ID F7W101_SORMK Unreviewed; 862 AA. AC F7W101; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 20-DEC-2017, entry version 45. DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000256|HAMAP-Rule:MF_03002}; DE Short=eIF3c {ECO:0000256|HAMAP-Rule:MF_03002}; DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03002}; DE Short=eIF3 p93 {ECO:0000256|HAMAP-Rule:MF_03002}; DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000256|HAMAP-Rule:MF_03002}; GN Name=NIP1 {ECO:0000256|HAMAP-Rule:MF_03002}; GN ORFNames=SMAC_02110 {ECO:0000313|EMBL:CCC11453.1}; OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / OS K-hell). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; OC Sordaria. OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC11453.1, ECO:0000313|Proteomes:UP000001881}; RN [1] {ECO:0000313|EMBL:CCC11453.1, ECO:0000313|Proteomes:UP000001881} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell RC {ECO:0000313|Proteomes:UP000001881}; RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC11453.1}; RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891; RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K., RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., RA Poeggeler S., Read N., Seiler S., Smith K., Zickler D., Kueck U., RA Freitag M.; RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence RT reads: Sordaria macrospora, a model organism for fungal RT morphogenesis."; RL PLoS Genet. 6:E1000891-E1000891(2010). CC -!- FUNCTION: Component of the eukaryotic translation initiation CC factor 3 (eIF-3) complex, which is involved in protein synthesis CC of a specialized repertoire of mRNAs and, together with other CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi CC to the 40S ribosome. The eIF-3 complex specifically targets and CC initiates translation of a subset of mRNAs involved in cell CC proliferation. {ECO:0000256|HAMAP-Rule:MF_03002}. CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor CC 3 (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03002, CC ECO:0000256|SAAS:SAAS00891357}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03002, CC ECO:0000256|SAAS:SAAS00535949}. CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. CC {ECO:0000256|HAMAP-Rule:MF_03002, ECO:0000256|SAAS:SAAS00535951}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:CCC11453.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CABT02000018; CCC11453.1; -; Genomic_DNA. DR RefSeq; XP_003350398.1; XM_003350350.1. DR STRING; 771870.XP_003350398.1; -. DR EnsemblFungi; CCC11453; CCC11453; SMAC_02110. DR GeneID; 10807950; -. DR KEGG; smp:SMAC_02110; -. DR EuPathDB; FungiDB:SMAC_02110; -. DR eggNOG; KOG1076; Eukaryota. DR eggNOG; ENOG410XRU3; LUCA. DR InParanoid; F7W101; -. DR KO; K03252; -. DR OrthoDB; EOG092C17F5; -. DR Proteomes; UP000001881; Unassembled WGS sequence. DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule. DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule. DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro. DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:UniProtKB-UniRule. DR GO; GO:0006446; P:regulation of translational initiation; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.10.10; -; 1. DR HAMAP; MF_03002; eIF3c; 1. DR InterPro; IPR027516; EIF3C. DR InterPro; IPR008905; EIF3C_N_dom. DR InterPro; IPR000717; PCI_dom. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR Pfam; PF05470; eIF-3c_N; 1. DR Pfam; PF01399; PCI; 1. DR SMART; SM00088; PINT; 1. DR SUPFAM; SSF46785; SSF46785; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001881}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03002, KW ECO:0000256|SAAS:SAAS00535952}; KW Initiation factor {ECO:0000256|HAMAP-Rule:MF_03002, KW ECO:0000256|SAAS:SAAS00535953}; KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03002, KW ECO:0000256|SAAS:SAAS00535957}; KW Reference proteome {ECO:0000313|Proteomes:UP000001881}. FT DOMAIN 707 792 PINT. {ECO:0000259|SMART:SM00088}. FT COILED 16 43 {ECO:0000256|SAM:Coils}. FT COILED 186 206 {ECO:0000256|SAM:Coils}. FT COILED 327 347 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 862 AA; 97511 MW; A28F8DFBFEC82158 CRC64; MSRFFRGGDD SSTDSSSEEE EVYSSEEEEK VKAEDESSSE EESDEEEESE EEEESDSDEE EGPKKKGANR FLQSDDESEE EEEEEQSEDE ATTKVKSAKD KRFDELESTI SQIQNGQKIN DWSLIASEFD KLNRQVVKLQ DGSKAPKSYI KAIADLEDFM NETLAKQKVT PKKMNATNAR GLNAVKQRIR KNNKDYQTQI DAYRKDADAF MESDDEIPAP KTVSKALRFA EAPVVSAEQQ EEDDKGFSTV DSRGKVVQYT PESILKHLRT IIESRGKKNT DRLEQIKVME TLNKVVPITP YQKIRVLQTL ISARFDLGAG GAAQMPLDQW KAAERDLASL LEILEKEKDH VVVEGAEEWD DDDKLPTIPE GEKYLKVPGS VVSLIERLDD ELTRSLQAID PHTSEYIDRL TDEGSLYNTI FRGLLYYEHL RKDASLEVPQ ESLNRIIQRR LDHVYYKPAQ VVKILEENAW KQSGDAGKLI NILSNYLFEN SEGIIRARAM LCQIYFLALH DEYYKSRDLM LTSHLQETIA NFDIATQILY NRTLVQVGLC AFRKGLVYDA QNTLQEICGS GRQKELLAQG VMIQRYSQVT PEQERLEKQR QLPFHMHINL ELLECVYLTC SMLLEIPLLA QTGSSPDVKK RIISKTYRRM LEYHERQIFT GPPENTRDHV MQASKALAAG EWKKATDFIH SIKIWDLMPN TEDIKTMLAK QIQEEGLRTY LFTYAPFYDT LAIATLSSMF ELDSRKVSAV VSKMISHEEL AAALDQVTET VIFRKGVELS RLQSLALTLS DKASSLIETN ERTLEQKTQG SANAFSRKDN RGGGQRGGRG GARGGARTGG NPQRQAGGTQ FTGGALGNAV RG //