ID G0S1R5_CHATD Unreviewed; 634 AA. AC G0S1R5; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 07-NOV-2018, entry version 26. DE RecName: Full=Mediator of RNA polymerase II transcription subunit 17 {ECO:0000256|RuleBase:RU364140}; DE AltName: Full=Mediator complex subunit 17 {ECO:0000256|RuleBase:RU364140}; GN Name=MED17 {ECO:0000256|RuleBase:RU364140}; GN ORFNames=CTHT_0014540 {ECO:0000313|EMBL:EGS22975.1}; OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae; OC Chaetomium. OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066}; RN [1] {ECO:0000313|EMBL:EGS22975.1, ECO:0000313|Proteomes:UP000008066} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719 RC {ECO:0000313|Proteomes:UP000008066}; RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039; RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., RA Devos D.P., Arumugam M., Bork P., Hurt E.; RT "Insight into structure and assembly of the nuclear pore complex by RT utilizing the genome of a eukaryotic thermophile."; RL Cell 146:277-289(2011). CC -!- FUNCTION: Component of the Mediator complex, a coactivator CC involved in the regulated transcription of nearly all RNA CC polymerase II-dependent genes. Mediator functions as a bridge to CC convey information from gene-specific regulatory proteins to the CC basal RNA polymerase II transcription machinery. Mediator is CC recruited to promoters by direct interactions with regulatory CC proteins and serves as a scaffold for the assembly of a functional CC preinitiation complex with RNA polymerase II and the general CC transcription factors. {ECO:0000256|RuleBase:RU364140}. CC -!- SUBUNIT: Component of the Mediator complex. CC {ECO:0000256|RuleBase:RU364140}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364140}. CC -!- SIMILARITY: Belongs to the Mediator complex subunit 17 family. CC {ECO:0000256|RuleBase:RU364140}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL988039; EGS22975.1; -; Genomic_DNA. DR RefSeq; XP_006691967.1; XM_006691904.1. DR EnsemblFungi; EGS22975; EGS22975; CTHT_0014540. DR GeneID; 18255492; -. DR KEGG; cthr:CTHT_0014540; -. DR KO; K15134; -. DR OrthoDB; EOG092C3XD1; -. DR Proteomes; UP000008066; Unassembled WGS sequence. DR GO; GO:0016592; C:mediator complex; IEA:InterPro. DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro. DR InterPro; IPR019313; Mediator_Med17. DR PANTHER; PTHR13114; PTHR13114; 1. DR Pfam; PF10156; Med17; 1. PE 3: Inferred from homology; KW Activator {ECO:0000256|RuleBase:RU364140}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008066}; KW Nucleus {ECO:0000256|RuleBase:RU364140}; KW Reference proteome {ECO:0000313|Proteomes:UP000008066}; KW Transcription {ECO:0000256|RuleBase:RU364140}; KW Transcription regulation {ECO:0000256|RuleBase:RU364140}. FT COILED 159 179 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 634 AA; 69538 MW; BE4500A8B5D80E76 CRC64; MTDRPFILQV PPTQQRGPQN IAEFVARINP DAFRVLNEAE LRRKVEEEKN GVGQDEDVDM ESSPSDNEGE PADAKDIITA KHEMLRVIDQ TRQTTLYALD FVSLLLSKEN PGQAVTTFSP GLRELVGIGT LGATMLDAPT PLTQSRIPDN KLVTIGKRLM DLNKAADTAL AASKRLQKEI AAETKYWSEV LAVRNDGWQT SRMPREPQTM GVKFGFNNAA PEFKAVSIAP MRRADNGSVL LDRSSIGHKS QRIQVRILED GRIVGRSSLP SPVSADAPLQ DRVKEMRDTI FAQELWHEIN REARTLLNQG VHLEPSSITY TMDASTTVSI RLATLGEEEE GLDEQQEGPQ DVMAESLNIA LSLLLSHAHR MNELRRSEPG INKGPPRTYP ILLPLISYHK YNQSIQTCLQ TLSAHISVLR SASVDSSMTV KEPLLSSPPG APAATSLYTI LTRPPAVQFD ITITPDSRIR ILLKPTQLTG AAFSICCLPA LHPGAQNPLA TTCPPSTDDY DSLTQVVSYL QAAIPRALAA HYEAVLVVEA TVNGGMLGDL PPSPSRWMPL IDGKGIVDPE TMRFGIRFSF GRNPAKGGQL ELGAQTDYVD GSRKRVRRNW IWPGAQSSLD SVAKHVLARG PPEE //