ID G1N9K2_MELGA Unreviewed; 1403 AA. AC G1N9K2; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 16-NOV-2011, sequence version 2. DT 12-APR-2017, entry version 48. DE RecName: Full=Cystic fibrosis transmembrane conductance regulator {ECO:0000256|RuleBase:RU362037}; DE EC=3.6.3.49 {ECO:0000256|RuleBase:RU362037}; DE AltName: Full=ATP-binding cassette sub-family C member 7 {ECO:0000256|RuleBase:RU362037}; DE AltName: Full=Channel conductance-controlling ATPase {ECO:0000256|RuleBase:RU362037}; DE AltName: Full=cAMP-dependent chloride channel {ECO:0000256|RuleBase:RU362037}; GN Name=CFTR {ECO:0000313|Ensembl:ENSMGAP00000009096}; OS Meleagris gallopavo (Common turkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Meleagridinae; Meleagris. OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000009096, ECO:0000313|Proteomes:UP000001645}; RN [1] {ECO:0000313|Ensembl:ENSMGAP00000009096, ECO:0000313|Proteomes:UP000001645} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475; RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A., RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K., RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C., RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A., RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., RA de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., RA Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P., RA Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S., RA Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M., RA Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S., RA Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F., RA Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P., RA Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.; RT "Multi-platform next-generation sequencing of the domestic turkey RT (Meleagris gallopavo): genome assembly and analysis."; RL PLoS Biol. 8:E1000475-E1000475(2010). RN [2] {ECO:0000313|Ensembl:ENSMGAP00000009096} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2011) to UniProtKB. CC -!- FUNCTION: Involved in the transport of chloride ions. CC {ECO:0000256|RuleBase:RU362037}. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. CC {ECO:0000256|RuleBase:RU362037}. CC -!- SUBCELLULAR LOCATION: Early endosome membrane CC {ECO:0000256|RuleBase:RU362037}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU362037}. CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC CC family. CFTR transporter (TC 3.A.1.202) subfamily. CC {ECO:0000256|RuleBase:RU362037}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000009096}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 9103.ENSMGAP00000009096; -. DR Ensembl; ENSMGAT00000009910; ENSMGAP00000009096; ENSMGAG00000008826. DR eggNOG; KOG0054; Eukaryota. DR eggNOG; COG1132; LUCA. DR GeneTree; ENSGT00860000133687; -. DR InParanoid; G1N9K2; -. DR OMA; NALRRCF; -. DR OrthoDB; EOG091G00K4; -. DR TreeFam; TF105200; -. DR Proteomes; UP000001645; Chromosome 1. DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0031205; C:endoplasmic reticulum Sec complex; IEA:Ensembl. DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl. DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:Ensembl. DR GO; GO:0019869; F:chloride channel inhibitor activity; IEA:Ensembl. DR GO; GO:0005260; F:intracellular ATPase-gated chloride channel activity; IEA:UniProtKB-EC. DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl. DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Ensembl. DR GO; GO:0030301; P:cholesterol transport; IEA:Ensembl. DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl. DR GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl. DR GO; GO:1902161; P:positive regulation of cyclic nucleotide-gated ion channel activity; IEA:Ensembl. DR GO; GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl. DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl. DR GO; GO:1902943; P:positive regulation of voltage-gated chloride channel activity; IEA:Ensembl. DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl. DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:Ensembl. