ID G0RTP3_HYPJQ Unreviewed; 514 AA. AC G0RTP3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 08-NOV-2023, entry version 67. DE RecName: Full=Transcriptional adapter 2 {ECO:0000256|PIRNR:PIRNR025024}; GN Name=ada2 {ECO:0000313|EMBL:EGR45469.1}; GN ORFNames=TRIREDRAFT_123619 {ECO:0000313|EMBL:EGR45469.1}; OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma. OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984}; RN [1] {ECO:0000313|EMBL:EGR45469.1, ECO:0000313|Proteomes:UP000008984} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=QM6a {ECO:0000313|EMBL:EGR45469.1, RC ECO:0000313|Proteomes:UP000008984}; RX PubMed=18454138; DOI=10.1038/nbt1403; RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E., RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G., RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I., RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B., RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N., RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A., RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S., RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.; RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma RT reesei (syn. Hypocrea jecorina)."; RL Nat. Biotechnol. 26:553-560(2008). CC -!- FUNCTION: Functions as component of the transcription regulatory CC histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is CC involved in RNA polymerase II-dependent transcriptional regulation. CC {ECO:0000256|PIRNR:PIRNR025024}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR025024}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL985079; EGR45469.1; -; Genomic_DNA. DR RefSeq; XP_006968656.1; XM_006968594.1. DR AlphaFoldDB; G0RTP3; -. DR STRING; 51453.EGR45469; -. DR EnsemblFungi; EGR45469; EGR45469; TRIREDRAFT_123619. DR GeneID; 18483683; -. DR KEGG; tre:TRIREDRAFT_123619; -. DR VEuPathDB; FungiDB:TRIREDRAFT_123619; -. DR eggNOG; KOG0457; Eukaryota. DR HOGENOM; CLU_018273_1_0_1; -. DR OrthoDB; 206414at2759; -. DR Proteomes; UP000008984; Unassembled WGS sequence. DR GO; GO:0140671; C:ADA complex; IEA:EnsemblFungi. DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0000124; C:SAGA complex; IEA:EnsemblFungi. DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:EnsemblFungi. DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi. DR GO; GO:0001786; F:phosphatidylserine binding; IEA:EnsemblFungi. DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0071470; P:cellular response to osmotic stress; IEA:EnsemblFungi. DR GO; GO:0000183; P:rDNA heterochromatin formation; IEA:EnsemblFungi. DR GO; GO:0035065; P:regulation of histone acetylation; IEA:InterPro. DR GO; GO:0010520; P:regulation of reciprocal meiotic recombination; IEA:EnsemblFungi. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi. DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IEA:EnsemblFungi. DR GO; GO:0031509; P:subtelomeric heterochromatin formation; IEA:EnsemblFungi. DR CDD; cd02335; ZZ_ADA2; 1. DR Gene3D; 3.30.60.90; -; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR041983; ADA2-like_ZZ. DR InterPro; IPR016827; Ada2/TADA2. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR InterPro; IPR007526; SWIRM. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR000433; Znf_ZZ. DR InterPro; IPR043145; Znf_ZZ_sf. DR PANTHER; PTHR12374:SF20; TRANSCRIPTIONAL ADAPTER 2-ALPHA; 1. DR PANTHER; PTHR12374; TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED; 1. DR Pfam; PF00249; Myb_DNA-binding; 1. DR Pfam; PF04433; SWIRM; 1. DR Pfam; PF00569; ZZ; 1. DR PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1. DR SMART; SM00717; SANT; 1. DR SMART; SM00291; ZnF_ZZ; 1. DR SUPFAM; SSF46689; Homeodomain-like; 2. DR SUPFAM; SSF57850; RING/U-box; 1. DR PROSITE; PS50090; MYB_LIKE; 1. DR PROSITE; PS51293; SANT; 1. DR PROSITE; PS50934; SWIRM; 1. DR PROSITE; PS01357; ZF_ZZ_1; 1. DR PROSITE; PS50135; ZF_ZZ_2; 1. PE 4: Predicted; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR025024}; KW Reference proteome {ECO:0000313|Proteomes:UP000008984}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, KW ECO:0000256|PIRNR:PIRNR025024}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|PIRNR:PIRNR025024}; Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00228}. FT DOMAIN 16..75 FT /note="ZZ-type" FT /evidence="ECO:0000259|PROSITE:PS50135" FT DOMAIN 77..130 FT /note="SANT" FT /evidence="ECO:0000259|PROSITE:PS51293" FT DOMAIN 82..126 FT /note="Myb-like" FT /evidence="ECO:0000259|PROSITE:PS50090" FT DOMAIN 426..514 FT /note="SWIRM" FT /evidence="ECO:0000259|PROSITE:PS50934" FT REGION 161..189 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 348..379 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 392..423 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 514 AA; 57955 MW; 0A9CB165AF37AA38 CRC64; MGVIRKKTAT RGGEGGVKYV CDVCSCDITS TVRIRCADPA CSDFDLCVPC FGKGESRNAH DPATHAFRVI EQNSFPIFDR EWGADEELLL LEGAEIYGLG SWADIADHIG GFREKDEVRD HYLKTYIESP NFPLPERCSP HNNELANEIP REEFQARKKR RIEERREASK NAPALQPKTK PTASVPSCHE IQGYMPGRLE FETEYANEAE EAVQLMQFDP GDGINPKTGE LEPEMELKLT VMEIYNCRLT QRVERKKVIF EHNLLDYREN TKQEKRKTKE ERDLLQRAKP FARIMNHKDF EDFTQGLQDE LNLRQAIAQL QEWRSMKIGD LRSGEKYEAE KAARIQKAIP MGSMDRERLA SSQRSKAQPP PEPPSGASLL VAPELPIRSA QANGEANGED GKALTNGQAN GVNGHSPAKQ KYVPQPISGV PPLQLTQENA PDYHLLTPEE AKLCEVLRLQ PKPYLMIKEQ IIKEAIKGNG TLKKKQAKEI CRLDSQKGAR LFDFFSNAGW VGKA //