ID G3X8W6_MOUSE Unreviewed; 466 AA. AC G3X8W6; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 26-NOV-2014, entry version 26. DE SubName: Full=MCG1588, isoform CRA_c {ECO:0000313|EMBL:EDL22497.1}; DE SubName: Full=Regulator of G-protein-signaling 11 {ECO:0000313|Ensembl:ENSMUSP00000025020}; GN Name=Rgs11 {ECO:0000313|Ensembl:ENSMUSP00000025020, GN ECO:0000313|MGI:MGI:1354739}; GN ORFNames=mCG_1588 {ECO:0000313|EMBL:EDL22497.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000025020, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|EMBL:EDL22497.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL22497.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDL22497.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL22497.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000025020, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000025020} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- SIMILARITY: Contains 1 RGS domain. CC {ECO:0000256|RuleBase:RU003298}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC126438; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH466606; EDL22497.1; -; Genomic_DNA. DR RefSeq; NP_001074538.1; NM_001081069.1. DR UniGene; Mm.109840; -. DR Ensembl; ENSMUST00000025020; ENSMUSP00000025020; ENSMUSG00000024186. DR GeneID; 50782; -. DR KEGG; mmu:50782; -. DR UCSC; uc008bdr.1; mouse. DR CTD; 8786; -. DR MGI; MGI:1354739; Rgs11. DR GeneTree; ENSGT00760000119142; -. DR KO; K16449; -. DR OMA; MQDPDMG; -. DR TreeFam; TF351956; -. DR ChiTaRS; Rgs11; mouse. DR NextBio; 307737; -. DR GO; GO:0005737; C:cytoplasm; IBA:RefGenome. DR GO; GO:0044292; C:dendrite terminus; IDA:MGI. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IBA:RefGenome. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GOC. DR GO; GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. DR Gene3D; 1.10.10.10; -; 1. DR Gene3D; 1.10.196.10; -; 1. DR Gene3D; 4.10.260.10; -; 1. DR InterPro; IPR000591; DEP_dom. DR InterPro; IPR015898; G-protein_gamma-like_dom. DR InterPro; IPR024066; Regulat_G_prot_signal_dom1. DR InterPro; IPR016137; Regulat_G_prot_signal_superfam. DR InterPro; IPR000342; RGS_dom. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF00610; DEP; 1. DR Pfam; PF00631; G-gamma; 1. DR Pfam; PF00615; RGS; 1. DR PRINTS; PR01301; RGSPROTEIN. DR SMART; SM00049; DEP; 1. DR SMART; SM00224; GGL; 1. DR SMART; SM00315; RGS; 1. DR SUPFAM; SSF48097; SSF48097; 1. DR SUPFAM; SSF48670; SSF48670; 1. DR PROSITE; PS50186; DEP; 1. DR PROSITE; PS50132; RGS; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 466 AA; 53643 MW; 99675728D6EBA09C CRC64; MAMVTRCTPH GGCSRMQRPH LSKMERVVVS MQDPDQGVKM RSQRLLITVI PHAVAGRDLV EWLVQKFCIL EDEALHLGTL LAQHGYIYPL RESRDLTLRP DETPYRFQTP YFWTSTMWPA AELDYAIYLA KKNIQKQGAL VDYEKEHYAL LHKKINHAWD LVLMQAREQL RAAKQRRKGD RMVISCQEQT YWLVNKPPPG APNILEQGPE RGSYNPSHMQ MSSDFYKCEI ECFRKALGRN RVKSSACLEA YLKFSSQHGP HDPIMSGCLP SNPWITDDVT YWAMNAPNVA APTKLRVERW SFSFRELLDD PVGRAHFMDF LQKEFSAENL SFWEACEELR FGGQAQVPTL VDSVYQQFLA PGAARWINID SRTMERTLEG LRQPHRYVLD AAQLHIYMLM KKDSYPRFLK SDIYKGLLEE AVIPLETKRW PFPFLRKPLH SSPSPALQST PREPAATSSP EGADGE //