ID F8SXI4_9SCIU Unreviewed; 423 AA. AC F8SXI4; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 15-FEB-2017, entry version 24. DE SubName: Full=RAG1 protein {ECO:0000313|EMBL:AEI73032.1}; DE Flags: Fragment; GN Name=RAG1 {ECO:0000313|EMBL:AEI73032.1}; OS Tamiops maritimus (maritime striped squirrel). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Sciuridae; Callosciurinae; Callosciurini; Tamiops. OX NCBI_TaxID=1048687 {ECO:0000313|EMBL:AEI73032.1}; RN [1] {ECO:0000313|EMBL:AEI73032.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TW3 {ECO:0000313|EMBL:AEI73032.1}; RA Chang S.-W., Oshida T., Endo H., Nguyen S.T., Dang C.N., Nguyen D.X., RA Jiang X., Li Z.-J., Lin L.-K.; RT "Ancient hybridization and underestimated species diversity in Asian RT striped squirrels (genus Tamiops): inference from paternal, maternal RT and biparental markers."; RL J. Zool. (Lond.) 285:128-138(2011). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- DOMAIN: The NBD (nonamer binding) DNA-binding domain mediates the CC specific binding to the nonamer RSS motif by forming a tightly CC interwoven homodimer that binds and synapses 2 nonamer elements, CC with each NBD making contact with both DNA molecules. Each RSS is CC composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and CC nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a CC spacer of either 12 bp or 23 bp. {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- SIMILARITY: Belongs to the RAG1 family. {ECO:0000256|PROSITE- CC ProRule:PRU00820}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00820}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ698449; AEI73032.1; -; Genomic_DNA. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0033151; P:V(D)J recombination; IEA:InterPro. DR Gene3D; 3.30.160.60; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR024627; RAG1. DR InterPro; IPR019485; RAG1_Znf. DR InterPro; IPR023336; RAG_nonamer-bd_dom. DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR PANTHER; PTHR11539; PTHR11539; 1. DR Pfam; PF12940; RAG1; 1. DR Pfam; PF10426; zf-RAG1; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS51487; NBD; 1. DR PROSITE; PS51765; ZF_RAG1; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 3: Inferred from homology; KW DNA recombination {ECO:0000256|PROSITE-ProRule:PRU00820}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00820}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00820}. FT DOMAIN 260 299 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 321 350 RAG1-type. {ECO:0000259|PROSITE:PS51765}. FT DOMAIN 359 423 NBD (nonamer binding) DNA-binding. FT {ECO:0000259|PROSITE:PS51487}. FT NON_TER 1 1 {ECO:0000313|EMBL:AEI73032.1}. FT NON_TER 423 423 {ECO:0000313|EMBL:AEI73032.1}. SQ SEQUENCE 423 AA; 48575 MW; 798329AA2A2360B8 CRC64; RVRSLEKTTE ETQKEKKDSS EEKPPLEQSP AVLDKSGGQK PVLTQPALKG HPKFSKKFHD GGKARDKAIH QANLRHFCRI CGNSFKTDEH NRRYPVHGPV DAKTQVLLRK KEKRVTSWPD LIARVFRIDV RADVDAIHPT EFCHNCWNIM HRKFSSAPCE VYFPRNATME WHPHTPSCDI CHFARRGLKR KRHQPNVQLS KKLKTVLDQA RQARQCKRRA QARISSKEVM KKITNCSKIH LGTNLLAVDF PAXFVKSISC QICEHILADP VETSCKHVFC RICILRCLKV MGSYCPSCRY PCFPTDLESP VKSFLSILNS LVVKCPAKEC NEEVSLEKYN HHVSSHKESK ETFVHINKGG RPRQHLLSLT RRAQKHRLRE LKLQVKAFAD KEEGGDVKSV CLTLFLLALR ARNEHRQANE LEA //