256|ARBA:ARBA00022734}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|ProteomicsDB:G5E882}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 51..72 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 107..217 FT /note="C-type lectin" FT /evidence="ECO:0000259|PROSITE:PS50041" FT DISULFID 100..111 FT /evidence="ECO:0007829|PDB:2MTI" FT DISULFID 128..216 FT /evidence="ECO:0007829|PDB:2MTI" FT DISULFID 195..208 FT /evidence="ECO:0007829|PDB:2MTI" SQ SEQUENCE 233 AA; 26414 MW; 19BBB56BD4B0A057 CRC64; MHLLCTMDTA RVYFGLKPPR TPGAWHESPP SLPPDACRCP RSHRLALKLS CAGLILLVVT LIGMSVLVRV LIQKPSIEKC YVLIQENLNK TTDCSAKLEC PQDWLSHRDK CFHVSQVSNT WEEGLVDCDG KGATLMLIQD QEELRFLLDS IKEKYNSFWI GLRYTLPDMN WKWINGSTLN SDVLKITGDT ENDSCAAISG DKVTFESCNS DNRWICQKEL YHETLSNYVG YGH //