ID   G0S1R5_CHATD            Unreviewed;       634 AA.
AC   G0S1R5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   12-OCT-2022, entry version 39.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 17 {ECO:0000256|ARBA:ARBA00019610, ECO:0000256|RuleBase:RU364140};
DE   AltName: Full=Mediator complex subunit 17 {ECO:0000256|ARBA:ARBA00032014, ECO:0000256|RuleBase:RU364140};
GN   Name=MED17 {ECO:0000256|RuleBase:RU364140};
GN   ORFNames=CTHT_0014540 {ECO:0000313|EMBL:EGS22975.1};
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS   (Thermochaetoides thermophila).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX   NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN   [1] {ECO:0000313|EMBL:EGS22975.1, ECO:0000313|Proteomes:UP000008066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC   {ECO:0000313|Proteomes:UP000008066};
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
RN   [2] {ECO:0007829|PDB:6XP5}
RP   STRUCTURE BY ELECTRON MICROSCOPY (4.20 ANGSTROMS).
RX   PubMed=33571424; DOI=10.1016/j.molcel.2021.01.022;
RA   Zhang H., Chen D.H., Mattoo R.U.H., Bushnell D.A., Wang Y., Yuan C.,
RA   Wang L., Wang C., Davis R.E., Nie Y., Kornberg R.D.;
RT   "Mediator structure and conformation change.";
RL   Mol. Cell 81:1781-1788.e4(2021).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364140}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364140}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364140}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family.
CC       {ECO:0000256|ARBA:ARBA00005635, ECO:0000256|RuleBase:RU364140}.
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DR   EMBL; GL988039; EGS22975.1; -; Genomic_DNA.
DR   RefSeq; XP_006691967.1; XM_006691904.1.
DR   PDB; 6XP5; EM; 4.20 A; Q=1-634.
DR   SMR; G0S1R5; -.
DR   STRING; 759272.G0S1R5; -.
DR   EnsemblFungi; EGS22975; EGS22975; CTHT_0014540.
DR   GeneID; 18255492; -.
DR   KEGG; cthr:CTHT_0014540; -.
DR   eggNOG; ENOG502QS9H; Eukaryota.
DR   HOGENOM; CLU_015164_0_0_1; -.
DR   OrthoDB; 900096at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019313; Mediator_Med17.
DR   PANTHER; PTHR13114; PTHR13114; 1.
DR   Pfam; PF10156; Med17; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6XP5};
KW   Activator {ECO:0000256|RuleBase:RU364140};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364140};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364140}.
FT   REGION          44..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   634 AA;  69538 MW;  BE4500A8B5D80E76 CRC64;
     MTDRPFILQV PPTQQRGPQN IAEFVARINP DAFRVLNEAE LRRKVEEEKN GVGQDEDVDM
     ESSPSDNEGE PADAKDIITA KHEMLRVIDQ TRQTTLYALD FVSLLLSKEN PGQAVTTFSP
     GLRELVGIGT LGATMLDAPT PLTQSRIPDN KLVTIGKRLM DLNKAADTAL AASKRLQKEI
     AAETKYWSEV LAVRNDGWQT SRMPREPQTM GVKFGFNNAA PEFKAVSIAP MRRADNGSVL
     LDRSSIGHKS QRIQVRILED GRIVGRSSLP SPVSADAPLQ DRVKEMRDTI FAQELWHEIN
     REARTLLNQG VHLEPSSITY TMDASTTVSI RLATLGEEEE GLDEQQEGPQ DVMAESLNIA
     LSLLLSHAHR MNELRRSEPG INKGPPRTYP ILLPLISYHK YNQSIQTCLQ TLSAHISVLR
     SASVDSSMTV KEPLLSSPPG APAATSLYTI LTRPPAVQFD ITITPDSRIR ILLKPTQLTG
     AAFSICCLPA LHPGAQNPLA TTCPPSTDDY DSLTQVVSYL QAAIPRALAA HYEAVLVVEA
     TVNGGMLGDL PPSPSRWMPL IDGKGIVDPE TMRFGIRFSF GRNPAKGGQL ELGAQTDYVD
     GSRKRVRRNW IWPGAQSSLD SVAKHVLARG PPEE
//