ID F8WBA1_HUMAN Unreviewed; 482 AA. AC F8WBA1; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 05-JUN-2019, entry version 60. DE SubName: Full=Butyrophilin-like protein 2 {ECO:0000313|Ensembl:ENSP00000390613}; GN Name=BTNL2 {ECO:0000313|Ensembl:ENSP00000390613}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390613, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390613, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000390613} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000399884} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL662796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL670296; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL935032; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR752644; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753634; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759917; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU019529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001291490.1; NM_001304561.1. DR RefSeq; XP_016866546.1; XM_017011057.1. DR PRIDE; F8WBA1; -. DR Ensembl; ENST00000416597; ENSP00000415396; ENSG00000224770. DR Ensembl; ENST00000422056; ENSP00000416544; ENSG00000229597. DR Ensembl; ENST00000445928; ENSP00000399884; ENSG00000226127. DR Ensembl; ENST00000447918; ENSP00000414811; ENSG00000229741. DR Ensembl; ENST00000454136; ENSP00000390613; ENSG00000204290. DR GeneID; 56244; -. DR KEGG; hsa:56244; -. DR UCSC; uc063nqv.1; human. DR CTD; 56244; -. DR HGNC; HGNC:1142; BTNL2. DR OpenTargets; ENSG00000204290; -. DR eggNOG; ENOG410IJJG; Eukaryota. DR eggNOG; ENOG410YIB9; LUCA. DR GeneTree; ENSGT00940000162484; -. DR OMA; VQWRDME; -. DR OrthoDB; 522383at2759; -. DR GenomeRNAi; 56244; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000204290; Expressed in 66 organ(s), highest expression level in amygdala. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl. DR GO; GO:1900042; P:positive regulation of interleukin-2 secretion; IEA:Ensembl. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 4. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR Pfam; PF07686; V-set; 2. DR SMART; SM00409; IG; 3. DR SMART; SM00407; IGc1; 1. DR SMART; SM00406; IGv; 2. DR SUPFAM; SSF48726; SSF48726; 4. DR PROSITE; PS50835; IG_LIKE; 3. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 459 477 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 43 140 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 156 234 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 236 355 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 482 AA; 53517 MW; 0AF4BC1960F43198 CRC64; MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC QLLPKRTTMH VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN GIAKGNVALK IHNIQPSDNG QYWCHFQDGN YCGETSLLLK VAGLGSAPSI HMEGPGESGV QLVCTARGWF PEPQVYWEDI RGEKLLAVSE HRIQDKDGLF YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ TELASLKVNG PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ EASLDLKVVS LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK TIPSSSQALT QGSHGLFHVQ TLLRVTNISA VDVTCSISIP FLGEEKIATF SLSESRMTFL WKTLLVWGLL LAVAVGLPRK RS //