ID G2WBX3_YEASK Unreviewed; 375 AA. AC G2WBX3; DT 16-NOV-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 1. DT 10-FEB-2021, entry version 33. DE RecName: Full=Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyldiphosphate specific) {ECO:0000256|ARBA:ARBA00012596}; DE EC=2.5.1.87 {ECO:0000256|ARBA:ARBA00012596}; GN Name=K7_NUS1 {ECO:0000313|EMBL:GAA22059.1}; GN ORFNames=SYK7_009331 {ECO:0000313|EMBL:GAA22059.1}; OS Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's OS yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=721032 {ECO:0000313|EMBL:GAA22059.1, ECO:0000313|Proteomes:UP000001608}; RN [1] {ECO:0000313|EMBL:GAA22059.1, ECO:0000313|Proteomes:UP000001608} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Kyokai no. 7 / NBRC 101557 {ECO:0000313|Proteomes:UP000001608}; RX PubMed=21900213; DOI=10.1093/dnares/dsr029; RA Akao T., Yashiro I., Hosoyama A., Kitagaki H., Horikawa H., Watanabe D., RA Akada R., Ando Y., Harashima S., Inoue T., Inoue Y., Kajiwara S., RA Kitamoto K., Kitamoto N., Kobayashi O., Kuhara S., Masubuchi T., RA Mizoguchi H., Nakao Y., Nakazato A., Namise M., Oba T., Ogata T., Ohta A., RA Sato M., Shibasaki S., Takatsume Y., Tanimoto S., Tsuboi H., Nishimura A., RA Yoda K., Ishikawa T., Iwashita K., Fujita N., Shimoi H.; RT "Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no. RT 7."; RL DNA Res. 18:423-434(2011). CC -!- CATALYTIC ACTIVITY: CC Reaction=(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di- CC trans,poly-cis-polyprenyl diphosphate + n diphosphate; CC Xref=Rhea:RHEA:53008, Rhea:RHEA-COMP:13431, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:128769, ChEBI:CHEBI:136960, ChEBI:CHEBI:175763; CC EC=2.5.1.87; Evidence={ECO:0000256|ARBA:ARBA00000976}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- PATHWAY: Protein modification; protein glycosylation. CC {ECO:0000256|ARBA:ARBA00004922}. CC -!- SIMILARITY: Belongs to the UPP synthase family. CC {ECO:0000256|ARBA:ARBA00005432}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DG000040; GAA22059.1; -; Genomic_DNA. DR EnsemblFungi; GAA22059; GAA22059; SYK7_009331. DR HOGENOM; CLU_051870_0_0_1; -. DR UniPathway; UPA00378; -. DR Proteomes; UP000001608; Chromosome IV. DR GO; GO:1904423; C:dehydrodolichyl diphosphate synthase complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro. DR GO; GO:0019408; P:dolichol biosynthetic process; IEA:InterPro. DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway. DR Gene3D; 3.40.1180.10; -; 1. DR InterPro; IPR038887; Nus1/NgBR. DR InterPro; IPR036424; UPP_synth-like_sf. DR PANTHER; PTHR21528; PTHR21528; 1. DR SUPFAM; SSF64005; SSF64005; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 98..117 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 1..48 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..32 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 375 AA; 42565 MW; 476EE1744CF680F8 CRC64; MPTMIKKDDK AMEPPNEKPH RKIERDDVPE SSNHIPPPES GVLKGGKVNS KTRALKAVTS IIADADENPQ KKVSNETNGV QKQKTEDLSK RIGKFEYLFY KFLLVLLYIC FGLFRYGQYQ YHKMKLRIFS IIYNHAYTPQ LIRQDVIPLK KIPKRLAAIL EVKPVGDVGG GVTGLLNDAS EIVCWTVSAG IKHLMLYDYD GILQRNVPEL RMEIHSNLAK YFGPAHVPNY AVKIPHSNKI FYNLDGIETE IDVGNEIEAN QEKDKIAIEI SLLSNRDGRE TIVDLTKTMA ELCAVNELSV SDITMDLVDS ELKQLVGPEP DLLLYFGPSL DLQGFPPWHI RLTEFYWEKD NNEVIYSVFI RGLRQYAGCK VNVGK //