ID G3X8W6_MOUSE Unreviewed; 466 AA. AC G3X8W6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 13-SEP-2023, entry version 83. DE SubName: Full=Regulator of G-protein signaling 11 {ECO:0000313|Ensembl:ENSMUSP00000025020.6}; GN Name=Rgs11 {ECO:0000313|Ensembl:ENSMUSP00000025020.6, GN ECO:0000313|MGI:MGI:1354739}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000025020.6, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000025020.6, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020.6, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000025020.6} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020.6}; RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001074538.1; NM_001081069.1. DR AlphaFoldDB; G3X8W6; -. DR SMR; G3X8W6; -. DR Antibodypedia; 22598; 154 antibodies from 27 providers. DR DNASU; 50782; -. DR Ensembl; ENSMUST00000025020.6; ENSMUSP00000025020.6; ENSMUSG00000024186.16. DR GeneID; 50782; -. DR KEGG; mmu:50782; -. DR UCSC; uc008bdr.1; mouse. DR AGR; MGI:1354739; -. DR CTD; 8786; -. DR MGI; MGI:1354739; Rgs11. DR VEuPathDB; HostDB:ENSMUSG00000024186; -. DR GeneTree; ENSGT00940000160198; -. DR OMA; WAFNFRE; -. DR OrthoDB; 22856at2759; -. DR PhylomeDB; G3X8W6; -. DR TreeFam; TF351956; -. DR BioGRID-ORCS; 50782; 1 hit in 76 CRISPR screens. DR ChiTaRS; Rgs11; mouse. DR Proteomes; UP000000589; Chromosome 17. DR Bgee; ENSMUSG00000024186; Expressed in retinal neural layer and 165 other tissues. DR ExpressionAtlas; G3X8W6; baseline and differential. DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl. DR GO; GO:0031681; F:G-protein beta-subunit binding; IEA:Ensembl. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW. DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro. DR CDD; cd04450; DEP_RGS7-like; 1. DR CDD; cd00068; GGL; 1. DR Gene3D; 1.10.1240.60; -; 1. DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1. DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR000591; DEP_dom. DR InterPro; IPR015898; G-protein_gamma-like_dom. DR InterPro; IPR036284; GGL_sf. DR InterPro; IPR016137; RGS. DR InterPro; IPR047016; RGS6/7/9/11. DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf. DR InterPro; IPR040759; RGS_DHEX. DR InterPro; IPR036305; RGS_sf. DR InterPro; IPR044926; RGS_subdomain_2. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR45746; LP21163P; 1. DR PANTHER; PTHR45746:SF3; REGULATOR OF G-PROTEIN SIGNALING 11; 1. DR Pfam; PF00610; DEP; 1. DR Pfam; PF00631; G-gamma; 1. DR Pfam; PF00615; RGS; 1. DR Pfam; PF18148; RGS_DHEX; 1. DR PRINTS; PR01301; RGSPROTEIN. DR SMART; SM00049; DEP; 1. DR SMART; SM01224; G_gamma; 1. DR SMART; SM00224; GGL; 1. DR SMART; SM00315; RGS; 1. DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1. DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS50186; DEP; 1. DR PROSITE; PS50132; RGS; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}. FT DOMAIN 34..109 FT /note="DEP" FT /evidence="ECO:0000259|PROSITE:PS50186" FT DOMAIN 303..418 FT /note="RGS" FT /evidence="ECO:0000259|PROSITE:PS50132" FT REGION 441..466 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 442..456 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 466 AA; 53643 MW; 99675728D6EBA09C CRC64; MAMVTRCTPH GGCSRMQRPH LSKMERVVVS MQDPDQGVKM RSQRLLITVI PHAVAGRDLV EWLVQKFCIL EDEALHLGTL LAQHGYIYPL RESRDLTLRP DETPYRFQTP YFWTSTMWPA AELDYAIYLA KKNIQKQGAL VDYEKEHYAL LHKKINHAWD LVLMQAREQL RAAKQRRKGD RMVISCQEQT YWLVNKPPPG APNILEQGPE RGSYNPSHMQ MSSDFYKCEI ECFRKALGRN RVKSSACLEA YLKFSSQHGP HDPIMSGCLP SNPWITDDVT YWAMNAPNVA APTKLRVERW SFSFRELLDD PVGRAHFMDF LQKEFSAENL SFWEACEELR FGGQAQVPTL VDSVYQQFLA PGAARWINID SRTMERTLEG LRQPHRYVLD AAQLHIYMLM KKDSYPRFLK SDIYKGLLEE AVIPLETKRW PFPFLRKPLH SSPSPALQST PREPAATSSP EGADGE //