ID F8JX84_STREN Unreviewed; 909 AA. AC F8JX84; G8X2B4; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 16-JAN-2019, entry version 46. DE SubName: Full=Putative penicillin acylase {ECO:0000313|EMBL:AEW94549.1}; GN OrderedLocusNames=SCATT_21780 {ECO:0000313|EMBL:AEW94549.1}; OS Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC OS 14057 / NRRL 8057). OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; OC Streptomyces. OX NCBI_TaxID=1003195 {ECO:0000313|EMBL:AEW94549.1, ECO:0000313|Proteomes:UP000007842}; RN [1] {ECO:0000313|Proteomes:UP000007842} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057 RC {ECO:0000313|Proteomes:UP000007842}; RA Ou H.-Y., Li P., Zhao C., O'Hagan D., Deng Z.; RT "Complete genome sequence of Streptomyces cattleya strain DSM 46488."; RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|PIRSR:PIRSR001227-2}; CC Note=Binds 1 Ca(2+) ion per dimer. {ECO:0000256|PIRSR:PIRSR001227- CC 2}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP003219; AEW94549.1; -; Genomic_DNA. DR RefSeq; WP_014142944.1; NC_017586.1. DR STRING; 1003195.SCAT_2197; -. DR EnsemblBacteria; AEW94549; AEW94549; SCATT_21780. DR KEGG; sct:SCAT_2197; -. DR KEGG; scy:SCATT_21780; -. DR PATRIC; fig|1003195.11.peg.3711; -. DR eggNOG; ENOG4105CUJ; Bacteria. DR eggNOG; COG2366; LUCA. DR KO; K01434; -. DR OMA; HPYDQDP; -. DR OrthoDB; 186419at2; -. DR BioCyc; SCAT1003195:GJCM-2207-MONOMER; -. DR Proteomes; UP000007842; Chromosome. DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro. DR Gene3D; 1.10.439.10; -; 1. DR Gene3D; 3.60.20.10; -; 3. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR014395; Pen/GL7ACA/AHL_acylase. DR InterPro; IPR023343; Penicillin_amidase_dom1. DR InterPro; IPR002692; S45. DR PANTHER; PTHR34218; PTHR34218; 1. DR Pfam; PF01804; Penicil_amidase; 1. DR PIRSF; PIRSF001227; Pen_acylase; 1. DR SUPFAM; SSF56235; SSF56235; 1. PE 4: Predicted; KW Calcium {ECO:0000256|PIRSR:PIRSR001227-2}; KW Complete proteome {ECO:0000313|Proteomes:UP000007842}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR001227-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000007842}. FT ACT_SITE 299 299 Nucleophile. {ECO:0000256|PIRSR: FT PIRSR001227-1}. FT METAL 210 210 Calcium. {ECO:0000256|PIRSR:PIRSR001227- FT 2}. FT METAL 377 377 Calcium. {ECO:0000256|PIRSR:PIRSR001227- FT 2}. FT METAL 380 380 Calcium. {ECO:0000256|PIRSR:PIRSR001227- FT 2}. SQ SEQUENCE 909 AA; 99746 MW; C2D589FC334DCE4C CRC64; MPANPSGPPA KKKGRRARLV VILVVLLLVA GIGYGSYWSV STVRASFPVT TGTLKLNGLT APVQVKRDDH GIPQIYADDA ADLFRAQGYV QAQDRFWEMD VRRHLTAGRL SEMFGSGQVE NDAFIRTLGW RRVAQQEWDT QLSPTAKAYL RAYSDGVNAY LSGHHGSALS VEYAVLGLTH SYTPERWTPV DSISWLKAMA WDLRSNIKDE IDRALMTSRL TPAQIAQLYP EYPYGRNRPI TGGGSVTPDG SEYVPAGRTA TGGGQTTSQR YPNAQLSALS RTIDQLPALL GPSGNGIGSN SWVVSGTYTT TGKPMLANDP HLAPQMPSLW YQMGLHCRTV NAACPYDVSG YTFSGMPGVV IGHNQDIAWG MTNMGADVTD LYLEKVTADS YLYDGKQVPF RTRQETIKVA GGSSRVITVR ETRDGMPLIS DRSDEMAEVG QNAPVGQTAP DRRDGYAVAL RWTALTPGKT MEAVFELDRA TDFTHFRKAA QDFAVPAQNL VYADTRNNIG YQAPGMIPVR HKVTGGIPDD GRYPVPGWDP DYRWTGYIPA AALPWEYNPK RGYIVTANQA VTDKKYPYLL TDDWGYGTRS QRINDLIASK IAGGGKISMD DMQSMQMDDS SEIAKLLVPY LLKVDISDPY VRQAQQLLEG WDFNQDGDSA AAAYFNAVWR NVLKLAFGNK LPKEVRPKGQ CLRVPPAGGS GPVDDLGTPK LVTECGQRDP AEAQPDGGDR WFEVVRAILP DATNPWWNTS TTGAKNGTDR DQLLAKAMKD ARWELTSKLG KDINTWSWGR LHKMTLRNQT LGTQGPAIVK WLLNRGPWQL GGGEAAVNAT GWNAAAGYDV VWVPSMRMIV SLDDFDKSRW INLTGASGHA YDAHYSDQTA MWVDGQLLPW AYSGGAVDKA AQDKLTLTP //