ID F8WBA1_HUMAN Unreviewed; 482 AA. AC F8WBA1; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 13-SEP-2023, entry version 81. DE SubName: Full=Butyrophilin like 2 {ECO:0000313|Ensembl:ENSP00000390613.3}; DE SubName: Full=Butyrophilin-like protein 2 {ECO:0000313|Ensembl:ENSP00000399884.2}; GN Name=BTNL2 {ECO:0000313|Ensembl:ENSP00000390613.3}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390613.3, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390613.3, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000390613.3} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL662796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL670296; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL935032; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR752644; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753634; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759917; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU019529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001291490.1; NM_001304561.1. DR RefSeq; XP_016866546.1; XM_017011057.1. DR ProteomicsDB; 30738; -. DR Antibodypedia; 50239; 160 antibodies from 19 providers. DR DNASU; 56244; -. DR Ensembl; ENST00000416597.5; ENSP00000415396.2; ENSG00000224770.7. DR Ensembl; ENST00000422056.5; ENSP00000416544.2; ENSG00000229597.7. DR Ensembl; ENST00000445928.5; ENSP00000399884.2; ENSG00000226127.7. DR Ensembl; ENST00000447918.5; ENSP00000414811.2; ENSG00000229741.7. DR Ensembl; ENST00000454136.8; ENSP00000390613.3; ENSG00000204290.11. DR GeneID; 56244; -. DR KEGG; hsa:56244; -. DR MANE-Select; ENST00000454136.8; ENSP00000390613.3; NM_001304561.2; NP_001291490.1. DR UCSC; uc063nqv.1; human. DR CTD; 56244; -. DR HGNC; HGNC:1142; BTNL2. DR VEuPathDB; HostDB:ENSG00000204290; -. DR GeneTree; ENSGT00940000162484; -. DR OMA; GEMQLMC; -. DR OrthoDB; 2943983at2759; -. DR BioGRID-ORCS; 56244; 1 hit in 243 CRISPR screens. DR GenomeRNAi; 56244; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204290; Expressed in sural nerve and 83 other tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl. DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl. DR CDD; cd05713; IgV_MOG_like; 2. DR Gene3D; 2.60.40.10; Immunoglobulins; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR24100:SF105; BTNL2-RELATED; 1. DR PANTHER; PTHR24100; BUTYROPHILIN; 1. DR Pfam; PF07686; V-set; 2. DR SMART; SM00409; IG; 3. DR SMART; SM00407; IGc1; 1. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF48726; Immunoglobulin; 4. DR PROSITE; PS50835; IG_LIKE; 3. PE 4: Predicted; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 459..477 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 43..140 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 156..234 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT DOMAIN 236..355 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 482 AA; 53517 MW; 0AF4BC1960F43198 CRC64; MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC QLLPKRTTMH VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN GIAKGNVALK IHNIQPSDNG QYWCHFQDGN YCGETSLLLK VAGLGSAPSI HMEGPGESGV QLVCTARGWF PEPQVYWEDI RGEKLLAVSE HRIQDKDGLF YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ TELASLKVNG PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ EASLDLKVVS LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK TIPSSSQALT QGSHGLFHVQ TLLRVTNISA VDVTCSISIP FLGEEKIATF SLSESRMTFL WKTLLVWGLL LAVAVGLPRK RS //