ID F8W8R6_HUMAN Unreviewed; 1384 AA. AC F8W8R6; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 17-JUN-2020, entry version 77. DE SubName: Full=Lysine-specific demethylase 6A {ECO:0000313|Ensembl:ENSP00000372355}; GN Name=KDM6A {ECO:0000313|Ensembl:ENSP00000372355}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372355, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000372355, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [2] {ECO:0000213|PubMed:19413330} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [4] {ECO:0000313|Ensembl:ENSP00000372355} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [5] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC136488; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL133545; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL138744; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510678; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; F8W8R6; -. DR PeptideAtlas; F8W8R6; -. DR PRIDE; F8W8R6; -. DR ProteomicsDB; 30193; -. DR Antibodypedia; 639; 190 antibodies. DR Ensembl; ENST00000382899; ENSP00000372355; ENSG00000147050. DR UCSC; uc064yru.1; human. DR EuPathDB; HostDB:ENSG00000147050.14; -. DR HGNC; HGNC:12637; KDM6A. DR OpenTargets; ENSG00000147050; -. DR eggNOG; KOG1124; Eukaryota. DR eggNOG; KOG1246; Eukaryota. DR eggNOG; COG0457; LUCA. DR GeneTree; ENSGT00940000155202; -. DR ChiTaRS; KDM6A; human. DR Proteomes; UP000005640; Chromosome X. DR Bgee; ENSG00000147050; Expressed in kidney and 222 other tissues. DR ExpressionAtlas; F8W8R6; baseline and differential. DR Gene3D; 1.25.40.10; -; 2. DR InterPro; IPR003347; JmjC_dom. DR InterPro; IPR013026; TPR-contain_dom. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR Pfam; PF02373; JmjC; 1. DR Pfam; PF13181; TPR_8; 1. DR SMART; SM00558; JmjC; 1. DR SMART; SM00028; TPR; 6. DR SUPFAM; SSF48452; SSF48452; 2. DR PROSITE; PS51184; JMJC; 1. DR PROSITE; PS50005; TPR; 7. DR PROSITE; PS50293; TPR_REGION; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0000213|EPD:F8W8R6, KW ECO:0000213|MaxQB:F8W8R6, ECO:0000213|PeptideAtlas:F8W8R6, KW ECO:0000213|ProteomicsDB:F8W8R6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}. FT DOMAIN 69..361 FT /note="TPR_REGION" FT /evidence="ECO:0000259|PROSITE:PS50293" FT REPEAT 69..102 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 106..139 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 181..214 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 226..259 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 260..293 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 294..327 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 328..361 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT DOMAIN 1078..1241 FT /note="JmjC" FT /evidence="ECO:0000259|PROSITE:PS51184" FT REGION 406..447 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 607..729 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 741..761 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 793..847 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 897..923 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1026..1062 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 793..845 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 900..920 FT /note="Pro-rich" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1029..1059 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1384 AA; 152619 MW; F51EC414F6398CDC CRC64; MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC YLNATRSKSC SNTSALAARI KYLQACKPHH PNTEPVLGLS QTPISQQSLP LHMIPSSQVD DLSSPAKRKR TSSPTKNTSD NWSGGHAVSH PPVQQQAHSW CLTPQKLQHL EQLRANRNNL NPAQKLMLEQ LESQFVLMQQ HQMRPTGVAQ VRSTGIPNGP TADSSLPTNS VSGQQPQLAL TRVPSVSQPG VRPACPGQPL ANGPFSAGHV PCSTSRTLGS TDTILIGNNH ITGSGSNGNV PYLQRNALTL PHNRTNLTSS AEEPWKNQLS NSTQGLHKGQ SSHSAGPNGE RPLSSTGPSQ HLQAAGSGIQ NQNGHPTLPS NSVTQGAALN HLSSHTATSG GQQGITLTKE SKPSGNILTV PETSRHTGET PNSTASVEGL PNHVHQMTAD AVCSPSHGDS KSPGLLSSDN PQLSALLMGK ANNNVGTGTC DKVNNIHPAV HTKTDNSVAS SPSSAISTAT PSPKSTEQTT TNSVTSLNSP HSGLHTINGE GMEESQSPMK TDLLLVNHKP SPQIIPSMSV SIYPSSAEVL KACRNLGKNG LSNSSILLDK CPPPRPPSSP YPPLPKDKLN PPTPSIYLEN KRDAFFPPLH QFCTNPNNPV TVIRGLAGAL KLDLGLFSTK TLVEANNEHM VEVRTQLLQP ADENWDPTGT KKIWHCESNR SHTTIAKYAQ YQASSFQESL REENEKRSHH KDHSDSESTS SDNSGRRRKG PFKTIKFGTN IDLSDDKKWK LQLHELTKLP AFVRVVSAGN LLSHVGHTIL GMNTVQLYMK VPGSRTPGHQ ENNNFCSVNI NIGPGDCEWF VVPEGYWGVL NDFCEKNNLN FLMGSWWPNL EDLYEANVPV YRFIQRPGDL VWINAGTVHW VQAIGWCNNI AWNVGPLTAC QYKLAVERYE WNKLQSVKSI VPMVHLSWNM ARNIKVSDPK LFEMIKYCLL RTLKQCQTLR EALIAAGKEI IWHGRTKEEP AHYCSICEVE VFDLLFVTNE SNSRKTYIVH CQDCARKTSG NLENFVVLEQ YKMEDLMQVY DQFTLAPPLP SASS //