ID G3FA37_9HIV1 Unreviewed; 345 AA. AC G3FA37; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 25-JAN-2012, entry version 3. DE SubName: Full=Pol protein; DE Flags: Fragment; GN Name=pol; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=K1; RA Zeng P.; RT "The human immunodeficiency virus-1 genotype diversity and profile of RT drug resistance mutations among volunteer blood donors in China."; RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = CC diphosphate + DNA(n+1). CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family. CC -!- SIMILARITY: Contains 1 peptidase A2 domain. CC -!- SIMILARITY: Contains 1 reverse transcriptase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF505552; AEN55660.1; -; Genomic_DNA. DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro. DR InterPro; IPR018061; Pept_A2A_retrovirus_sg. DR InterPro; IPR001995; Peptidase_A2_cat. DR InterPro; IPR021109; Peptidase_aspartic. DR InterPro; IPR001969; Peptidase_aspartic_AS. DR InterPro; IPR009007; Peptidase_aspartic_catalytic. DR InterPro; IPR000477; RVT. DR Gene3D; G3DSA:2.40.70.10; Pept_Aspartc_cat; 1. DR Pfam; PF00077; RVP; 1. DR Pfam; PF00078; RVT_1; 1. DR SUPFAM; SSF50630; Pept_Aspartic; 1. DR PROSITE; PS50175; ASP_PROT_RETROV; 1. DR PROSITE; PS00141; ASP_PROTEASE; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Aspartyl protease; Hydrolase; Multifunctional enzyme; KW Nucleotidyltransferase; Protease; RNA-directed DNA polymerase; KW Transferase. FT NON_TER 1 1 FT NON_TER 345 345 SQ SEQUENCE 345 AA; 39394 MW; 6582C6249A086881 CRC64; SFPQITLWQR PLVTIKIGGQ MKEALLDTGA DDTVLEDINL PGKWKPKMIG GIGGFIKVRQ YDQILIEICG KKAIGTVLVG PTPVNIIGRN MLTQLGCTLN FPISPIDTVP VTLKPGMDGP RVKQWPLTEE KIKALTEICK EMEEEGKISR IGPENPYNTP VFAIKKKDST KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG LKKKKSVTVL DVGDAYFSVP LDESFRKYTA FTIPSINNET PGIRYQYNVL PQGWKGSPAI FQCSMTKILE PFRKKNPEMV IYQYMDDLYV GSDLEIGQHR TKIEELRDHL LSWGFTTPDK KHQKEPPFLW MGYELHPDRW TVQPI //