ID F7W101_SORMK Unreviewed; 862 AA. AC F7W101; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 11-DEC-2013, entry version 16. DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C; DE Short=eIF3c; DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog; DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog; GN Name=NIP1; ORFNames=SMAC_02110; OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / OS K-hell). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; OC Sordaria. OX NCBI_TaxID=771870; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell; TISSUE=Mycelium; RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891; RA Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., RA Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., RA Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., RA Freitag M.; RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence RT reads: Sordaria macrospora, a model organism for fungal RT morphogenesis."; RL PLoS Genet. 6:E1000891-E1000891(2010). CC -!- FUNCTION: Component of the eukaryotic translation initiation CC factor 3 (eIF-3) complex, which is involved in protein synthesis CC and, together with other initiation factors, stimulates binding of CC mRNA and methionyl-tRNAi to the 40S ribosome (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. CC -!- SIMILARITY: Contains 1 PCI domain. CC -!- SIMILARITY: Contains PCI domain. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CABT02000018; CCC11453.1; -; Genomic_DNA. DR RefSeq; XP_003350398.1; XM_003350350.1. DR GeneID; 10807950; -. DR KEGG; smp:SMAC_02110; -. DR KO; K03252; -. DR OrthoDB; EOG75QRCP; -. DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-HAMAP. DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-HAMAP. DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-HAMAP. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-HAMAP. DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:UniProtKB-HAMAP. DR GO; GO:0006446; P:regulation of translational initiation; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.10.10; -; 1. DR HAMAP; MF_03002; eIF3c; 1; -. DR InterPro; IPR027516; EIF3C. DR InterPro; IPR008905; EIF3C_N_dom. DR InterPro; IPR000717; PCI_dom. DR InterPro; IPR011991; WHTH_DNA-bd_dom. DR Pfam; PF05470; eIF-3c_N; 1. DR Pfam; PF01399; PCI; 1. DR SMART; SM00088; PINT; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis. FT DOMAIN 646 775 PCI (By similarity). SQ SEQUENCE 862 AA; 97511 MW; A28F8DFBFEC82158 CRC64; MSRFFRGGDD SSTDSSSEEE EVYSSEEEEK VKAEDESSSE EESDEEEESE EEEESDSDEE EGPKKKGANR FLQSDDESEE EEEEEQSEDE ATTKVKSAKD KRFDELESTI SQIQNGQKIN DWSLIASEFD KLNRQVVKLQ DGSKAPKSYI KAIADLEDFM NETLAKQKVT PKKMNATNAR GLNAVKQRIR KNNKDYQTQI DAYRKDADAF MESDDEIPAP KTVSKALRFA EAPVVSAEQQ EEDDKGFSTV DSRGKVVQYT PESILKHLRT IIESRGKKNT DRLEQIKVME TLNKVVPITP YQKIRVLQTL ISARFDLGAG GAAQMPLDQW KAAERDLASL LEILEKEKDH VVVEGAEEWD DDDKLPTIPE GEKYLKVPGS VVSLIERLDD ELTRSLQAID PHTSEYIDRL TDEGSLYNTI FRGLLYYEHL RKDASLEVPQ ESLNRIIQRR LDHVYYKPAQ VVKILEENAW KQSGDAGKLI NILSNYLFEN SEGIIRARAM LCQIYFLALH DEYYKSRDLM LTSHLQETIA NFDIATQILY NRTLVQVGLC AFRKGLVYDA QNTLQEICGS GRQKELLAQG VMIQRYSQVT PEQERLEKQR QLPFHMHINL ELLECVYLTC SMLLEIPLLA QTGSSPDVKK RIISKTYRRM LEYHERQIFT GPPENTRDHV MQASKALAAG EWKKATDFIH SIKIWDLMPN TEDIKTMLAK QIQEEGLRTY LFTYAPFYDT LAIATLSSMF ELDSRKVSAV VSKMISHEEL AAALDQVTET VIFRKGVELS RLQSLALTLS DKASSLIETN ERTLEQKTQG SANAFSRKDN RGGGQRGGRG GARGGARTGG NPQRQAGGTQ FTGGALGNAV RG //