ID G1EJ78_9HIV1 Unreviewed; 327 AA. AC G1EJ78; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 11-DEC-2019, entry version 28. DE SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:AEJ88814.1}; DE Flags: Fragment; GN Name=env {ECO:0000313|EMBL:AEJ88814.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEJ88814.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AEJ88814.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1468F2B9_MW_C_02 {ECO:0000313|EMBL:AEJ88814.1}; RX PubMed=21593171; DOI=10.1128/JVI.00197-11; RA Russell E.S., Kwiek J.J., Keys J., Barton K., Mwapasa V., Montefiori D.C., RA Meshnick S.R., Swanstrom R.; RT "The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not RT Driven by Selection of Especially Neutralization-Resistant Virus from the RT Maternal Viral Population."; RL J. Virol. 85:8253-8262(2011). RN [2] {ECO:0000313|EMBL:AEJ88814.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1468F2B9_MW_C_02 {ECO:0000313|EMBL:AEJ88814.1}; RA Russell E., Kwiek J., Keys J., Barton K., Mwapasa V., Montefiori D., RA Meshnick S., Swanstrom R.; RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000256|SAAS:SAAS01050327}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN108071; AEJ88814.1; -; Genomic_RNA. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 1. DR InterPro; IPR036377; Gp120_core_sf. DR InterPro; IPR000777; HIV1_Gp120. DR Pfam; PF00516; GP120; 1. DR SUPFAM; SSF56502; SSF56502; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|SAAS:SAAS01050261}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS01050351}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01050329}; KW Membrane {ECO:0000256|SAAS:SAAS01050265}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS01050352}; KW Viral envelope protein {ECO:0000313|EMBL:AEJ88814.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS01050355}; KW Virion {ECO:0000256|SAAS:SAAS01050315}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS01050293}. FT DOMAIN 14..323 FT /note="GP120" FT /evidence="ECO:0000259|Pfam:PF00516" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AEJ88814.1" FT NON_TER 327 FT /evidence="ECO:0000313|EMBL:AEJ88814.1" SQ SEQUENCE 327 AA; 36214 MW; F59CD4D7BC038B48 CRC64; CTNVNSTYNN INITGEIKNC TFNTTTELKD KKRTEYALFY KLDVVPLTNE TTSHYRLINC NTSTIAQACP KVSFDPIPIH YCAPAGYAIL KCNNKTFNGT GPCNNVSTVQ CTHGIKPVVS TQLLLNGSLA EEEIIIRSEN LTDNVKTIIV QLKDPVEIMC TRPNNNTRKS IRIGPGQTFY GTDIIGDIRQ AHCNITKSNW TKTLNKVGEK LRKHFNKTIS FKPSSGGDLE ITTHSFNCGG EFFYCNTSNL FNSTYNGTTH DSADNSNITL QCRIKQIINM WQEVGRAMYA PPIAGNITCK SNITGLLLTR DGGNSNGTNE TEIFRPG //