ID G1SS70_RABIT Unreviewed; 264 AA. AC G1SS70; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 29-APR-2015, entry version 35. DE RecName: Full=40S ribosomal protein S3a {ECO:0000256|HAMAP-Rule:MF_03122}; GN Name=LOC100357498 {ECO:0000313|Ensembl:ENSOCUP00000006063}; GN Synonyms=LOC100354966 {ECO:0000313|Ensembl:ENSOCUP00000022874}, RPS3A GN {ECO:0000256|HAMAP-Rule:MF_03122, GN ECO:0000313|Ensembl:ENSOCUP00000024017}; OS Oryctolagus cuniculus (Rabbit). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; OC Oryctolagus. OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006063, ECO:0000313|Proteomes:UP000001811}; RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006063, ECO:0000313|Proteomes:UP000001811} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006063, RC ECO:0000313|Proteomes:UP000001811}; RX PubMed=21993624; DOI=10.1038/nature10530; RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., RA Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., RA Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., RA Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S., RA Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., RA Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., RA Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., RA Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., RA Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., RA Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., RA Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., RA Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., RA Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., RA Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., RA Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., RA Pedersen J.S., Lander E.S., Kellis M.; RT "A high-resolution map of human evolutionary constraint using 29 RT mammals."; RL Nature 478:476-482(2011). RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006063} RP IDENTIFICATION. RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006063}; RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. RN [3] {ECO:0000213|PDB:4D5L} RP STRUCTURE BY ELECTRON MICROSCOPY (9.00 ANGSTROMS). RX PubMed=25601755; RA Muhs M., Hilal T., Mielke T., Skabkin M.A., Sanbonmatsu K.Y., RA Pestova T.V., Spahn C.M.; RT "Cryo-EM of Ribosomal 80S Complexes with Termination Factors Reveals RT the Translocated Cricket Paralysis Virus IRES."; RL Mol. Cell 57:422-432(2015). CC -!- FUNCTION: May play a role during erythropoiesis through regulation CC of transcription factor DDIT3. {ECO:0000256|HAMAP-Rule:MF_03122}. CC -!- SUBUNIT: Component of the small ribosomal subunit. Mature CC ribosomes consist of a small (40S) and a large (60S) subunit. The CC 40S subunit contains about 33 different proteins and 1 molecule of CC RNA (18S). The 60S subunit contains about 49 different proteins CC and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a CC IGF2BP1-dependent mRNP granule complex containing untranslated CC mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3. CC {ECO:0000256|HAMAP-Rule:MF_03122}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03122}. CC Nucleus {ECO:0000256|HAMAP-Rule:MF_03122}. Note=Localized in CC cytoplasmic mRNP granules containing untranslated mRNAs. CC {ECO:0000256|HAMAP-Rule:MF_03122}. CC -!- SIMILARITY: Belongs to the ribosomal protein S3Ae family. CC {ECO:0000256|HAMAP-Rule:MF_03122, ECO:0000256|RuleBase:RU000668}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000006063}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAGW02045887; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAGW02046150; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AAGW02060912; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_002711475.1; XM_002711429.2. DR RefSeq; XP_002716948.1; XM_002716902.2. DR RefSeq; XP_002720434.1; XM_002720388.2. DR PDB; 4D5L; EM; 9.00 A; B=1-264. DR PDBsum; 4D5L; -. DR ProteinModelPortal; G1SS70; -. DR SMR; G1SS70; 19-233. DR PRIDE; G1SS70; -. DR Ensembl; ENSOCUT00000007010; ENSOCUP00000006063; ENSOCUG00000007011. DR Ensembl; ENSOCUT00000024660; ENSOCUP00000024017; ENSOCUG00000022751. DR Ensembl; ENSOCUT00000026147; ENSOCUP00000022874; ENSOCUG00000023695. DR GeneID; 100342838; -. DR GeneID; 100348981; -. DR GeneID; 100354966; -. DR KEGG; ocu:100342838; -. DR KEGG; ocu:100348981; -. DR KEGG; ocu:100354966; -. DR CTD; 6189; -. DR GeneTree; ENSGT00390000018433; -. DR InParanoid; G1SS70; -. DR KO; K02984; -. DR OMA; GQNAYTK; -. DR OrthoDB; EOG7Q5HDW; -. DR TreeFam; TF300037; -. DR Proteomes; UP000001811; Chromosome 15. DR Proteomes; UP000001811; Chromosome 4. DR Proteomes; UP000001811; Chromosome X. DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:UniProtKB-HAMAP. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:UniProtKB-HAMAP. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0006412; P:translation; IEA:UniProtKB-HAMAP. DR HAMAP; MF_03122; Ribosomal_S3Ae_euk; 1. DR InterPro; IPR027500; Ribosomal_S1/3_euk. DR InterPro; IPR001593; Ribosomal_S3Ae. DR InterPro; IPR018281; Ribosomal_S3Ae_CS. DR Pfam; PF01015; Ribosomal_S3Ae; 1. DR PROSITE; PS01191; RIBOSOMAL_S3AE; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:4D5L}; KW Complete proteome {ECO:0000313|Proteomes:UP000001811}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03122, KW ECO:0000256|SAAS:SAAS00003726}; KW Differentiation {ECO:0000256|HAMAP-Rule:MF_03122}; KW Nucleus {ECO:0000256|HAMAP-Rule:MF_03122}; KW Reference proteome {ECO:0000313|Proteomes:UP000001811}; KW Ribonucleoprotein {ECO:0000256|HAMAP-Rule:MF_03122, KW ECO:0000256|RuleBase:RU000668}; KW Ribosomal protein {ECO:0000256|HAMAP-Rule:MF_03122, KW ECO:0000256|RuleBase:RU000668}. FT INIT_MET 1 1 Removed. {ECO:0000256|HAMAP-Rule: FT MF_03122}. SQ SEQUENCE 264 AA; 29945 MW; 000037AE195F7A9D CRC64; MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITED VQGKNCLTNF HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI RKTSYAQHQQ VRQIRKKMME IMTREVQTND LKEVVNKLIP DSIGKDIEKA CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHGEGSSSGK ATGDETGAKV ERADGYEPPV QESV //