ID G0RTP3_HYPJQ Unreviewed; 514 AA. AC G0RTP3; DT 19-OCT-2011, integrated into UniProtKB/TrEMBL. DT 19-OCT-2011, sequence version 1. DT 10-APR-2019, entry version 48. DE RecName: Full=Transcriptional adapter 2 {ECO:0000256|PIRNR:PIRNR025024}; GN Name=ada2 {ECO:0000313|EMBL:EGR45469.1}; GN ORFNames=TRIREDRAFT_123619 {ECO:0000313|EMBL:EGR45469.1}; OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae; OC Trichoderma. OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984}; RN [1] {ECO:0000313|EMBL:EGR45469.1, ECO:0000313|Proteomes:UP000008984} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=QM6a {ECO:0000313|EMBL:EGR45469.1, RC ECO:0000313|Proteomes:UP000008984}; RX PubMed=18454138; DOI=10.1038/nbt1403; RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., RA Baker S.E., Chapman J., Chertkov O., Coutinho P.M., Cullen D., RA Danchin E.G., Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., RA Han C.S., Ho I., Larrondo L.F., de Leon A.L., Magnuson J.K., RA Merino S., Misra M., Nelson B., Putnam N., Robbertse B., Salamov A.A., RA Schmoll M., Terry A., Thayer N., Westerholm-Parvinen A., Schoch C.L., RA Yao J., Barabote R., Nelson M.A., Detter C., Bruce D., Kuske C.R., RA Xie G., Richardson P., Rokhsar D.S., Lucas S.M., Rubin E.M., RA Dunn-Coleman N., Ward M., Brettin T.S.; RT "Genome sequencing and analysis of the biomass-degrading fungus RT Trichoderma reesei (syn. Hypocrea jecorina)."; RL Nat. Biotechnol. 26:553-560(2008). CC -!- FUNCTION: Functions as component of the transcription regulatory CC histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is CC involved in RNA polymerase II-dependent transcriptional CC regulation. {ECO:0000256|PIRNR:PIRNR025024}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR025024, CC ECO:0000256|SAAS:SAAS00548613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL985079; EGR45469.1; -; Genomic_DNA. DR RefSeq; XP_006968656.1; XM_006968594.1. DR ProteinModelPortal; G0RTP3; -. DR STRING; 51453.EGR45469; -. DR EnsemblFungi; EGR45469; EGR45469; TRIREDRAFT_123619. DR GeneID; 18483683; -. DR KEGG; tre:TRIREDRAFT_123619; -. DR EuPathDB; FungiDB:TRIREDRAFT_123619; -. DR KO; K11314; -. DR Proteomes; UP000008984; Unassembled WGS sequence. DR GO; GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IEA:EnsemblFungi. DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC. DR GO; GO:0000124; C:SAGA complex; IEA:EnsemblFungi. DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:EnsemblFungi. DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi. DR GO; GO:0001786; F:phosphatidylserine binding; IEA:EnsemblFungi. DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0000183; P:chromatin silencing at rDNA; IEA:EnsemblFungi. DR GO; GO:0006348; P:chromatin silencing at telomere; IEA:EnsemblFungi. DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi. DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IEA:EnsemblFungi. DR InterPro; IPR016827; Ada2/TADA2. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR InterPro; IPR007526; SWIRM. DR InterPro; IPR000433; Znf_ZZ. DR Pfam; PF00249; Myb_DNA-binding; 1. DR Pfam; PF04433; SWIRM; 1. DR Pfam; PF00569; ZZ; 1. DR PIRSF; PIRSF025024; Transcriptional_adaptor_2; 1. DR SMART; SM00717; SANT; 1. DR SMART; SM00291; ZnF_ZZ; 1. DR SUPFAM; SSF46689; SSF46689; 2. DR PROSITE; PS51293; SANT; 1. DR PROSITE; PS50934; SWIRM; 1. DR PROSITE; PS01357; ZF_ZZ_1; 1. DR PROSITE; PS50135; ZF_ZZ_2; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000008984}; KW Metal-binding {ECO:0000256|SAAS:SAAS00594504}; KW Nucleus {ECO:0000256|PIRNR:PIRNR025024, KW ECO:0000256|SAAS:SAAS00501360}; KW Reference proteome {ECO:0000313|Proteomes:UP000008984}; KW Transcription {ECO:0000256|PIRNR:PIRNR025024}; KW Transcription regulation {ECO:0000256|PIRNR:PIRNR025024}; KW Zinc {ECO:0000256|SAAS:SAAS00594632}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00228, KW ECO:0000256|SAAS:SAAS00594509}. FT DOMAIN 21 64 ZZ-type. {ECO:0000259|PROSITE:PS50135}. FT DOMAIN 77 130 SANT. {ECO:0000259|PROSITE:PS51293}. FT DOMAIN 426 514 SWIRM. {ECO:0000259|PROSITE:PS50934}. FT COILED 268 288 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 514 AA; 57955 MW; 0A9CB165AF37AA38 CRC64; MGVIRKKTAT RGGEGGVKYV CDVCSCDITS TVRIRCADPA CSDFDLCVPC FGKGESRNAH DPATHAFRVI EQNSFPIFDR EWGADEELLL LEGAEIYGLG SWADIADHIG GFREKDEVRD HYLKTYIESP NFPLPERCSP HNNELANEIP REEFQARKKR RIEERREASK NAPALQPKTK PTASVPSCHE IQGYMPGRLE FETEYANEAE EAVQLMQFDP GDGINPKTGE LEPEMELKLT VMEIYNCRLT QRVERKKVIF EHNLLDYREN TKQEKRKTKE ERDLLQRAKP FARIMNHKDF EDFTQGLQDE LNLRQAIAQL QEWRSMKIGD LRSGEKYEAE KAARIQKAIP MGSMDRERLA SSQRSKAQPP PEPPSGASLL VAPELPIRSA QANGEANGED GKALTNGQAN GVNGHSPAKQ KYVPQPISGV PPLQLTQENA PDYHLLTPEE AKLCEVLRLQ PKPYLMIKEQ IIKEAIKGNG TLKKKQAKEI CRLDSQKGAR LFDFFSNAGW VGKA //