ID F8PQY2_SERL3 Unreviewed; 449 AA. AC F8PQY2; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 27-NOV-2024, entry version 41. DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147}; DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356}; GN ORFNames=SERLA73DRAFT_177056 {ECO:0000313|EMBL:EGO01639.1}; OS Serpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus). OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; OC Agaricomycetidae; Boletales; Coniophorineae; Serpulaceae; Serpula. OX NCBI_TaxID=936435 {ECO:0000313|Proteomes:UP000008063}; RN [1] {ECO:0000313|Proteomes:UP000008063} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=strain S7.3 {ECO:0000313|Proteomes:UP000008063}; RX PubMed=21764756; DOI=10.1126/science.1205411; RA Eastwood D.C., Floudas D., Binder M., Majcherczyk A., Schneider P., RA Aerts A., Asiegbu F.O., Baker S.E., Barry K., Bendiksby M., Blumentritt M., RA Coutinho P.M., Cullen D., de Vries R.P., Gathman A., Goodell B., RA Henrissat B., Ihrmark K., Kauserud H., Kohler A., LaButti K., Lapidus A., RA Lavin J.L., Lee Y.-H., Lindquist E., Lilly W., Lucas S., Morin E., RA Murat C., Oguiza J.A., Park J., Pisabarro A.G., Riley R., Rosling A., RA Salamov A., Schmidt O., Schmutz J., Skrede I., Stenlid J., Wiebenga A., RA Xie X., Kuees U., Hibbett D.S., Hoffmeister D., Hoegberg N., Martin F., RA Grigoriev I.V., Watkinson S.C.; RT "The plant cell wall-decomposing machinery underlies the functional RT diversity of forest fungi."; RL Science 333:762-765(2011). CC -!- SUBUNIT: Component of the translation initiation factor 2B (eIF2B) CC complex which is a heterodecamer of two sets of five different CC subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta CC and delta comprise a regulatory subcomplex and subunits epsilon and CC gamma comprise a catalytic subcomplex. Within the complex, the CC hexameric regulatory complex resides at the center, with the two CC heterodimeric catalytic subcomplexes bound on opposite sides. CC {ECO:0000256|ARBA:ARBA00046432}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol CC {ECO:0000256|ARBA:ARBA00004514}. CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family. CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL945477; EGO01639.1; -; Genomic_DNA. DR AlphaFoldDB; F8PQY2; -. DR STRING; 936435.F8PQY2; -. DR eggNOG; KOG1467; Eukaryota. DR HOGENOM; CLU_016218_3_1_1; -. DR InParanoid; F8PQY2; -. DR OMA; MRDYVIC; -. DR OrthoDB; 169924at2759; -. DR Proteomes; UP000008063; Unassembled WGS sequence. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR InterPro; IPR000649; IF-2B-related. DR InterPro; IPR042529; IF_2B-like_C. DR InterPro; IPR037171; NagB/RpiA_transferase-like. DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1. DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1. DR Pfam; PF01008; IF-2B; 1. DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Initiation factor {ECO:0000256|ARBA:ARBA00022540}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}; KW Reference proteome {ECO:0000313|Proteomes:UP000008063}. FT REGION 1..88 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..25 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 26..41 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 449 AA; 47881 MW; 4AD78C6A0C3B0089 CRC64; MKSVFQNVTV NGEASGSQQP PKSQKTMTKA ERRELQEKQR AAKAVSKTPG APGGAANAKG GAKPSVPAPS TPTAKKVRRG TDAAMTKPAG AGKDVLSIVG EDTARGLRIF SHFGLPKPPG QAKGDIHPTI VRLGLQFSEF KISGANARCI ATLTAFKTVI QDYVTPPNNT LSRHLMTHLS PQITYLVSAR PMSVTMGNAI RQLKLEISGS DIDLPEQDAK DALCRKIDNY IRDRIIIADQ VIQETAGKKI KDGNVIMTYA RSSVVEKVLL RAHAEGKQFS VIVVDSRPML EGKKLLAVLS SVGIPCTYLL LPAVGSIITE VSIVLVGAHS LHSNGAVFSR AGTALVAMMA KQHSVPVVVC CETYKFSDNV QLDSFIKNEL APEGDLFSSF PLTRPKNTLT LHGQANLEIL NPLYDLTPPT SITAVVTEVG VIPPSSISSI PLALGRTTI //