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR009147; CFTR/ABCC7. DR InterPro; IPR025837; CFTR_reg_dom. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR24223:SF273; PTHR24223:SF273; 1. DR Pfam; PF00664; ABC_membrane; 2. DR Pfam; PF00005; ABC_tran; 2. DR Pfam; PF14396; CFTR_R; 1. DR PRINTS; PR01851; CYSFIBREGLTR. DR SMART; SM00382; AAA; 2. DR SUPFAM; SSF52540; SSF52540; 2. DR SUPFAM; SSF90123; SSF90123; 2. DR TIGRFAMs; TIGR01271; CFTR_protein; 1. DR PROSITE; PS50929; ABC_TM1F; 2. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|RuleBase:RU362037}; KW Chloride {ECO:0000256|RuleBase:RU362037}; KW Chloride channel {ECO:0000256|RuleBase:RU362037}; KW Complete proteome {ECO:0000313|Proteomes:UP000001645}; KW Hydrolase {ECO:0000256|RuleBase:RU362037}; KW Ion channel {ECO:0000256|RuleBase:RU362037}; KW Ion transport {ECO:0000256|RuleBase:RU362037}; KW Membrane {ECO:0000256|RuleBase:RU362037}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|RuleBase:RU362037}; KW Phosphoprotein {ECO:0000256|RuleBase:RU362037}; KW Reference proteome {ECO:0000313|Proteomes:UP000001645}; KW Repeat {ECO:0000256|SAAS:SAAS00761389}; KW Transmembrane {ECO:0000256|RuleBase:RU362037}; KW Transmembrane helix {ECO:0000256|RuleBase:RU362037}; KW Transport {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 59 78 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 106 124 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 182 203 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 209 228 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 291 314 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 849 874 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 906 925 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 945 964 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 976 998 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 1004 1023 Helical. {ECO:0000256|RuleBase:RU362037}. FT TRANSMEM 1095 1113 Helical. {ECO:0000256|RuleBase:RU362037}. FT DOMAIN 73 310 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT DOMAIN 410 633 ABC transporter. {ECO:0000259|PROSITE: FT PS50893}. FT DOMAIN 850 1145 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT DOMAIN 1198 1403 ABC transporter. {ECO:0000259|PROSITE: FT PS50893}. FT NP_BIND 445 452 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00434}. FT NP_BIND 1232 1239 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00434}. SQ SEQUENCE 1403 AA; 158740 MW; 29C3D4D883E3FD0D CRC64; FFFRWTKPIL KKGYRQRLEL SDIYQIPSAD SADNLSEKLE REWDRELATS KKKPKLINAL RRCFFWKFMF YGILLYLGEV TKSVQPLLLG RIIASYDPDN FSERSIAYYL GIGLCLLFLV RTLLIHPSIF GLHHIGMQIR IALFSLIYKK TLKLSSKVLD KISTGQLVSL LSNNLNKFDE GLALAHFVWI APLQVALLMG LLWDMLQASA FAGLAFLIVM AFFQAWLGQM MMKYRDRRAG KINERLVITS EIIENIQSVK AYCWEDAMEK MIESLRETEL KLTRKAAYVR YFNSSAFFFS GFFVVFLAVV PYAVTKGIIL RKIFTTISFC IVLRMTVTRQ FPGSVQTWYD SIGAINKIQD FLLKEEYKAL EYNLTTTGVE VDKVTAFWDE GIGELFVKAK QENNNSKAPS NDNNLFFSNF PLHASPVLQD INFKIEKGEL LAVSGSTGSG KTSLLMLIMG ELEPSQGKIK HSGRISFSPQ VSWIMPGTIK ENIIFGVSYD EYRYKSVIQA CQLEEDILKF PDKDYTVLGE GGIILSGGQR ARISLARAVY KDADLYLMDS PFGYLDIFTE KEIFESCVCK LMANKTRILV TSKLEHLKIA DKILILHEGS CYFYGTFSEL QGQRPDFSSE LMGFDSFDQF SAERRNSIIT ETLRRFSFEG ESMGSRNEIK KQSFKQTSDF NDKRKNSIII NPLNAGRKLS IMQKNGTQVN GLEDGHVDPS ERRISLVPDL EQGDVGLPRS NMLNSDHMLQ SRRRQSVLSL MTGTSVNQGP HVSKKGSTTF RKMSMVPQTN LSSEIDIYTR RLSRDSILDI TDEINEDDLK ECFTDDAESM GTVTTWNTYF RYITIHKSLI FVLILCVIIF LLEVAASLVL LLFLQKAAKI NETQPENATS DSPPVIITDT SSYYMIYIYV GIADTLLAMG IFRGLPLVHT LITVSKTLHQ KMVHAVLYAP MSAFNSLKAG GILNRFSKDT AILDDLLPLT VFDLIQLILI VIGAITVVSI LQPYIFLASV PVIAAFIVLR AYFLHTSQQL KQLESEARSP IFTHLVTSLK GLWTLRAFGR QPYFETLFHK ALNLHTANWF LYLSTLRWFQ MRIEMIFVVF FSAVAFISII TTGDGPGRVG IILTLAMNIM GTLQWAVNSS IDVDSLMRSV SRIFKFIDMP TEEMKTIKPQ KNNQFSDALV IENRHVKDEK NWPSGGQMTV TDLTARYTEG GTAVLENISF SISSGQTVGL LGRTGSGKST LLFAFLRLLN TEGDIRIDGI SWNTVSLQQW RKAFGVIPQK VFIFSGTFRK NLDPYGQWND EEIWKVAEEV GLKSVIEQFP GQLDFVLVDG GCVLSHGHKQ LMCLARSVLS KAKILLLDEP SAHLDPITSQ VIRKTLKHAF ADCTVILSEH RLEAILECQR FLV //