ID G3MTY7_CAEEL Unreviewed; 711 AA. AC G3MTY7; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 07-OCT-2020, entry version 75. DE SubName: Full=TRP_2 domain-containing protein {ECO:0000313|EMBL:CCD31094.1}; GN Name=spe-41 {ECO:0000313|EMBL:CCD31094.1, GN ECO:0000313|WormBase:K01A11.4b}; GN ORFNames=CELE_K01A11.4 {ECO:0000313|EMBL:CCD31094.1}, K01A11.4 GN {ECO:0000313|WormBase:K01A11.4b}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD31094.1, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD31094.1, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD31094.1, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology."; RL Science 282:2012-2018(1998). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284603; CCD31094.1; -; Genomic_DNA. DR RefSeq; NP_001254873.1; NM_001267944.1. DR EnsemblMetazoa; K01A11.4b.1; K01A11.4b.1; WBGene00004976. DR GeneID; 175446; -. DR CTD; 175446; -. DR WormBase; K01A11.4b; CE46278; WBGene00004976; spe-41. DR GeneTree; ENSGT00990000203600; -. DR HOGENOM; CLU_023138_0_0_1; -. DR Proteomes; UP000001940; Chromosome III. DR Bgee; WBGene00004976; Expressed in material anatomical entity and 4 other tissues. DR ExpressionAtlas; G3MTY7; baseline and differential. DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:WormBase. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase. DR GO; GO:0031260; C:pseudopodium membrane; IDA:WormBase. DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central. DR GO; GO:0015279; F:store-operated calcium channel activity; IDA:WormBase. DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0006816; P:calcium ion transport; IDA:WormBase. DR GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:WormBase. DR GO; GO:0006828; P:manganese ion transport; IBA:GO_Central. DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR GO; GO:0007338; P:single fertilization; IMP:WormBase. DR InterPro; IPR013555; TRP_dom. DR InterPro; IPR002153; TRPC_channel. DR PANTHER; PTHR10117; PTHR10117; 1. DR Pfam; PF08344; TRP_2; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..18 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 19..711 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003447489" FT TRANSMEM 184..203 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 224..244 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 289..310 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 330..353 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 374..395 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 428..446 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 466..488 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 508..534 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 34..88 FT /note="TRP_2" FT /evidence="ECO:0000259|Pfam:PF08344" FT REGION 651..697 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 683..697 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 711 AA; 80958 MW; BEACD74448919507 CRC64; MTPLMLACIL NNFSIVQCLI TRGHCIQIPH FITCECKTCK RETVTTHSST RLVDVMRALS SEAYLWLATD DVFAATCAVA RDLQQLASDD QLEYVETYRD LEMNVQRFLC RISDQAWRVD EFNMMVANRN YCPERMTEIS SPRLQMAMDS QMRQFTCSTN SQTTIKSVFR SDWYNYGIKP KRDAWRFLRA CILMPFLVML HAFMPTKGTT MCVPLARFIA HITMYLVFLI AAILRPTIGF YFAWTDSIEV TVQALEIFMY AYVMGLALEK GILFYRVGRD GFFAFWWRWF DAALIFIFLF SLIFFTGKWG KREAFDPSSV DRMHWPSFEF SLLHEICLAI ACVLSILKCF YYAQMMKSIG GSVISVGKCV GKTYTYILIM VAIIVSFSVG LNIIVDPYLN RSTMKIGDQD YTKTTDSYET IGTSSKNLFW SIFGYLGPST FTTVVGNTGP NMDPVKHTLN SSTFEILAAV YHGILIITVL NLMTSILVKG ADEVLDNEEM EFKFTRAAIY SEFLSWEMAA PPPLNLILVV AHFVHRNLLK RYYASPAWGE KPANDDVEDQ AADEQYMQLL MVVFARFVAS KECKYKSIWR SEFHREEKQP PRVTFLTTGA HSFLMDNTFE GFKMRSSRTM EAEGYKEYTT VQYYVPKSKT PGPAAAADAG TKVAPKDDKP QNNPVLARTG IDSPVPSSKQ VMSSELSASI PRARDVTFLG V //