ID HTR3_MAGO7 Reviewed; 126 AA. AC G4MRT1; DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot. DT 14-DEC-2011, sequence version 1. DT 29-SEP-2021, entry version 31. DE RecName: Full=Host transcription reprogramming factor 3 {ECO:0000303|PubMed:33203871}; DE AltName: Full=Secreted nuclear effector HTR3 {ECO:0000303|PubMed:33203871}; DE Flags: Precursor; GN Name=HTR3 {ECO:0000303|PubMed:33203871}; ORFNames=MGG_04580; OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast OS fungus) (Pyricularia oryzae). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia. OX NCBI_TaxID=242507; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958; RX PubMed=15846337; DOI=10.1038/nature03449; RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.; RT "The genome sequence of the rice blast fungus Magnaporthe grisea."; RL Nature 434:980-986(2005). RN [2] RP FUNCTION, AND INDUCTION. RX PubMed=33203871; DOI=10.1038/s41467-020-19624-w; RA Kim S., Kim C.Y., Park S.Y., Kim K.T., Jeon J., Chung H., Choi G., Kwon S., RA Choi J., Jeon J., Jeon J.S., Khang C.H., Kang S., Lee Y.H.; RT "Two nuclear effectors of the rice blast fungus modulate host immunity via RT transcriptional reprogramming."; RL Nat. Commun. 11:5845-5845(2020). CC -!- FUNCTION: Probable secreted effector that translocates into the nuclei CC of host cells to reprogram the expression of targeted genes by binding CC on effector binding elements in rice. {ECO:0000305|PubMed:33203871}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}. Host nucleus CC {ECO:0000305|PubMed:33203871}. CC -!- INDUCTION: Expressed during multiple stages of host plant infection, CC including the prepenetration, early biotrophy, late biotrophy, CC transition and necrotrophy. {ECO:0000269|PubMed:33203871}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM001231; EHA58296.1; -; Genomic_DNA. DR RefSeq; XP_003710908.1; XM_003710860.1. DR EnsemblFungi; MGG_04580T0; MGG_04580T0; MGG_04580. DR GeneID; 2678107; -. DR KEGG; mgr:MGG_04580; -. DR VEuPathDB; FungiDB:MGG_04580; -. DR HOGENOM; CLU_1982010_0_0_1; -. DR OrthoDB; 1643472at2759; -. DR Proteomes; UP000009058; Chromosome 1. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR InterPro; IPR013087; Znf_C2H2_type. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1. PE 2: Evidence at transcript level; KW Host nucleus; Metal-binding; Reference proteome; Secreted; Signal; KW Transcription; Transcription regulation; Virulence; Zinc; Zinc-finger. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT CHAIN 20..126 FT /note="Host transcription reprogramming factor 3" FT /id="PRO_5003465253" FT ZN_FING 79..102 FT /note="C2H2-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" SQ SEQUENCE 126 AA; 14361 MW; 2DC30C975199A1AD CRC64; MHLSTVSQIL ALFTAVASSA PTSHAAVRAR HVSPPEADLL HVVKRGDDTD FSDWQRYSLW NKRVEALSRN PELVSRYGYK CNSCGKGRMD ENGMRRHIMF DHYSKDIPLE KSAHVNKYIE FRNKGG //